Fluorescent magnetic nanoparticle for hypochlorous acid detection and synthetic method thereof

A technology of magnetic nanoparticles and synthesis methods, applied in the fields of nanomaterials and chemical sensors, can solve the problems of complex and cumbersome synthesis process of organic fluorescent probes, single detection means and functions, and achieve low cost, simple preparation process and high sensitivity. Effect

Inactive Publication Date: 2014-07-30
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, on the one hand, these detection methods involve complex and cumbersome organic fluores...

Method used

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  • Fluorescent magnetic nanoparticle for hypochlorous acid detection and synthetic method thereof
  • Fluorescent magnetic nanoparticle for hypochlorous acid detection and synthetic method thereof
  • Fluorescent magnetic nanoparticle for hypochlorous acid detection and synthetic method thereof

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Effect test

Embodiment 1

[0060] The synthetic method of the fluorescent magnetic nanoparticle that is used for hypochlorous acid detection of the present invention comprises the following steps:

[0061] a.Fe 3 o 4 Synthesis:

[0062] Weigh a certain amount of FeCl 3 ·6H 2 O, anhydrous sodium acetate and ethylene glycol, wherein, FeCl 3 ·6H 2 The ratio of O to anhydrous sodium acetate and ethylene glycol is 1.0mmol: 10mmol: 9mL, and then the FeCl 3 ·6H 2 O and anhydrous sodium acetate were dissolved in ethylene glycol, mixed evenly, and then placed in a hydrothermal synthesis kettle at 200°C for 12 hours of reaction. After the reaction was completed, it was cooled to room temperature, and the black precipitate was separated by centrifugation, and then the After washing with absolute ethanol and drying under reduced pressure, Fe 3 o 4 ;

[0063] b.Fe 3 o 4 mSiO 2 nSiO 2 Synthesis:

[0064] 1) take by weighing a certain amount of Fe that step a obtains 3 o 4 , and then by dilute hydroch...

Embodiment 2

[0073] The synthetic method of the fluorescent magnetic nanoparticle that is used for hypochlorous acid detection of the present invention comprises the following steps:

[0074] a.Fe 3 o 4 Synthesis:

[0075] Weigh a certain amount of FeCl 3 ·6H 2 O, anhydrous sodium acetate and ethylene glycol, wherein, FeCl 3 ·6H 2 The ratio of O to anhydrous sodium acetate and ethylene glycol is 1.0mmol: 8mmol: 8mL, and then the FeCl 3 ·6H 2 O and anhydrous sodium acetate were dissolved in ethylene glycol, mixed evenly, and then placed in a hydrothermal synthesis kettle at 200°C for 8 hours of reaction. After the reaction was completed, it was cooled to room temperature, and the black precipitate was separated by centrifugation, and then the After washing with absolute ethanol and drying under reduced pressure, Fe 3 o 4 ;

[0076] b.Fe 3 o 4 mSiO 2 nSiO 2 Synthesis:

[0077] 1) take by weighing a certain amount of Fe that step a obtains 3 o 4 , and then by dilute hydrochlo...

Embodiment 3

[0086] The synthetic method of the fluorescent magnetic nanoparticle that is used for hypochlorous acid detection of the present invention comprises the following steps:

[0087] a.Fe 3 o 4 Synthesis:

[0088] Weigh a certain amount of FeCl 3 ·6H 2 O, anhydrous sodium acetate and ethylene glycol, wherein, FeCl 3 ·6H 2 The ratio of O to anhydrous sodium acetate and ethylene glycol is 1.0mmol: 9mmol: 8.5mL, and then the FeCl 3 ·6H 2 O and anhydrous sodium acetate were dissolved in ethylene glycol, mixed evenly, and placed in a hydrothermal synthesis kettle at 200°C to react for 4 hours. After the reaction was completed, it was cooled to room temperature, and the black precipitate was separated by centrifugation, and then subjected to After washing with absolute ethanol and drying under reduced pressure, Fe 3 o 4 ;

[0089] b.Fe 3 o 4 mSiO 2 nSiO 2Synthesis:

[0090] 1) take by weighing a certain amount of Fe that step a obtains 3 o 4 , and then by dilute hydroch...

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Abstract

The invention discloses a fluorescent magnetic nanoparticle for hypochlorous acid detection and a synthetic method thereof. The synthetic method comprises the following steps: preparing a ferroferric oxide magnetic nanoparticle as a magnetic core material by adopting a solvent thermal method, coating the outer part of the magnetic core with a layer of nonporous silicon dioxide and a layer of mesoporous silicon dioxide in sequence by adopting a sol-gel method, and finally covalently modifying a magnetic mesoporous material obtained in the previous two steps with an organic fluorescent molecule capable of specifically identifying hypochlorous acid through a silane coupling agent, thus obtaining the fluorescent magnetic nanoparticle for the hypochlorous acid detection. The nanoparticle is simple in a preparation process and low in cost; the detection of high sensitivity and high selectivity of the hypochlorous acid can be realized by utilizing the remarkable enhancement of a fluorescent signal of the nanoparticle before and after recognition; and the magnetic control and separation of the magnetic nanoparticle can be realized by additionally arranging a magnetic field. The fluorescent magnetic nanoparticle and the synthetic method thereof have an important application prospect in the fields of visual tracing and imaging of the hypochlorous acid in living organisms, quantitative detection of hypochlorous acid in environmental water, clearing and the like.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials and chemical sensors, and in particular relates to a fluorescent magnetic nanoparticle for detecting hypochlorous acid and a synthesis method thereof. Background technique [0002] Life science and environmental science have become hot research areas of common concern worldwide, and the research on monitoring methods of various life phenomena and environmental pollutants has been paid more and more attention. Hypochlorous acid (HOCl) is a strong oxidizing agent that acts antimicrobially in living organisms and during water treatment. In living organisms, hypochlorous acid is an important class of reactive oxygen species (ROS), which plays a key role in many processes with important physiological and biological significance. However, the formation of excessive hypochlorous acid can induce tissue damage and cause a series of diseases such as arteriosclerosis, arthritis and even cancer. ...

Claims

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Application Information

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IPC IPC(8): C09K11/06H01F1/42G01N21/64
Inventor 张祯邓成权刘小龙
Owner XI AN JIAOTONG UNIV
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