Synthetic method of neohesperidin dihydrochlcone

A technology of neohesperidin dihydrochalcone and hesperidin dihydrochalcone, which is applied in the field of synthesis of neohesperidin dihydrochalcone, can solve the problems of large amount of solvent, potential safety hazard, and low content, and achieve The effect of no catalyst, mild conditions and abundant water resources

Active Publication Date: 2013-10-02
LIUZHOU GAOTONG FOOD CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In the above-mentioned first method, since the content of neohesperidin dihydrochalcone in citrus plants is very low, direct extraction is difficult to meet the current requirements, and the amount of solvent lost by direct extraction is very large
In the above-mentioned second method, the usual hydrogenation and reduction operations are carried out under high temperature and high pressure, and there are certain

Method used

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Examples

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Example Embodiment

[0028] Example 1

[0029] A kind of embodiment of the synthetic method of neohesperidin dihydrochalcone of the present invention, the process roadmap of described method is as attached figure 2 As shown, the method includes the following steps:

[0030] (1) Crush the fresh non-mildewed pomelo peel or immature pomelo fruit, then soak the crushed pomelo peel or immature pomelo fruit in ethanol with a purity of 80%, soak at a constant temperature of 40°C for 24 hours, and filter to separate The pomelo peel residue was used to obtain the naringin extract, the filtrate was collected, and the solvent was distilled off under reduced pressure with a rotary evaporator to obtain an extract;

[0031] (2) Separating and purifying the extract obtained in step (1) by column chromatography to obtain naringin; during column chromatography, polyamide is used as filler, and distilled water and 95% ethanol are used as eluent;

[0032] (3) Dissolving sodium hydroxide or potassium hydroxide in ...

Example Embodiment

[0038] Example 2

[0039] A kind of embodiment of the synthetic method of neohesperidin dihydrochalcone of the present invention, described method comprises the following steps:

[0040] (1) Crush the fresh non-mildewed pomelo peel or immature pomelo fruit, then soak the crushed pomelo peel or immature pomelo fruit in ethanol with a purity of 80%, soak at a constant temperature of 40°C for 24 hours, and filter to separate The pomelo peel residue was used to obtain the naringin extract, the filtrate was collected, and the solvent was distilled off under reduced pressure with a rotary evaporator to obtain an extract;

[0041] (2) Separating and purifying the extract obtained in step (1) by column chromatography to obtain naringin; during column chromatography, polyamide is used as filler, and distilled water and 95% ethanol are used as eluent;

[0042] (3) Dissolving sodium hydroxide or potassium hydroxide in water to prepare an alkaline solution with a concentration of 5% by m...

Example Embodiment

[0049] Example 3

[0050] A kind of embodiment of the synthetic method of neohesperidin dihydrochalcone of the present invention, described method comprises the following steps:

[0051] (1) Crush the fresh non-mildewed pomelo peel or immature pomelo fruit, then soak the crushed pomelo peel or immature pomelo fruit in ethanol with a purity of 80%, soak at a constant temperature of 40°C for 24 hours, and filter to separate The pomelo peel residue was used to obtain the naringin extract, the filtrate was collected, and the solvent was distilled off under reduced pressure with a rotary evaporator to obtain an extract;

[0052] (2) Separating and purifying the extract obtained in step (1) by column chromatography to obtain naringin; during column chromatography, polyamide is used as filler, and distilled water and 95% ethanol are used as eluent;

[0053] (3) Dissolving sodium hydroxide or potassium hydroxide in water to prepare an alkaline solution with a concentration of 5% by m...

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Abstract

The invention discloses a synthetic method of neohesperidin dihydrochlcone. The synthetic method comprises the following steps of: adding electrolyte into an anode chamber and a cathode chamber while adding the neohesperidin dihydrochlcone to the cathode chamber, adding the solution into an isolated electrolytic cell to be electrolyzed, concentrating and spin-drying electrolyzed cathode solution, dissolving a product obtained by spin-drying and adjusting the product to acidity, cooling to 0 DEG C, standing to separate out solid, filtering and recrystallizing the solid to obtain the neohesperidin dihydrochlcone. According to the invention, a catalyst and gas hydrogen are not used in the method, reactive hydrogen is provided through electrolysis of water, the newly generated hydrogen has larger activity, and can be subjected to addition reaction with carbon-carbon double bond in the absence of the catalyst, water resources can be abundant, the hydrogen and the oxygen are generated by electrolysis, the hydrogen is taken as a proton source to carry out addition reaction with the neohesperidin dihydrochlcone, and the oxygen cannot cause environmental pollution after the oxygen is directly discharged to atmosphere.

Description

technical field [0001] The invention relates to a method for synthesizing neohesperidin dihydrochalcone, in particular to a method for synthesizing neohesperidin dihydrochalcone by electrolytic hydrogenation. Background technique [0002] Neohesperidin Dihydrochalcone (Neohesperidin Dihydrochalcone, referred to as NHDC) is a flavonoid derivative extracted from natural oranges, tangerines and other plants and hydrogenated. It is characterized by high sweetness, which is about 1500-1800 times that of sucrose, and has a refreshing taste, long-lasting aftertaste, and no unpleasant feeling of saccharin or stevia after use. What is even more commendable is that neohesperidin dihydrochalcone has an excellent taste-improving effect, coupled with the characteristics of its sweetness time is later and longer duration, therefore, neohesperidin dihydrochalcone As a unique additive, ketone is used in combination with other sweeteners to improve the taste of food and beverages, improve t...

Claims

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Application Information

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IPC IPC(8): C25B3/04C07H17/07C07H1/08C25B3/25
CPCC25B9/19C25B1/04C25B3/07C25B15/083C07H1/08C07H15/203C07H1/00
Inventor 谭恒李荫展韦盛孙叶丽赵海南覃仲尧朱泳宏陶丹萍李源志
Owner LIUZHOU GAOTONG FOOD CHEM
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