Preparation method of biomimetic mussel adhesive based on synthesis of oxetane derivatives

A technology for oxetane and derivatives is applied in the field of preparation of biomimetic mussel glue, can solve the problems of biomimetic mussel glue biocompatibility, high adhesion strength and difficult to achieve unification, etc., and achieves a simple and efficient synthesis method and biological High compatibility and the effect of breaking through technical bottlenecks
CN103289074AInactive Publication Date: 2013-09-11QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
Publication Date
2013-09-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method of a biomimetic mussel adhesive based on the synthesis of oxetane derivatives. The preparation method comprises the following main steps: preparing a phenolic hydroxy protected polymer with a catechol side-chain structure through ring-opening copolymerization of two oxetane derivative monomers; carrying out deprotection on the polymer so as to obtain a catechol structure containing polymer; and after the catechol structure containing polymer is dissolved, adding a certain amount of a crosslinking agent into the polymer, and uniformly mixing so as to obtain the biomimetic mussel adhesive. The method has the characteristics that: 1) the synthesis method is simple and efficient, and raw materials and reagents used in the process of reaction are cheap and easily available, thereby facilitating the amplification of an operating process and industrial production; and 2) the bonding strength is over 5 MPa, so that an effect that a synthetic polymer simulates the attachment protein properties of natural mussels is successfully achieved, and a purpose of integrating certain biocompatibility and high adhesion strength is reached; therefore, the method provides is a novel synthesis technique of biomimetic mussel adhesives and provides a new way for developing novel bionic polymer materials based on the effective protein components of shellfish.
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Description

[0001] technical field

[0002] The invention relates to a method for preparing bionic mussel glue, in particular to a method for preparing bionic mussel glue with higher strength and better biocompatibility by using oxetane derivatives.

[0003] Background technique

[0004] Mussels have a strong adhesive ability, and the adhesive proteins secreted by them can adhere to almost all substrate materials, even including polytetrafluoroethylene, and this natural adhesion does not exist in the underwater or wet environment of synthetic adhesives. Defects with poor performance, and will not cause human immune response, so it has a wide range of applications in waterproof sealants and adhesives in the field of national defense and marine engineering, and medical adhesives for bonding soft and hard tissues in the field of biomedicine. The application prospect has attracted much attention.

[0005] The study found that there is a large amount of 3, 4-dihydroxyphenylalanine (DOPA) i...

Claims

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