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Compound antibacterial dry suspension for livestock and poultry and preparation method thereof

An antibacterial dry and suspension technology, applied in the directions of antibacterial drugs, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of inconvenient clinical administration, complex preparation process, poor compliance, etc., and achieve drug availability. High, simple process, improved utilization effect

Active Publication Date: 2014-01-22
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The combined use of the two drugs currently reported is usually in the form of an injection, and the preparation process is relatively complicated, especially in the pH control of sulfa drugs, which is difficult to grasp. If it is administered orally, the compliance is poor and it is not convenient for clinical administration.

Method used

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  • Compound antibacterial dry suspension for livestock and poultry and preparation method thereof
  • Compound antibacterial dry suspension for livestock and poultry and preparation method thereof
  • Compound antibacterial dry suspension for livestock and poultry and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of embodiment 1 dry suspension of the present invention

[0017] Raw material prescription:

[0018]

[0019] Process:

[0020] (1) Weigh the sucrose, crush it, pass through an 80-mesh sieve, and set aside.

[0021] (2) Weigh the prescribed amount of sulfamethoxine, enrofloxacin, sucrose powder, sodium carboxymethylcellulose (CMC-NA), xanthan gum, and sodium citrate, dry them separately and mix them evenly. Mesh sieve, spare.

[0022] (3) Take the mixed powder prepared in (2), make a soft material with 60% ethanol and granulate it with an 18-mesh sieve, dry it in an oven at 60°C, add the prescribed amount of milk essence, and pack 100g after whole grain , that is.

Embodiment 2

[0023] The screening test of embodiment 2 drug prescription of the present invention

[0024] Table 1 Dry Suspension Prescription Screening Form

[0025]

[0026] Table 2 Prescription Screening Results

[0027]

[0028] As can be seen from the above Table 1 and Table 2, the present invention finally obtains a qualified dry suspension with good dispersibility, high sedimentation volume ratio and good mouthfeel through the examination of the consumption of raw and auxiliary materials, wherein the comprehensive evaluation of prescriptions 4 to 5 is qualified, and Prescription 5 is the best. The final selected prescription 5 is the final prescription.

Embodiment 3

[0029] Embodiment 3 dry suspension stability detection test of the present invention

[0030] Three batches of dry suspension were prepared according to the optimal prescription and placed under the conditions of 40°C and 75% humidity for 6 months, and their content, sedimentation volume ratio, redispersibility, moisture content and other indicators were measured. The final results are shown in Table 3.

[0031] Table 3 The compound dry suspension was placed for 6 months at 40°C and 75% humidity

[0032]

[0033] The results showed that the content of the compound dry suspension particles did not change significantly, and all the detection indexes met the regulations, and the stability was good.

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Abstract

The invention provides a compound antibacterial dry suspension for livestock and poultry. The dry suspension is prepared from the following raw materials and auxiliaries in parts by weight: 8-12 parts of sulfamonomethoxine, 3-7 parts of enrofloxacin, 15-25 parts of a suspending agent, 3-9 parts of a deflocculant and 40-78 parts of a flavoring agent. Furthermore, the invention provides a preparation method of the dry suspension. The compound dry suspension is relatively high in oral blood concentration, and in comparison with a preparation in a normal dosage form, the dry suspension is high in effective blood concentration peak and long in effective blood concentration duration; the dry suspension is convenient to use, simple in quality control and favorable for administration; the continuous administration frequency is lowered, and the dry suspension is specifically suitable for veterinary clinical field.

Description

technical field [0001] The invention relates to a compound antibacterial dry suspension for livestock and poultry. Background technique [0002] Sulfamethoxine is a long-acting sulfa drug. For non-enzyme-producing Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella and other Enterobacteriaceae bacteria, Neisseria gonorrhoeae, meningitis Neisseria and Haemophilus influenzae have antibacterial effects. It is clinically used for bacillary dysentery, enteritis, tonsillitis, pneumonia, urinary tract infection and skin suppurative infection. After oral administration, it is well absorbed through the gastrointestinal tract, and reaches the peak plasma concentration after 4 hours, and lasts for a long time. Enrofloxacin is a broad-spectrum bactericidal drug with special effects on mycoplasma. It has bactericidal effect on Escherichia coli, Klebsiella, Salmonella, Proteus, Pseudomonas aeruginosa, Haemophilus,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K9/14A61P31/04A61K31/496
Inventor 徐莎房春林丁晓刚杨海涵吴学渊李超
Owner CHENGDU QIANKUN VETERINARY PHARMA
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