Method for constructing functionalized surface and interface by polydopamine coating layer

A technology of polydopamine and functionalization, which is applied in the direction of coatings, types of packaging items, special packaging items, etc., can solve the problems that the dopamine content does not reach the ideal ratio, and the functional groups are difficult to combine, so as to achieve good modification effect and high density. high effect

Active Publication Date: 2014-04-23
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of dopamine in artificially synthesized functional polymers does not reach the ideal

Method used

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  • Method for constructing functionalized surface and interface by polydopamine coating layer
  • Method for constructing functionalized surface and interface by polydopamine coating layer
  • Method for constructing functionalized surface and interface by polydopamine coating layer

Examples

Experimental program
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Effect test

Example Embodiment

[0031] Preparation of polydopamine coating: (1) Configure fresh dopamine aqueous solution; (2) Immerse the substrate to be modified into the freshly configured dopamine aqueous solution, the auto-polymerization time of dopamine is 15~24h, the temperature is 15~35℃ . (3) Take out the substrate to be modified, rinse the dopamine and polydopamine that are not firmly bonded to the surface of the substrate with a large amount of distilled water, and let it dry naturally at room temperature.

[0032] The preparation of functional polymers containing active ester groups was carried out with reference method (Macromolecular Bioscience 2012, 12:979-985). The reaction process is as follows:

[0033]

[0034] Dissolve the polymerizable monomers containing active ester groups, phosphorylcholine groups (PC), and polyethylene glycol (PEG) in absolute ethanol according to the designed ratio, and then add them to a three-necked flask. The AIBN initiator undergoes free radical random polymerizati...

Example Embodiment

[0036] Example 1

[0037] Polytetrafluoroethylene (PTFE) substrate surface forms a polydopamine coating: configure a Tris-HCl dopamine buffer with a concentration of 2mg / ml pH=8.5, and immerse a 2cm×2cm PTFE sheet into the above solution. Dopamine automatically adheres and polymerizes at 29°C for 24 hours, takes out the film base, rinses it with distilled water 5 times, and air-dryes to obtain a polydopamine coating. The dynamic contact angle was measured, the average advancing angle was 61 ± 5°, and the average receding angle was 15 ± 2°.

Example Embodiment

[0038] Example 2

[0039] Polycarbonate (PC) substrate surface forms a polydopamine coating: configure a 2mg / ml pH=8.5 Tris-HCl dopamine buffer solution, and immerse a 2cm×2cm PC base in the above solution. Dopamine automatically adheres and polymerizes at ℃ for 24h, takes out the film base, rinses it with distilled water 8 times, and air-dryes to obtain a polydopamine coating. Determination of dynamic contact angle ( figure 1 ), the average forward angle is 58 ± 5°, and the average backward angle is 11 ± 2°. When heated in hot water at 90°C for 3 hours, the dynamic contact angle did not change significantly. X-ray photoelectron spectroscopy showed that the characteristic peak of N element appeared after dopamine was coated on the PC substrate ( figure 2 ), which proved that a polydopamine layer was formed on the surface of the PC base.

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Abstract

The invention discloses a method for constructing a functionalized surface and interface by a polydopamine coating layer. The method comprises the following steps: (1) dipping a to-be-modified base material into a dopamine aqueous solution, and automatically forming the polydopamine coating layer on the material surface; (2) preparing an active ester group-containing functionalized polymer; and (3) carrying out an amidation reaction of the active ester group-containing functionalized polymer with the polydopamine coating layer, and carrying out bonding fixation of the functionalized polymer on the material surface, so as to achieve functional modification of the material surface. The method takes the dopamine crosslinking layer having superstrong adhesion performance as a transition layer, is almost suitable for surface modification of any base material, also can overcome a problem that the artificially synthesized functionalized polymer is limited by the dopamine content, and constructs a biomimetic surface having stronger stability.

Description

technical field [0001] The invention relates to a method for constructing a functionalized surface interface through a polydopamine coating, and belongs to the technical field of biomedical polymer materials. Background technique [0002] In the field of biomedical devices, good blood compatibility is the basic prerequisite for biomedical materials implanted in the body to function. Therefore, the ability to introduce stable and high-density anticoagulant biogroups on the surface of materials is considered to be the most direct method to solve a series of problems such as protein adsorption and blood coagulation after the substrate comes into contact with the human body. [0003] Polyethylene glycol (PEG) is highly hydrophilic, has a large hydrodynamic volume in aqueous solution, and is not immunogenic. After introducing PEG chains on the surface, a spatial barrier can be created around the modified substrate, effectively inhibiting protein adsorption and platelet adhesion....

Claims

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Application Information

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IPC IPC(8): A61L33/06C08J7/12C08J7/04
Inventor 邵香君赵慕华宫永宽
Owner NORTHWEST UNIV
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