Preparation method of targeted ferroferric oxide-porphyrin containing composite nanoparticles
A technology of composite nanoparticles and ferric oxide, which is applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problem of weak fluorescence signal intensity of photosensitizers and tumor tissue selection. The problem of low sexual uptake and high cumulative effect of photosensitizers can achieve the effect of inhibiting tumor metastasis, improving immunity and reducing diffusion
Inactive Publication Date: 2014-02-05
HARBIN INST OF TECH
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Abstract
The invention discloses a preparation method of targeted ferroferric oxide-porphyrin containing composite nanoparticles, and relates to a preparation method of composite nanoparticles. The preparation method disclosed by the invention aims at solving the problems that a photosensitizer is high in accumulation effect within normal tissues and even performs a photochemical reaction under a dark light because a photosensitizer fluorescence signal is low in intensity and low in selective uptake for tumour tissues, existing in photodynamic diagnosis and therapy. The method comprises the following steps: 1, preparing magnetic ferroferric oxide nanoparticles coated by silicon dioxide; 2, preparing a porphyrin compound; 3, preparing a porphyrin compound bound by a silane reagent; 4, preparing a porphyrin-folic acid compound; and 5, preparing the targeted ferroferric oxide-porphyrin containing composite nanoparticles. The preparation method based on the magnetic ferroferric oxide-porphyrin composite nanoparticles and disclosed by the invention integrates magnetofluid thermal therapy, magnetic targeting and photodynamic therapy as a therapy means for tumours. The preparation method disclosed by the invention is used for preparing the targeted ferroferric oxide-porphyrin containing composite nanoparticles.
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Powder deliveryOrganic active ingredients +3
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Folic acidOxide +12
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