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Derivative of composition extracted from animal organs

A technology of mixture and extraction method, applied in the field of derivatives of compositions and their preparation, can solve problems such as rate reduction, and achieve the effects of simple process, short production cycle and low investment

Inactive Publication Date: 2014-05-14
青岛亚博生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Low-molecular-weight heparin sodium degraded by chemical methods is a mixture that contains different fragments with a molecular weight ranging from several hundred to nearly ten thousand. It also needs to be purified and separated by fractional precipitation, which often reduces the yield.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] A method for extracting heparin sodium, characterized in that it comprises the steps of:

[0090] (1) Add quartz sand to the mucous membrane of the small intestine of the pig, and ultrafinely pulverize it;

[0091] (2) Hydrolyze the pulverized material with enzymes, the enzyme preparation used for hydrolysis is: a mixture of cellulase: amylase: lipase in the ratio of (1):(1):(1) in parts by mass;

[0092] (3) Ion exchange fiber adsorption;

[0093] (4) Ion exchange fiber elution;

[0094] (5) Heparin sodium precipitation;

[0095] (6) Purification of heparin sodium;

[0096] (7) Dry to obtain pure heparin sodium.

Embodiment 2

[0098] A method for extracting heparin sodium, characterized in that it comprises the steps of:

[0099] (1) Add quartz sand to mucous membrane of bovine small intestine, and ultrafinely pulverize it;

[0100] (2) Hydrolyze the pulverized material with enzymes, the enzyme preparation used for hydrolysis is: a mixture of cellulase: amylase: lipase in the ratio of (1):(1):(1) in parts by mass;

[0101] (3) Ion exchange fiber adsorption;

[0102] (4) Ion exchange fiber elution;

[0103] (5) Heparin sodium precipitation;

[0104] (6) Purification of heparin sodium;

[0105] (7) Dry to obtain pure heparin sodium.

Embodiment 3

[0107] A method for extracting heparin sodium, comprising the following steps:

[0108] (1) Add 10 parts of quartz sand to 100 parts of porcine small intestinal mucosa, and ultrafinely pulverize it;

[0109] (2) Hydrolyze the pulverized mixture with enzymes. The enzyme preparation used for hydrolysis is: cellulase produced by Trichoderma reesei: alkaline β-amylase: rabbit pancreatic lipase, in the form of (1): (1): (1) A mixture formed by mixing parts by mass ratio;

[0110] Add 100 parts of pulverized mixture into the reaction kettle, raise the temperature to 40°C, keep it warm for 10 minutes, add 50 parts of water, add 1 part of NaCl, add MgCl 2 0.01 part, control the temperature at 30°C, adjust the pH to 8 with lye, add 1 part of enzyme preparation, stir for 1 hour and add a precipitant, the precipitant is selected from 2 parts of polyaluminium chloride, let it stand for 2 hours, and remove the supernatant Filter with a 100-mesh filter cloth to collect the filtrate;

[...

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PUM

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Abstract

The invention relates to a derivative of a composition extracted from animal organs, wherein the animal organs are selected from livers, small intestines, large intestines and lungs, and animals are selected from cows, pigs, sheep and dogs.

Description

technical field [0001] The invention relates to a derivative of the composition extracted from animal organs, especially a derivative of the composition extracted from animal organs and a preparation method thereof. Background technique [0002] Compositions extracted from animal organs have always been an important source of medicine, food, daily necessities, and cosmetics. [0003] Derivatives of compositions extracted from animal organs have always been an important source of medicine, food, daily necessities, and cosmetics. [0004] Mast cells of animal connective tissue can produce acidic mucopolysaccharide substances, one of which is called heparin. Heparin has a strong anticoagulant effect, can anticoagulant, antithrombosis and adjust blood lipids. It is used as the first choice drug for preventing and treating thromboembolic diseases such as deep venous thrombosis. Heparin sodium also has anti-inflammatory, anti-allergy, anti-virus, anti-cancer, etc. A variety of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/10A61K35/42A61K35/407A61K35/38A61P7/02
Inventor 曲辉张春革
Owner 青岛亚博生物科技有限公司
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