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Method for preparing silver-containing calcium phosphate

A technology of silver calcium phosphate and serum, applied in chemical instruments and methods, phosphorus compounds, nanotechnology for materials and surface science, etc., can solve the problem of poor stability of antibacterial ions, difficulty in industrialized continuous production, and low loading ratio and other issues, to achieve the effect of easy industrial stable mass production, stable industrial mass production, and reduction of energy consumption costs

Inactive Publication Date: 2014-11-26
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent 02129370.8 discloses a silver-loaded fluoroapatite antibacterial agent and its preparation method. In this method, amorphous nano-silver-loaded fluoroapatite powder is first prepared by co-precipitation method, and then the silver-loaded effect is enhanced by high-temperature calcination. This method adopts a batch process, which is not easy for industrial continuous production
The disadvantage is that the formed silver-ammonia complex reduces the loading rate of silver ions. In addition, the calcium-phosphorus ratio is 1.67, and there are not enough calcium vacancies, which will also reduce the loading of silver.
The stability of the antibacterial ions in the structure of this type of antibacterial agent is poor, the loading ratio is low, the color is unstable, and the light is easy to change color, and the early release of antibacterial agent ions is large, and the long-term release effect cannot actually be achieved.

Method used

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  • Method for preparing silver-containing calcium phosphate
  • Method for preparing silver-containing calcium phosphate
  • Method for preparing silver-containing calcium phosphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] 1. Preparation of phase A raw material solution, containing 0.09M calcium nitrate, 0.002M silver nitrate and 0.3M polyethylene glycol (PEG-20000) solution;

[0066] 2. Preparation of phase B raw material solution, containing 0.06M phosphoric acid and 0.18M sodium hydroxide solution;

[0067] 3. Set the flow rate F of the phase A raw material liquid delivery pump A =100mL / min, the flow rate F of the phase B raw material liquid delivery pump B =100mL / min, at room temperature of 25°C, the two-phase raw material liquid is simultaneously transported to a microchannel continuous mixing reactor with a channel size of 105 μm. After the two-phase materials are uniformly differentially mixed, the continuous integral reaction forms silver-containing calcium phosphate Aggregates;

[0068] 4. Transport the mixed reaction product calcium phosphate aggregate sol to a washing and dehydrating device, wash with water three times, and vacuum dry at 60° C. to constant weight to obtain am...

Embodiment 2

[0072] 1. Preparation of phase A raw material solution, containing 0.09M calcium nitrate, 0.005M silver nitrate and 0.3M polyethylene glycol (PEG-1500) solution;

[0073] 2. Preparation of phase B raw material solution, containing 0.06M phosphoric acid and 0.18M sodium hydroxide solution;

[0074] 3. Set the flow rate F of the phase A raw material liquid delivery pump A =1000mL / min, the flow rate F of the phase B raw material liquid delivery pump B =1000mL / min, at 50°C, the two-phase raw material liquid is simultaneously transported to a microchannel continuous mixing reactor with a channel size of 105 μm. After the two-phase materials are uniformly mixed differentially, the continuous integral reaction forms silver-containing calcium phosphate aggregates body;

[0075] 4. Transport the mixed reaction product calcium phosphate aggregate sol to a washing and dehydrating device, wash with water three times, and vacuum dry at 60° C. to constant weight to obtain amorphous silver...

Embodiment 3

[0077] 1. Preparation of phase A raw material solution, containing 0.225M calcium nitrate, 0.0056M silver nitrate and 2.25M polyethylene glycol (PEG-20000) solution;

[0078] 2. Preparation of phase B raw material solution, containing 0.15M phosphoric acid and 0.45M sodium hydroxide solution;

[0079] 3. Set the flow rate F of the phase A raw material liquid delivery pump A =10mL / min, the flow rate F of the phase B raw material liquid delivery pump B =10mL / min, at room temperature of 30°C, the two-phase raw material liquid is simultaneously transported to a microchannel continuous mixing reactor with a channel size of 10 μm. After the two-phase materials are uniformly differentially mixed, the continuous integral reaction forms silver-containing calcium phosphate Aggregates;

[0080] 4. Transport the mixed reaction product calcium phosphate aggregate sol to a washing and dehydrating device, wash with water three times, and vacuum dry at 60° C. to constant weight to obtain am...

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Abstract

The invention discloses a method for preparing silver-containing calcium phosphate and relates to silver-containing calcium phosphate. The method for preparing silver-containing calcium phosphate, disclosed by the invention, is based on a differential reaction technology and has the advantages that the continuous and stable production can be achieved, the process preparation and raw materials are simple, the reaction conditions are mild and controllable, the production cycle is short, and the whiteness is stable. The method comprises the following steps of: (1) preparing raw material liquid; (2) conveying A-phase clear liquid and B-phase clear liquid, which are obtained in the step (1), to a micro-channel continuous mixing system through a pipeline by a metering pump of a raw material conveying system, and carrying out continuous integration reaction so as to form silver-containing calcium phosphate aggregate; (3) conveying a mixing reaction product, namely silver-containing calcium phosphate aggregate sol, to a dehydration and washing device, and drying the washed product so as to obtain amorphous silver-containing calcium phosphate powder; and (4) carrying out high temperature treatment on the amorphous silver-containing calcium phosphate powder obtained in the step (3), thereby obtaining silver-containing calcium phosphate microcrystalline powder with stable whiteness.

Description

technical field [0001] The invention relates to silver-containing calcium phosphate, in particular to a method for preparing silver-containing calcium phosphate by utilizing a transition state complex. Background technique [0002] In recent years, with the gradual improvement of people's living standards, because people have put forward higher requirements for living comfort and hygiene, silver-based inorganic antibacterial agents have been extensively studied, and have been widely used in textiles, building materials, environmental protection and other fields. widely used. Since most of the antibacterial functional facilities will have frequent contact with the human body, the antibacterial materials used for them should not only require good antibacterial performance, but also have excellent non-toxicity and biocompatibility. Calcium phosphate is a kind of material with excellent biocompatibility. The current research shows that combining silver and calcium phosphate, as...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32B82Y30/00
Inventor 谢容泉林亚庆关涛关栋云
Owner 关涛
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