Application of Liushen Pills in Preparation of Drugs for Prevention and Treatment of Fungal Dermatosis
A technology of Liushen pills and external medicines, applied in skin diseases, antifungal agents, drug combinations, etc., can solve the problems of long, at least ten days, as many as several months, prone to drug resistance, and large toxic and side effects. Achieve the effect of not easy to relapse, good clinical application prospects, and no drug resistance
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Embodiment 1 6
[0017] Example 1 Study on Antifungal Pharmacodynamics of Liushen Pills
[0018] 1. Materials
[0019] 1.1 Drugs
[0020] Liushen Pill Suspension: Liushen Pill (produced by Leiyunshang Pharmaceutical Co., Ltd.) is ground and added with different amounts of distilled water to make high concentration (3mg / ml), medium (1.5mg / ml), low concentration (0.75mg / ml) ) of the Liushen Pill suspension. Positive control drug: dacryline cream. Negative control drug: cream base.
[0021] 1.2 Strains
[0022] Trichophyton rubrum, Trichophyton gypsum, Epidermophyton flocculum, Microsporum canis, Candida albicans.
[0023] 1.3 Medium
[0024] Sabouraud's Modified Medium
[0025] 1.4 Test animals
[0026] White guinea pig 350g±10g, male
[0027] 1.5 Data processing
[0028] SPSS16.0 software was used for statistical analysis. Measurement data are expressed as mean ± standard deviation Indicates that the comparison between groups was performed by analysis of variance.
[0029] 2. Meth...
Embodiment 2 6
[0044] Example 2 Clinical Observation on Treatment of Athlete's Foot by Liushen Gel
[0045] 1 Materials and methods
[0046] 1.1 Clinical data
[0047] 210 cases of tinea pedis patients, according to the typical clinical symptoms and signs of the patients, and fungal microscopic examination positive cases of fungal infection of the foot, aged (24-55) years, gender is not limited, the course of disease is 14 days to 5 years, all patients adopt They were divided into treatment group and control group by random number table method, with 105 cases in each group. The general conditions, age, occupation, and physical condition of the two groups were balanced and comparable. Diagnostic criteria for tinea pedis: ①Inducement: the feet are prone to sweating, and the shoes are not breathable; ②Clinical manifestations: foot itching, desquamation and blisters, often secondary to bacterial infection due to scratching and friction; ③Fungus microscopic examination is positive. Exclusion cr...
Embodiment 3 6
[0061] Example 3 Liushen Ointment Treatment of tinea corporis Clinical Observation
[0062] 1 Materials and methods
[0063] 1.1 Clinical data
[0064] A total of 176 patients with skin diseases, clinical rash performance in line with the typical clinical features of tinea corporis, and fungal picture examination was positive, in line with the diagnostic criteria for tinea corporis. Among them, there were 106 males and 70 females; their age ranged from 22 to 67 years, with an average of 35.2 years, and the course of the disease ranged from 5 months to 5 years, with an average of 3.4 years. The patients were randomly divided into two groups, 88 cases in the treatment group and 88 cases in the control group. There was no significant difference between the two groups in terms of age, sex, course of disease, and severity of rash after statistical processing, and they were comparable. All patients did not use external antifungal and glucocorticoid hormone preparations within 4 we...
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