Moldable bone repairing material for bone repairing and preparation method thereof

A bone repair and plastic technology, applied in the field of materials, can solve problems such as unsatisfactory performance, mismatch between material degradation and bone replacement speed, inflammatory response, etc., to achieve excellent molding effect, suitable curing molding time, and promote the effect of aggregation

Active Publication Date: 2015-05-20
北京科健生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problems of inflammatory reaction, immune rejection reaction, mismatch between material degradation and bone replacement speed, and unsatisfactory performance that often occur during bone repair, the present invention provides a plastic bone repair material for bone repair

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1) Grinding and refining of autologous bone meal

[0033] The patient's own bone powder is ground at low temperature, refined and sieved to obtain bone powder particles with an average diameter of 50-100 μm for use.

[0034] 2) Preparation of plastic bone repair materials

[0035]Mix 20 parts of α-calcium sulfate hemihydrate (with a particle size of 50-100 μm) with a uniform particle size, 20 parts of hydroxyapatite, and 30 parts of bioactive mineral powder with autologous bone meal particles (with a particle size of 50-100 μm) ) 30 parts were uniformly mixed, and a polyoxyethylene-polyoxypropylene-polyoxyethylene (PEO-PPO-PEO) tri-block copolymer with a concentration of 0.3g / ml was used (the degree of polymerization of the copolymer was 2500-50000, and the average molecular weight was 105,000~2,100,000) hydrogel, which contains 10% sodium hyaluronate gel with a mass concentration of 1%, and can be fully adjusted according to a liquid-solid ratio of 1:1 at 0°C to obtai...

Embodiment 2

[0037] 1) Grinding and refining of autologous bone meal

[0038] The patient's own bone powder is ground at low temperature, refined and sieved to obtain bone powder particles with an average diameter of 80-120 μm for use.

[0039] 2) Preparation of plastic bone repair materials

[0040] Mix 15 parts of α-calcium sulfate hemihydrate with uniform crystal shape (particle size 5-50 μm), 25 parts of hydroxyapatite, 150 parts of bioactive mineral powder (particle size 20-100 μm) and autologous bone powder Mix 45 parts of particles evenly, use polyoxyethylene-polyoxypropylene-polyoxyethylene (PEO-PPO-PEO) tri-block copolymer with a concentration of 0.3g / ml (the degree of polymerization of the copolymer is 2500-50000, and the average molecular weight is 105000~2100000) hydrogel, which contains 15% sodium hyaluronate solution with a mass concentration of 1%, and can be fully adjusted according to the solid-liquid ratio of 1:2 at 0°C to obtain a plastic bone repair material, which is ...

Embodiment 3

[0042] 1) Grinding and refining of autologous bone meal

[0043] The patient's own bone powder is ground at low temperature, refined and sieved to obtain bone powder particles with an average diameter of 80-120 μm for use.

[0044] 2) Preparation of plastic bone repair materials

[0045] Mix 15 parts of α-calcium sulfate hemihydrate (particle size: 200-250 μm) with uniform particle size, 25 parts of hydroxyapatite, and 20 parts of bioactive mineral powder (particle size: 200-250 μm) with autologous bone powder 40 parts of granules were uniformly mixed, and a polyoxyethylene-polyoxypropylene-polyoxyethylene (PEO-PPO-PEO) tri-block copolymer with a concentration of 0.8g / ml was used (the degree of polymerization of the copolymer was 2500-50000, and the average molecular weight was 105,000~2,100,000) hydrogel, which contains 15% chitosan solution with a mass concentration of 1.5%, and can be fully reconciled with solid powder at a solid-liquid ratio of 1:1 at 0°C to obtain a plas...

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Abstract

The invention provides a moldable bone repairing material for bone repairing. The material is prepared from the following raw materials in parts by weight: 20-90 parts of alpha-calcium sulfate hemihydrate and hydroxyapatite, 20-40 parts of bioactive mineral powder, 10-80 parts of autologous bone powder particles or DBM (demineralized bone matrix) particles, and hydrogel, wherein the ratio of hydrogel to the total usage of the raw materials is 1:0.5-1:15, the hydrogel is optimally PEO-PPO-PEO (polyoxyethylene-polyoxypropylene-polyoxyethylene) segmented copolymer solution. The prepared moldable bone repairing material for bone repairing is applicable to in-situ curing after wound injection and in-vitro quick curing for bone repairing, wherein all components are proved to be degradable materials with excellent biocompatibility.

Description

technical field [0001] The invention relates to the field of materials, in particular to a plastic bone repair material for bone repair. Background technique [0002] The mixture of calcium sulfate hemihydrate and hydroxyapatite is a commonly used defect repair material in orthopedics. However, a large number of clinical experiments have shown that its repair effect has certain problems in terms of morphology, inflammatory response, and repair rate, which need to be improved. [0003] Chinese application CN1686577 discloses a biological composite material and its preparation method and application. The biocomposite material is composed of bone matrix gelatin and calcium sulfate hemihydrate, the weight ratio of which is 1:1-3. The biocomposite material is molded by adding distilled water or physiological saline under normal pressure to make a plastic bio-bone substitute material. Implanted in the body, the artificial bone will simultaneously exert osteoinductive activity an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/52A61L27/54A61L27/58
Inventor 李次会常丽张国强
Owner 北京科健生物技术有限公司
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