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Preparation method of targeted ferroferric oxide-porphyrin containing composite nanoparticles

A technology of composite nanoparticles and ferric oxide, which is applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problem of weak fluorescence signal intensity of photosensitizers and tumor tissue selection. The problem of low sexual uptake and high cumulative effect of photosensitizers can achieve the effect of inhibiting tumor metastasis, improving immunity and reducing diffusion

Inactive Publication Date: 2014-02-05
HARBIN INST OF TECH
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Problems solved by technology

[0003] The present invention aims to solve the problems of photodynamic diagnosis and treatment that the fluorescent signal intensity of the photosensitizer is not strong, and the selective uptake of tumor tissue is not high, resulting in a high accumulation effect of the photosensitizer in other normal tissues such as skin, even under dark light. The problem of photochemical reaction, and the preparation method of the targeted iron ferric oxide-porphyrin composite nanoparticle provided

Method used

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  • Preparation method of targeted ferroferric oxide-porphyrin containing composite nanoparticles

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specific Embodiment approach 1

[0026] Specific embodiment one: this embodiment has the preparation method of targeted iron ferric oxide-porphyrin composite nanoparticles, specifically according to the following steps:

[0027] 1. Using FeCl 3 ·6H 2 O to prepare FeCl with a concentration of 0.1mol / L 3 solution, using FeSO 4 4H 2 O to prepare FeSO with a concentration of 0.1mol / L 4 solution;

[0028] Under the condition of nitrogen protection and mechanical stirring, according to Fe 3+ with Fe 2+ The molar ratio is 2:1, and 100mL of FeCl with a concentration of 0.1mol / L 3 solution and 50 mL of FeSO with a concentration of 0.1 mol / L 4 The solutions are mixed to obtain FeCl 3 and FeSO 4 The mixed solution of the mixed solution was adjusted to a pH value of 5 by hydrochloric acid with a concentration of 1 mol / L, and then an aqueous ammonia solution with a mass concentration of 25% was added until a black precipitate appeared in the mixed solution, and the stirring was continued for 1 hour to obtain a sol...

specific Embodiment approach 2

[0035] Embodiment 2: The difference between this embodiment and Embodiment 1 is that in Step 1, the mixture of double distilled water and ethanol with a volume ratio of 1:1 is used for washing. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0036] Embodiment 3: This embodiment is different from Embodiment 1 in that: 100 mL of double distilled water is added in step 2. Others are the same as in the first embodiment.

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Abstract

The invention discloses a preparation method of targeted ferroferric oxide-porphyrin containing composite nanoparticles, and relates to a preparation method of composite nanoparticles. The preparation method disclosed by the invention aims at solving the problems that a photosensitizer is high in accumulation effect within normal tissues and even performs a photochemical reaction under a dark light because a photosensitizer fluorescence signal is low in intensity and low in selective uptake for tumour tissues, existing in photodynamic diagnosis and therapy. The method comprises the following steps: 1, preparing magnetic ferroferric oxide nanoparticles coated by silicon dioxide; 2, preparing a porphyrin compound; 3, preparing a porphyrin compound bound by a silane reagent; 4, preparing a porphyrin-folic acid compound; and 5, preparing the targeted ferroferric oxide-porphyrin containing composite nanoparticles. The preparation method based on the magnetic ferroferric oxide-porphyrin composite nanoparticles and disclosed by the invention integrates magnetofluid thermal therapy, magnetic targeting and photodynamic therapy as a therapy means for tumours. The preparation method disclosed by the invention is used for preparing the targeted ferroferric oxide-porphyrin containing composite nanoparticles.

Description

technical field [0001] The invention relates to a method for preparing composite nanoparticles. Background technique [0002] Tumor hyperthermia has become a new "green therapy" for tumor treatment after surgery, radiotherapy and chemotherapy. Hyperthermia not only has a direct cytotoxic effect on tumor cells, but also can be used in combination with chemotherapy and radiotherapy, which can enhance the curative effect of chemotherapy and radiotherapy, improve the body's immunity, and inhibit tumor metastasis. However, the commonly used hyperthermia method is limited in clinical application because of its poor targeting ability to tumors, which can easily cause the temperature of the surrounding tissues to rise and cause damage. With the development of nanotechnology, German scholar Jordan proposed a New thermal therapy—magnetic fluid hyperthermia (MFH) has made important progress in the treatment of tumors. The advantage of this method is targeted heating, that is, tissues ...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/409A61K47/48A61K47/04A61K47/22A61K41/00A61P35/00
Inventor 郭喜明郭斌陈磊
Owner HARBIN INST OF TECH
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