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Amphipathic polymer, preparation method thereof, composite nano medicine carrier and preparation method thereof

An amphiphilic polymer and nano-drug carrier technology, applied in the field of polymers, can solve the problems of uncontrollable time and location of drug release, prolonging drug release cycle, etc.

Active Publication Date: 2014-07-16
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Vallet-Regi et al. studied the loading of mesoporous silica nanoparticles with two pore sizes on ibuprofen, and studied the drug loading and drug release behavior of mesoporous silica nanoparticles. The study found that: mesoporous silica nanoparticles Silica nanoparticles have a higher drug loading, which can prolong the release period of the drug, and with the increase of the pore size, the release rate of the drug is accelerated, but it cannot control the time and location of drug release.

Method used

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  • Amphipathic polymer, preparation method thereof, composite nano medicine carrier and preparation method thereof
  • Amphipathic polymer, preparation method thereof, composite nano medicine carrier and preparation method thereof

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preparation example Construction

[0042] The invention provides a kind of preparation method of amphiphilic polymer, comprises the following steps:

[0043] Under the effect of initiator, spiropyran methyl methacrylate, polyethylene glycol methyl methacrylate and N-succinimide methacrylate are polymerized in a solvent to obtain a polymerization solution. The polymerization reaction solution includes a polymerization product;

[0044] Precipitating the polymerization product from the polymerization reaction solution to obtain an amphiphilic polymer precursor;

[0045] performing a conjugation reaction with the amphiphilic polymer precursor and folic acid to obtain an amphiphilic polymer having a structure shown in formula I;

[0046] Formula I;

[0047] In formula I, the x, y and z are all natural numbers, 1≤x≤5, 3≤y≤15, 1≤z≤3;

[0048] Said n is the degree of polymerization, 5≤n≤20.

[0049] The present invention under the effect of initiator, spiropyran methyl methacrylate (SPMA), polyethylene glycol me...

Embodiment 1

[0118]Dissolve 235mg of yttrium acetate, 105mg of ytterbium acetate and 1.73mg of thulium acetate in a mixed solvent of 15mL of octadecene and 6mL of oleic acid, heat the resulting mixed solution to 120°C under vacuum and stir for 30min; under nitrogen protection, cool down To 50°C, dissolve 148mg of ammonium fluoride and 100mg of sodium hydroxide in 10mL of methanol, then add to the above mixed solution, raise the temperature to 70°C and stir for 30min to remove methanol; then raise the temperature to 300°C, react under nitrogen protection After 1.5 h, after the reaction was cooled to room temperature, ethanol was added to allow the obtained reaction product to settle down, and finally the rare earth up-conversion nanoparticle core was obtained by centrifugation, and stored in 10 mL of n-hexane for later use;

[0119] Dissolve 296mg of yttrium acetate in a mixed solvent of 15mL of octadecene and 6mL of oleic acid, heat the resulting mixed solution to 120°C under vacuum and sti...

Embodiment 2

[0135] The present invention prepares the composite nano drug carrier according to the technical scheme described in Example 1, the difference is that in this example, the SPMA is 12 mol, the MAPEG is 4 mol and the NAS is 1 mol.

[0136] The present invention carries out gel permeation chromatography analysis to the obtained amphiphilic polymer, and the results are shown in Table 1. Table 1 is the gel permeation chromatography analysis result and the amphiphilic polymer of the amphiphilic polymer obtained in Examples 2 to 4. The content of each component in the results.

[0137] The results of gel permeation chromatography analysis of the amphiphilic polymer obtained in Examples 2 to 4 of Table 1 and the content results of each component in the amphiphilic polymer

[0138]

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Abstract

The invention provides an amphipathic polymer, a preparation method thereof, a composite nano medicine carrier and a preparation method thereof. The composite nano medicine carrier comprises a chemical modification rare-earth up-conversion nanoparticle and an amphipathic polymer which covers the chemical modification rare-earth up-conversion nanoparticle, wherein the chemical modification is modification by mesoporous silica and alkyl chain. When the composite nano medicine carrier is radiated by near infrared ray, the near infrared ray is converted by the rare-earth up-conversion nano-particle to be high-frequency ultraviolet light, the amphipathic polymer is converted by the ultraviolet light to a hydrophilic polymer, so that the amphipathic polymer is separated from the surface of the hydrophobic chemical modification rare-earth up-conversion nano-particle, and the medicine in the mesoporous silico pores can be released; folic acid targeted groups are modified on side chains of the amphipathic polymer, so that the composite nano medicine carrier has a good concentration effect on the tumor cells with high expression to folic acid receptors, and the targeted treatment on the cancer can be realized.

Description

technical field [0001] The invention belongs to the technical field of polymers, and in particular relates to an amphiphilic polymer, a preparation method thereof, a composite nano drug carrier and a preparation method thereof. Background technique [0002] Drug carriers can change the way the drug enters the organism and its distribution in the body, and deliver the drug. Nano-drug carrier is a nano-scale drug carrier delivery system. Nano-drug carriers have the advantages of improving the absorption efficiency of insoluble drugs, realizing the controlled release of drugs, reducing drug side effects, and increasing blood drug concentrations. In recent years, they have attracted extensive attention from scholars at home and abroad. [0003] In the prior art, nano-drug carriers are divided into nanoparticles, nano-emulsions, solid lipid nanoparticles, nano-micelles, nano-micelles, nano-liposomes, etc. according to their structure. Particles have the advantages of uniform me...

Claims

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Application Information

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IPC IPC(8): C08F290/06C08F220/36C08F220/28C08F8/32A61K47/32A61K47/04A61K41/00A61P35/00
Inventor 路建美李娜君邢庆健
Owner SUZHOU UNIV
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