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Method for preparing animal keratin base macromolecular hydrogel and application of hydrogel serving as medicine carrier

A technology based on polymers and animal horns, applied in the field of polymers, can solve the problems of few application results of keratin polymer materials, and achieve good swelling and deswelling properties

Inactive Publication Date: 2014-01-22
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application results of keratin polymer materials in the biomedical field are very few

Method used

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  • Method for preparing animal keratin base macromolecular hydrogel and application of hydrogel serving as medicine carrier
  • Method for preparing animal keratin base macromolecular hydrogel and application of hydrogel serving as medicine carrier
  • Method for preparing animal keratin base macromolecular hydrogel and application of hydrogel serving as medicine carrier

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Weigh 0.25 g of feather keratin powder, put it in a 100 mL three-necked bottle, add 25 mL of 8mol / L urea solution, stir and disperse at 45°C for 1 hour; blow nitrogen, add 0.005 g of dithiothreitol, and stir for 1 hour Finally, add 0.05g of ammonium persulfate and react for 40 minutes; add dropwise 2mL of methacrylic acid (neutralization degree 50%) neutralized with sodium hydroxide, and then add 0.25g of N,N'-methylenebisacrylamide React for 10 minutes, add 0.25g of sodium bicarbonate and stir evenly. After the bubbles in the mixed solution disappear, pour it into a 10mL glass vial and place it in a 60°C water bath to continue the reaction for 2 hours to form a hydrogel; Soak in ethanol for 24 hours (change the ethanol every 2 hours), and then soak in water for 24 hours (change the water every 2 hours), to get the feather keratin-based polymer hydrogel. The swelling rates of the hydrogel in physiological saline and aqueous glucose solution are 50 and 190 (g / g), respect...

Embodiment 2

[0044] Weigh 0.25 g of feather keratin powder into a 100 mL three-necked bottle, add 25 mL of 8mol / L urea solution, stir and disperse at 55°C for 1 hour; blow nitrogen, add 0.005 g of dithiothreitol, and stir for 1 hour, Add 0.05g of potassium persulfate and react for 40 minutes; add dropwise 2mL of methacrylic acid (neutralization degree 50%) neutralized with sodium hydroxide, and then add 0.25g of N,N'-methylenebisacrylamide to react After 10 minutes, add 0.25g of sodium bicarbonate and stir evenly. After the bubbles in the mixed solution disappear, pour it into a 10mL glass vial, place it in a water bath at 55°C and continue to react for 2 hours to form a hydrogel. Finally, dissolve the hydrogel in ethanol Soak in water for 24 hours (change the ethanol every 2 hours), and then soak in water for 24 hours (change the water every 2 hours), to get the feather keratin-based polymer hydrogel. The swelling rates of the hydrogel in physiological saline and aqueous glucose solution ...

Embodiment 3

[0046] Weigh 0.25 g of feather keratin powder into a 100 mL three-necked bottle, add 25 mL of 8mol / L urea solution, stir and disperse at 65°C for 1 hour; blow nitrogen, add 0.005 g of dithiothreitol, and stir for 1 hour, Add 0.05g of potassium persulfate and react for 40 minutes; add dropwise 2mL of methacrylic acid neutralized with sodium hydroxide (neutralization degree: 50%), and add 0.25g of N,N'-methylenebispropylene after the dropwise addition Amide reaction for 10 minutes, add 0.5g sodium bicarbonate, after the mixed solution is stirred evenly and the bubbles disappear, pour it into a 10ml glass vial, put it in a 70°C water bath and continue to react for 2 hours to form a hydrogel; finally put the hydrogel in Soak in ethanol for 24 hours (change the ethanol every 2 hours), and then soak in water for 24 hours (change the water every 2 hours), to get the feather keratin-based polymer hydrogel. The swelling rates of the hydrogel in physiological saline and aqueous glucose ...

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Abstract

The invention provides a method for preparing animal keratin base macromolecular hydrogel and an application of hydrogel serving as medicine carrier. The method comprises the steps as follows: animal keratin is dispersed in urea or a sodium hydroxide solution and then reduced by using dithiothreitol or mercaptoethanol as a reducing agent; and then N,N'-methylene bisacrylamide is used as a cross-linking agent, and polymerization of animal keratin and methacrylic acid is performed, so that the hydrogel is obtained. Experiments show that the prepared animal keratin base macromolecular hydrogel has good swelling and swelling-prevention performance as well as pH sensibility, and has a very good slow-release effect on micro-molecular model medicines, so that the hydrogel can be used as a medicine carrier and is applied to production of pharmaceutic preparations.

Description

technical field [0001] The invention belongs to the technical field of macromolecules, and relates to a preparation method of a macromolecular hydrogel, in particular to a preparation method of an animal keratin-based macromolecular hydrogel. The invention also relates to the application of the animal keratin-based polymer hydrogel as a drug carrier. Background technique [0002] Keratin is a kind of protein, which is very abundant in nature, with an annual output of hundreds of thousands of tons in my country. It is widely found in the epidermis, hair, hoof, shell, claws and feet of humans and animals. It is a renewable resource. But it is usually discarded as waste. Keratin is a structural protein of ectoderm cells, widely present in animal skin and skin derivatives, such as hair, hooves, shells, claws, horns, scales, etc. Keratin can be divided into α - keratin and β - Two types of keratin. The composition of keratin is characterized by high content of cystine and pol...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08F289/00C08F220/06C08F222/38C08H1/06A61K47/42
Inventor 王荣民郭菊花李涛殷晓春何玉凤
Owner NORTHWEST NORMAL UNIVERSITY
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