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Acetylcysteine gargle for treating dental ulcers, and preparation method thereof

A technology for acetylcysteine ​​and oral ulcers, applied in the field of acetylcysteine ​​gargles, can solve the problems of lack of effective drugs and means for the care and treatment of oral ulcers, and achieve rich varieties, good uniformity, and high quality good controllability

Inactive Publication Date: 2013-04-10
TIANJIN KUNJIAN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, clinicians lack effective drugs and methods for the nursing and treatment of oral ulcers in such patients.

Method used

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  • Acetylcysteine gargle for treating dental ulcers, and preparation method thereof
  • Acetylcysteine gargle for treating dental ulcers, and preparation method thereof
  • Acetylcysteine gargle for treating dental ulcers, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation method of acetylcysteine ​​gargle for treating oral ulcers includes the following steps:

[0027] Cool a small amount of purified water to 10°C, add 15g of acetylcysteine, stir and mix, adjust the pH to 6.0 with sodium hydroxide aqueous solution while stirring, after the acetylcysteine ​​is dissolved, at 10°C, Add 0.5g solution stabilizer, 0.05g flavoring agent and 0.5g preservative and mix; then add 20g poloxamer, stir until the poloxamer is dissolved, let stand for 18h, filter, and add purified water to the filtrate to make 100g, ready Get an acetylcysteine ​​gargle used to treat oral ulcers.

[0028] The solution stabilizer is composed of the chelating agent ethylenediaminetetraacetic acid and the solution buffer sodium citrate with a mass ratio of 1:4.

[0029] The flavoring agent is composed of sweetener sucrose and strawberry flavor with a mass ratio of 1:0.4.

[0030] The preservative is propyl paraben.

Embodiment 2

[0032] The preparation method of acetylcysteine ​​gargle for treating oral ulcers includes the following steps:

[0033] Cool a small amount of purified water to 15°C, add 10g of acetylcysteine, stir and mix. Under stirring, adjust the pH to 6 with potassium hydroxide aqueous solution. After the acetylcysteine ​​is dissolved, at 15°C, Add 0.4g of solution stabilizer, 0.1g of flavoring agent and 1g of preservative and mix; then add 15g of poloxamer, stir until the poloxamer is dissolved, let stand for 16h, filter, and add purified water to the filtrate to make 100g. Acetylcysteine ​​gargle used to treat oral ulcers.

[0034] The solution stabilizer is composed of the chelating agent sodium ethylenediaminetetraacetate and the solution buffering agent sodium citrate with a mass ratio of 1:3.

[0035] The flavoring agent is composed of sucralose and sweet-scented osmanthus essence with a mass ratio of 1:0.3.

[0036] The preservative is propyl paraben.

Embodiment 3

[0038] The preparation method of acetylcysteine ​​gargle for treating oral ulcers includes the following steps:

[0039] Cool a small amount of purified water to 5°C, add 1g of acetylcysteine, stir and mix, adjust the pH value to 5.0 with sodium hydroxide aqueous solution while stirring, after the acetylcysteine ​​is dissolved, at 5°C, Add 0.1g solution stabilizer, 0.01g flavoring agent and 0.1g preservative and mix; then add 5g poloxamer, stir until the poloxamer is dissolved, let stand for 12h, filter, and add purified water to the filtrate to make 100g, ready to make Get an acetylcysteine ​​gargle used to treat oral ulcers.

[0040] The solution stabilizer is composed of the chelating agent ethylenediaminetetraacetic acid and the solution buffer sodium citrate with a mass ratio of 1:2.

[0041] The flavoring agent is composed of sweetener sodium saccharin and peppermint flavor with a mass ratio of 1:0.2. The sweetener sodium saccharin of this embodiment can also be replaced with...

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Abstract

The invention discloses an acetylcysteine gargle for treating dental ulcers, and a preparation method thereof. The preparation method comprises the following steps: cooling a small amount of purified water by mass percent; adding the acetylcysteine and then stirring and mixing; under a stirring action, regulating the pH value until the acetylcysteine is dissolved; adding a solution stabilizer, a corrigent and a corrosion remover and mixing; adding poloxamer and then stirring till dissolving; statically placing an obtained mixture; filtering the mixture; and adding the water to a filtrate, thereby obtaining the acetylcysteine gargle. The acetylcysteine gargle prepared by using the method has the functions of quickly relieving pain and preventing / treating the ulcers, and especially has the medicinal efficacy of inhibiting the continuous ulcer expansion and promoting the ulcer wound healing for patients accepting radiotherapy, chemotherapy and bone marrow transplantation. The method provided by the invention has the advantages of simple preparation process and easiness in industrial scale production realization. The acetylcysteine gargle provided by the invention has the advantages of high stability, single and clear active ingredients and good quality controllability, thereby enriching the drug category for adjuvant therapy of clinical cancer. Therefore, a good selection for the nursing service of the patients accepting the radiotherapy is provided.

Description

technical field [0001] The invention belongs to the technical field of medicines and relates to an acetylcysteine ​​gargle. Background technique [0002] There are about 3.2 million cancer patients in China every year, which has already posed a huge threat to the health of our country. Radiotherapy, chemotherapy, and bone marrow transplantation have become the routine means for patients to fight cancer, and can receive significant therapeutic effects. However, while these methods suppress cancerous cells, they also cause varying degrees of damage to the body's own immune system, accompanied by the occurrence of various infections. As a non-keratinized site, oral mucosal ulcers are the most common complication in patients receiving radiotherapy, especially in patients receiving head radiotherapy, the incidence of oral ulcers is close to 100%. The symptoms of oral ulcers are mainly as follows: mucosal erythema, edema, ulcers, and at the same time the pain is unbearable, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/198A61P1/02
Inventor 毛慧华王超王雅琼朱涛邱东旭宇学峰
Owner TIANJIN KUNJIAN BIOLOGICAL PHARMA
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