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Biodegradable medical human body cavity channel inner bracket and preparation method thereof

An internal stent and human body technology, applied in stents, medical science, surgery, etc., can solve problems such as inability to be degraded and absorbed, corrosion failure, accelerated stents, etc., to avoid endothelial hyperplasia and restenosis, improve corrosion resistance, and good safety Effect

Inactive Publication Date: 2013-02-06
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Technical issues: At present, clinical medical stainless steel and nickel-titanium alloy metal stents cannot be degraded and absorbed in the body, while the absorbable medical magnesium alloy stents reported in common research are mostly made of magnesium alloy tubes processed by laser cutting, which has poor flexibility; magnesium alloy has poor welding performance , which makes it difficult to prepare magnesium alloy medical stents by welding, and the welds and joints with poorer corrosion resistance in the stents can accelerate the corrosion failure in the stent body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] A bioabsorbable medical human cavity intracavity stent, which is composed of a tube network stent integrally woven by a single magnesium alloy filament, a magnesium oxide film bottom layer attached to the surface of the magnesium alloy wire, loaded with the drug paclitaxel and medical X The composition of the degradable polylactic acid polymer surface layer of the ray developer, the diameter of the magnesium alloy wire is φ0.30mm, and the contents of paclitaxel and X-ray developer in the polylactic acid surface layer are 0.05% and 2% by weight respectively . The thickness of the bottom layer of the magnesium oxide film is about 10 μm, and the thickness of the degradable polylactic acid surface layer is controlled between 20-30 μm.

[0056] The preparation steps of the bioabsorbable medical body cavity stent are as follows:

[0057] 1) Firstly, the AZ31B magnesium alloy is drawn and processed into a magnesium alloy wire with a diameter of φ0.30mm;

[0058] 2) Use a sin...

Embodiment 2

[0063] A bioabsorbable stent for medical human body cavity, which is composed of a tubular network stent made of two magnesium alloy filaments cross-woven, a magnesium oxide and hydroxyapatite composite film bottom layer attached to the surface of the magnesium alloy wire, and a load Composed of the degradable polylactic acid polymer surface layer of drug paclitaxel and medical X-ray imaging agent, the diameter of the magnesium alloy wire is φ0.40mm, and the contents of paclitaxel and X-ray imaging agent in the polylactic acid surface layer are calculated by weight percentage respectively 0.1% and 1%. The thickness of the bottom layer of the magnesium oxide film is about 20 μm, and the thickness of the degradable polylactic acid surface layer is controlled between 20-30 μm.

[0064] The preparation steps of the bioabsorbable medical body cavity stent are as follows:

[0065] 1) Firstly, AZ91 magnesium alloy is drawn and processed into a magnesium alloy wire with a diameter of...

Embodiment 3

[0071] A bioabsorbable medical human cavity intracavity stent, which is composed of a tubular network stent made of a single magnesium alloy filament cross-woven, a hydroxyapatite film bottom layer attached to the surface of the magnesium alloy wire, and a drug Rapa Degradable lactic acid and glycolic acid copolymer PLGA macromolecule surface layer composed of mycin and medical X-ray contrast agent, the diameter of the magnesium alloy wire is φ0.30mm, rapamycin and X-ray contrast agent in the polylactic acid surface layer The content is respectively 0.05% and 2% by weight percentage. The thickness of the bottom layer of the hydroxyapatite film is about 10 μm, and the thickness of the degradable PLGA surface layer is controlled between 20-30 μm.

[0072] The preparation steps of the bioabsorbable medical body cavity stent are as follows:

[0073] 1) Firstly, the AZ31B magnesium alloy is drawn and processed into a magnesium alloy wire with a diameter of φ0.30mm;

[0074] 2) Us...

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Abstract

The invention relates to a biodegradable medical human body cavity channel inner bracket and a preparation method thereof. The biodegradable medical human body cavity channel inner bracket is prepared by performing crosswise weaving and surface coating treatment on a single or a plurality of degradable magnesium alloy long wires, and very high flexibility, so that the stimulation and damages of the bracket on the inner walls of the blood vessels and esophagi are lowered to the maximum extent; the bracket can be degraded and absorbed by a human body after operation and healing, so that the problem of endotheliosis restenosis caused by long-time existing of a non-degradable bracket in vivo is solved; due to the adoption of a surface degradable ceramic coating and a high-polymer film dual-protection layer, the corrosion resistance of the magnesium alloy wires can be effectively improved, and the degrading speed of the magnesium alloy wires is controlled; carried medicaments have long-term treating effects through slow release; the problem of difficulty in X-ray development of a light metal magnesium alloy is well solved through a carried developing agent; and the biodegradable medical human body cavity channel inner bracket can be used for expanding and supporting human body inner tube cavity channels such as narrow blood vessels, esophagi, bile ducts, intestinal tracts or urethrae and the like, and belongs to the technical field of manufacturing of medical instruments.

Description

technical field [0001] The present invention relates to a bioabsorbable medical body intracavity stent, in particular to a tubular mesh stent formed by cross-braiding single or multiple magnesium alloy long wires, and a removable support attached to the surface of the magnesium alloy wires. The absorbable medical human cavity intracavity stent composed of the bottom layer of the degradable bioceramic film and the degradable polymer surface layer loaded with specific drugs and medical X-ray contrast agents has excellent flexibility, absorbability, anti-restenosis ability, and degradation With the advantages of controllable speed and strong X-ray imaging ability, it can be used to expand and support narrowed blood vessels, esophagus, bile duct, intestinal tract or urethra, etc., and belongs to the technical field of medical devices. Background technique [0002] Vascular embolism, esophageal cancer, benign prostatic hyperplasia and biliary stones are common luminal obstructive...

Claims

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Application Information

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IPC IPC(8): A61F2/90A61L31/08A61L31/16A61L31/18
CPCA61L31/022A61L31/16A61L31/18A61L31/088A61F2/90A61L31/10A61L31/148C08L67/04
Inventor 储成林薛烽白晶郭超盛晓波董寅生林萍华
Owner SOUTHEAST UNIV
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