A kind of preparation method of adsorbent for selective separation of ciprofloxacin in water environment

A technology for ciprofloxacin and water separation, applied in chemical instruments and methods, other chemical processes, etc., can solve the problem of deep embedding of active sites, poor adsorption-desorption kinetics, mass transfer and charge transfer Slow kinetic rate and other problems, to achieve the effect of reducing non-specific adsorption, fast adsorption kinetic properties, and polymer recognition performance

Inactive Publication Date: 2016-01-20
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are still some defects in the traditional molecular imprinting technology as a whole, such as too deep embedding of active sites, slow kinetic rate of mass transfer and charge transfer, poor kinetic performance of adsorption-desorption, etc.

Method used

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  • A kind of preparation method of adsorbent for selective separation of ciprofloxacin in water environment
  • A kind of preparation method of adsorbent for selective separation of ciprofloxacin in water environment
  • A kind of preparation method of adsorbent for selective separation of ciprofloxacin in water environment

Examples

Experimental program
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Effect test

Embodiment 1

[0043] (1) Preparation of yeast-brominated composite material

[0044] Disperse 2g of activated yeast in 20mL of dichloromethane, then add 2mL of triethylamine, ice-bath for 10min, pass through N 2 After deoxygenation, 1 mL of 2-bromoisobutyryl bromide was added dropwise, and reacted at room temperature for 8 h. The reaction product was first washed three times with dichloromethane, then washed three times with absolute ethanol, and finally washed at 50 o C in a vacuum oven for 12 h.

[0045] (2) Preparation of ciprofloxacin surface imprinted polymers (MIPs)

[0046] Add 0.5 g of Tween-20 and 25 mL of distilled water into a 100 mL three-neck flask, ultrasonicate for 2 min, and then stir until no bubbles are generated. Then, 0.125 mol of ciprofloxacin, 0.5 mol of methacrylic acid, 0.5 mol of hydroxyethyl methacrylate, 3 mol of ethylene glycol di(methacrylate) ester and 0.25 g of yeast-brominated composite material were added to the emulsion system. The mixture was sonicated...

Embodiment 2

[0054] (1) Preparation of yeast-brominated composite material

[0055] Disperse 2.5g of activated yeast in 50mL of dichloromethane, then add 3mL of triethylamine, ice-bath for 20min, pass N 2 After deoxygenation, 3 mL of 2-bromoisobutyryl bromide was added dropwise, and reacted at room temperature for 10 h. The reaction product was first washed three times with dichloromethane, then washed three times with absolute ethanol, and finally washed at 50 o C in a vacuum oven for 12 h.

[0056] (2) Preparation of ciprofloxacin surface imprinted polymers (MIPs)

[0057] Add 0.6g of Tween-20 and 36mL of distilled water into a 100mL three-neck flask, sonicate for 5min, and then stir until no bubbles are generated. Then add 0.2mol ciprofloxacin, 0.6mol methacrylic acid, 0.6mol hydroxyethyl methacrylate, 4.8mol ethylene glycol di(methacrylate) ester and 0.25g yeast bromine composite material to the above emulsion system . The mixture was sonicated for 10 min to obtain a pre-polymeriz...

Embodiment 3

[0065] (1) Preparation of yeast-brominated composite material

[0066] Disperse 3g of activated yeast in 75mL of dichloromethane, then add 4mL of triethylamine, ice-bath for 40min, pass through N 2 After deoxygenation, 8 mL of 2-bromoisobutyryl bromide was added dropwise, and reacted at room temperature for 15 h. The reaction product was first washed three times with dichloromethane, then washed three times with absolute ethanol, and finally washed at 50 o C in a vacuum oven for 12 h.

[0067] (2) Preparation of ciprofloxacin surface imprinted polymers (MIPs)

[0068] Add 0.8g of Tween-20 and 52mL of distilled water into a 100mL three-neck flask, sonicate for 10min, and then stir until no bubbles are generated. Then, 0.25 mol of ciprofloxacin, 1 mol of methacrylic acid, 1 mol of hydroxyethyl methacrylate, 10 mol of ethylene glycol di(methacrylate) ester and 0.25 g of yeast-brominated composite material were added to the emulsion system. The mixture was sonicated for 10 min...

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Abstract

The invention relates to a preparation method of a novel adsorbent for selectively separating ciprofloxacin in water environment, belonging to the technical field of environmental material preparation. The present invention utilizes commercialized dry yeast as a matrix material, first modifies it into a composite material with an initiating agent, then uses ciprofloxacin as a template, and methacrylic acid and hydroxyethyl methacrylate as functional monomers , ethylene glycol di(methacrylate) ester as cross-linking agent, cuprous bromide as catalyst, using surface-initiated atom transfer radical polymerization method, synthesized molecularly imprinted adsorption on the surface of yeast in a green and environment-friendly emulsion system agent. Static adsorption experiments were used to study the adsorption equilibrium, kinetics and selective recognition performance of the prepared imprinted adsorbent. The results show that the yeast surface imprinted adsorbent obtained by the present invention has fast adsorption kinetic properties and superior recognition performance for ciprofloxacin in water environment.

Description

technical field [0001] The invention relates to a preparation method of a novel adsorbent for selectively separating ciprofloxacin in water environment, in particular, yeast is used as a matrix material, ciprofloxacin is used as a template, methacrylic acid (MAA) and hydroxyethyl methacrylate (HEMA) is a functional monomer, ethylene glycol di(methacrylate) (EGDMA) is a crosslinking agent, cuprous bromide (CuBr) is a catalyst, and atom transfer radical polymerization is used in a green and friendly emulsion system A method for synthesizing molecularly imprinted polymers on the surface of ciprofloxacin belongs to the technical field of environmental material preparation. Background technique [0002] Ciprofloxacin belongs to the third-generation fluoroquinolone antibiotics. Due to its broad antibacterial spectrum, good absorption, high blood concentration, rapid decomposition to various tissues, and long half-life, it is widely used in human medicine and animal husbandry. How...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/26B01J20/30
Inventor 王娟孟敏佳戴江栋宋志龙李春香闫永胜
Owner JIANGSU UNIV
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