Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for constructing functionalized surface and interface by polydopamine coating layer

A technology of polydopamine and functionalization, which is applied in the direction of coatings, types of packaging items, special packaging items, etc., can solve the problems that the dopamine content does not reach the ideal ratio, and the functional groups are difficult to combine, so as to achieve good modification effect and high density. high effect

Active Publication Date: 2014-04-23
NORTHWEST UNIV
View PDF6 Cites 66 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of dopamine in artificially synthesized functional polymers does not reach the ideal ratio, and it is difficult for the functional groups to be stably bonded to the surface of the substrate.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for constructing functionalized surface and interface by polydopamine coating layer
  • Method for constructing functionalized surface and interface by polydopamine coating layer
  • Method for constructing functionalized surface and interface by polydopamine coating layer

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0031] Preparation of polydopamine coating: (1) prepare fresh dopamine aqueous solution; (2) immerse the substrate to be modified into freshly prepared dopamine aqueous solution, dopamine automatic polymerization time is 15~24h, temperature is 15~35℃ . (3) Take out the substrate to be modified, rinse the dopamine and polydopamine that are not firmly bound to the surface of the substrate with a large amount of distilled water, and let it dry naturally at room temperature.

[0032] The preparation of functional polymers containing active ester groups was carried out by reference method (Macromolecular Bioscience 2012, 12:979-985). Its reaction process is as follows:

[0033]

[0034] Dissolve the polymerizable monomers containing active ester groups, phosphorylcholine groups (PC), and polyethylene glycol (PEG) in absolute ethanol according to the designed ratio, add them to the three-necked flask, blow nitrogen to remove oxygen, and add AIBN initiators perform free radical ...

Embodiment 1

[0037] Polydopamine coating is formed on the surface of polytetrafluoroethylene (PTFE) substrate: configure Tris-HCl dopamine buffer solution with a concentration of 2mg / ml pH=8.5, immerse the PTFE substrate with a length of 2cm×2cm into the above solution, and Dopamine was auto-adhesively polymerized at 29°C for 24 hours. After the film base was taken out, it was rinsed with distilled water for 5 times and dried naturally to obtain a polydopamine coating. The dynamic contact angle was measured, and the average advancing angle was 61 ± 5°, and the average receding angle was 15 ± 2°.

Embodiment 2

[0039] Form a polydopamine coating on the surface of a polycarbonate (PC) substrate: configure a Tris-HCl dopamine buffer solution with a concentration of 2mg / ml pH=8.5, and immerse a PC sheet substrate with a length of 2cm×2cm into the above solution, at 32 The dopamine was auto-adhesively polymerized at ℃ for 24 hours. After taking out the film base, it was rinsed with distilled water for 8 times and dried naturally to obtain a polydopamine coating. Determination of the dynamic contact angle ( figure 1 ), the average advancing angle was 58 ± 5°, and the average retreating angle was 11 ± 2°. After heating in hot water at 90℃ for 3h, the dynamic contact angle did not change significantly. X-ray photoelectron spectroscopy showed that the characteristic peak of N element appeared after dopamine was coated on the PC substrate ( figure 2 ), proving the formation of a polydopamine layer on the surface of the PC sheet.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for constructing a functionalized surface and interface by a polydopamine coating layer. The method comprises the following steps: (1) dipping a to-be-modified base material into a dopamine aqueous solution, and automatically forming the polydopamine coating layer on the material surface; (2) preparing an active ester group-containing functionalized polymer; and (3) carrying out an amidation reaction of the active ester group-containing functionalized polymer with the polydopamine coating layer, and carrying out bonding fixation of the functionalized polymer on the material surface, so as to achieve functional modification of the material surface. The method takes the dopamine crosslinking layer having superstrong adhesion performance as a transition layer, is almost suitable for surface modification of any base material, also can overcome a problem that the artificially synthesized functionalized polymer is limited by the dopamine content, and constructs a biomimetic surface having stronger stability.

Description

technical field [0001] The invention relates to a method for constructing a functionalized surface interface through a polydopamine coating, and belongs to the technical field of biomedical polymer materials. Background technique [0002] In the field of biomedical devices, good blood compatibility is the basic prerequisite for biomedical materials implanted in the body to function. Therefore, the ability to introduce stable and high-density anticoagulant biogroups on the surface of materials is considered to be the most direct method to solve a series of problems such as protein adsorption and blood coagulation after the substrate comes into contact with the human body. [0003] Polyethylene glycol (PEG) is highly hydrophilic, has a large hydrodynamic volume in aqueous solution, and is not immunogenic. After introducing PEG chains on the surface, a spatial barrier can be created around the modified substrate, effectively inhibiting protein adsorption and platelet adhesion....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L33/06C08J7/12C08J7/04
Inventor 邵香君赵慕华宫永宽
Owner NORTHWEST UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com