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Diagnosis-treatment integrative medicine carrying polymer and preparation method thereof

A drug-loaded polymer, photosensitive drug technology, applied in the field of medicine, can solve problems such as poor compatibility

Active Publication Date: 2013-04-17
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditional carriers used to entrap drugs have poor biocompatibility

Method used

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  • Diagnosis-treatment integrative medicine carrying polymer and preparation method thereof
  • Diagnosis-treatment integrative medicine carrying polymer and preparation method thereof
  • Diagnosis-treatment integrative medicine carrying polymer and preparation method thereof

Examples

Experimental program
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preparation example Construction

[0038] Please refer to figure 2 and image 3 A method for preparing a drug-loaded polymer integrated with diagnosis and treatment in one embodiment, comprising the following steps:

[0039] S10. Preparation of polysaccharide-phenyl p-nitrochloroformate. The concrete steps of preparing polysaccharide-p-nitrochloroformic acid phenyl ester are:

[0040] Dissolve polysaccharide, phenyl p-nitrochloroformate and 4-dimethylaminopyridine in a mixed solution of dimethyl sulfoxide and pyridine, react in an ice bath for 4h~6h, precipitate, centrifuge, and vacuum dry to obtain polysaccharide- Phenyl p-nitrochloroformate.

[0041]The polysaccharide may be at least one of dextran, sodium alginate, hyaluronic acid, heparin, chondroitin sulfate, pectin, pullulan and cyclodextrin. When the polysaccharide is at least one of dextran, sodium alginate, hyaluronic acid, heparin, chondroitin sulfate, pectin, pullulan and cyclodextrin, it has low price, good biocompatibility, and degradation an...

Embodiment 1

[0065] Dissolve 1g of dextran, 0.7g of phenyl p-nitrochloroformate and 0.05g of 4-dimethylaminopyridine in 40mL of a mixed solution of dimethyl sulfoxide and pyridine with a volume ratio of 1:1, and react in an ice bath After 4 hours, it was dropped into 400 mL of a mixture of ethanol and ether, wherein the volume ratio of ethanol and ether was 1:1 to form a precipitate, which was collected by centrifugation and dried in vacuo to obtain dextran-phenyl p-nitrochloroformate.

[0066] 0.5 g of dextran-p-nitrochloroformate and 2 g of cystamine dihydrochloride were dissolved in 50 mL of dimethyl sulfoxide, and reacted at room temperature for 12 h. In ultrapure aqueous solution, using a dialysis membrane with a molecular weight cut-off of 3500, dialyzed for 24 hours, and freeze-dried to obtain dextran-SS-NH 2 .

[0067] Dissolve 0.4g Ce6, 0.2g NHS and 0.4g EDC in 20mL DMSO, react for 1h, then add 2g dextran-SS-NH 2 , Reaction 12h. In ultrapure aqueous solution, using a dialysis m...

Embodiment 2

[0072] Dissolve 1 g of pullulan, 0.7 g of phenyl p-nitrochloroformate, and 0.05 g of 4-dimethylaminopyridine in 40 mL of a mixed solution of dimethyl sulfoxide and pyridine at a volume ratio of 1:1, and place in an ice bath After reacting for 6 hours, drop into the mixed solution of 400mL ethanol and diethyl ether, wherein, the volume ratio of ethanol and diethyl ether is 1:1, a precipitate is formed, the precipitate is collected by centrifugation, and vacuum-dried to obtain pullulan-p-nitrochloroformic acid benzene ester.

[0073] Dissolve 0.5g of pullulan-phenyl p-nitrochloroformate and 1.5g of cystamine dihydrochloride in 50mL of dimethyl sulfoxide, and react at room temperature for 20h. In ultrapure aqueous solution, using a dialysis membrane with a molecular weight cut-off of 3500, dialyzed for 72 hours, and freeze-dried to obtain Pullulan-SS-NH 2 .

[0074] Dissolve 0.5g PPIX, 0.5g NHS and 1g EDC in 20mL DMSO, react for 4h, then add 10g Pullulan-SS-NH 2 , Reaction 20h...

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Abstract

The invention discloses a diagnosis-treatment integrative medicine carrying polymer, which comprises polysaccharide and a photosensitive drug containing carboxyl, wherein the polysaccharide is connected with the photosensitive drug containing carboxyl through a disulfide bond. As the polysaccharide can be changed into glucose under the action of enzyme to be absorbed by animal bodies and further is degraded into carbon dioxide and water, the polysaccharide has a good biodegradability in the animal bodies, and degradation products are nontoxic. Compared with the traditional carrier for carrying medicine, the diagnosis-treatment integrative medicine carrying polymer has a better biocompatibility. The invention also discloses a preparation method of the medicine carrying polymer.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a drug-loaded polymer integrated with diagnosis and treatment and a preparation method thereof. Background technique [0002] Cancer seriously endangers human life and health, and has been listed as the "second killer" facing human beings after cardiovascular disease. Therefore, accurate diagnosis and effective treatment of cancer have become an urgent need. Fluorescence imaging is an important tool for tumor detection. Fluorescent molecules such as chlorin e6 (Chlorin e6, Ce6), protoporphyrin IX (PPIX), pheophorbide-a (pheophorbide-a, pheo-A) and other fluorescent molecules are widely used because of their near-infrared excitation properties. Applied to the research of fluorescence imaging, while it can be used for fluorescence imaging, it can also be excited by near-infrared irradiation to generate singlet oxygen, thereby killing cancer cells. [0003] Nanotechnology is an emerging a...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K47/48A61K41/00A61P35/00A61K47/61
Inventor 蔡林涛刘朋岳彩霞石碧华王碧易虎强刘斌魏伟
Owner SHENZHEN INST OF ADVANCED TECH
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