Compound acetaminophen injection and preparation method thereof

A technology for acetaminophen and injection, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. , the effect of improving stability

Active Publication Date: 2013-12-25
JIANGXI NEW CENTURY MINXING ANIMAL HEALTH PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although pharmaceutical excipients are auxiliary substances in pharmaceutical preparations, if the research on the compatibility of ex

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0031] Example 1:

[0032] The compound paracetamol injection is mainly made of the following raw materials in the following weight ratio: 29 parts of paracetamol, 11 parts of flunixin and meglumine, 20 parts of scutellaria, 14 parts of chrysanthemum, 13 parts of Bupleurum, 0.4 parts of Tween 80, 1.9 parts of benzyl alcohol, 2.2 parts of polysorbate 80, 25 parts of polyethylene glycol 200, 21 parts of polyethylene glycol 400, 23 parts of absolute ethanol, 9 parts of propylene glycol, 17 parts of poloxamer 188, 0.02 parts of calcium sodium edetate, 0.05 parts of sodium sulfite, 0.03 parts of sodium bisulfite, 1100 parts of water for injection;

[0033] The specific preparation method of compound acetaminophen injection is as follows:

[0034] Pretreatment of Scutellaria baicalensis Georgi: pulverize it to 100 meshes, add water 11 times the mass of Scutellaria baicalensis Georgi, and extract with 750w microwave for 20 min. Filter to obtain the first filtrate and the first filter resid...

Example Embodiment

[0040] Example 2

[0041] The compound paracetamol injection is mainly made of the following raw materials in the following weight ratio: 24 parts of paracetamol, 8 parts of flunixin meglumine, 14 parts of scutellaria, 10 parts of chrysanthemum, 8 parts of Bupleurum, 0.3 parts Tween 80, 1.5 parts benzyl alcohol, 2.1 parts polysorbate 80, 22 parts polyethylene glycol 200, 16 parts polyethylene glycol 400, 20 parts absolute ethanol, 7 parts propylene glycol, 15 parts poloxamer 188, 0.01 parts of calcium sodium edetate, 0.04 parts of sodium sulfite, 0.02 parts of sodium bisulfite, 800 parts of water for injection;

[0042] The specific preparation method of compound acetaminophen injection is as follows:

[0043] Scutellaria pretreatment: Take the scutellaria baicalensis and crush it to 100 meshes, add 8 times the weight of scutellaria baicalensis, and extract with a 600w microwave for 10 minutes, filter to obtain the first filtrate and the first filter residue, and add the first filte...

Example Embodiment

[0049] Example 3

[0050] The compound paracetamol injection is mainly made of the following raw materials in the following weight ratio: 32 parts of paracetamol, 13 parts of flunixin meglumine, 22 parts of scutellaria, 16 parts of chrysanthemum, 15 parts of Bupleurum, 0.6 parts Tween 80, 2.2 parts benzyl alcohol, 2.5 parts polysorbate 80, 28 parts polyethylene glycol 200, 24 parts polyethylene glycol 400, 27 parts absolute ethanol, 11 parts propylene glycol, 21 parts poloxamer 188, 0.04 parts of calcium sodium edetate, 0.06 parts of sodium sulfite, 0.04 parts of sodium bisulfite, 1200 parts of water for injection;

[0051] The specific preparation method of compound acetaminophen injection is as follows:

[0052] Pretreatment of Scutellaria baicalensis Georgi: pulverize it to 100 meshes, add water of 12 times the mass of Scutellaria baicalensis Georgi, and extract with 800w microwave for 30 min. Filter to obtain the first filtrate and the first filter residue. Add the first filter ...

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PUM

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Abstract

The invention discloses a veterinary compound acetaminophen injection and a preparation method thereof. The injection mainly comprises raw and auxiliary materials such as acetaminophen, flunixin meglumine, radix scutellariae, chrysanthemum, radix bupleuri, tween 80, benzyl alcohol, polysorbate 80 and polyethylene glycol 200. According to the injection, traditional Chinese medicine is combined with western medicine; the advantages of the traditional Chinese medicine and the western medicine are fused; and the disadvantages of the traditional Chinese medicine and the western medicine are remedied mutually, so that the product is long in action time and has significant anti-inflammation and demulcent effects in comparison with the traditional product. In addition, the invention provides scientific and strict processing steps, and with the adoption of organic compatibility of the raw and auxiliary materials, the solubility of the raw materials and the product stability are improved.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a compound paracetamol injection. Background technique [0002] Acetaminophen (paracetamol) is one of the commonly used antipyretic and analgesic drugs. It is a white crystalline powder, soluble in ethanol, acetone and hot water, insoluble in water, insoluble in petroleum ether and benzene. Clinically, it is often used to treat fever, and can also be used to relieve mild and moderate pain, such as: headache, joint pain, muscle pain, neuralgia, dysmenorrhea, cancer pain, and postoperative pain relief. It is the most commonly used non-anti-inflammatory antipyretic and analgesic drug. Its antipyretic effect is similar to that of aspirin, and its analgesic effect is weak. It has no anti-inflammatory and anti-rheumatic effects. -4 hours. Acetaminophen injection is a sterile aqueous solution of acetaminophen. However, the solubility of paracetamol in water is low, about 1:70, whic...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/08A61K47/34A61P29/00A61K31/167A61K31/44A61K47/10A61K47/26
Inventor 方学锋蔡美萍晏永新舒文林江润蓓张坤屈晓晟
Owner JIANGXI NEW CENTURY MINXING ANIMAL HEALTH PROD CO LTD
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