A kind of in vivo traceable and controllable degradable nanocomposite material and its preparation method

Abstract

The invention provides a composite material, comprising: biodegradable material and GdPO4 H2O, the composite material of the present invention comprises GdPO4 H2O and the biodegradable material, so that the obtained composite material is used as a material implanted in the body. When the alternating magnetic field is used, the temperature of the composite material can be increased, thereby accelerating the degradation rate of the composite material in the body, and realizing the controllable degradation of the composite material in the body. At the same time, the composite material provided by the invention can monitor the change of the composite material through nuclear magnetic imaging , and then realized the trace monitoring of the composite material in vivo.

Description

technical field [0001] The invention relates to the field of medical polymers, in particular to a traceable and controllable degradable nanocomposite material in vivo and a preparation method thereof. Background technique [0002] At present, the degradable biomaterials used for bone tissue engineering scaffolds and other fixed repairs include polylactic acid, polyglycolic acid, polycaprolactone, polyhydroxybutyrate, polyanhydride and their copolymers. Among them, polylactic acid-glycolic acid copolymer (PLGA) has good biocompatibility, non-toxicity, good encapsulation and film-forming properties, and is widely used in fields such as medicine. Hydroxyapatite (HA) is the main component of human bone tissue. It has excellent biocompatibility and osteoconductivity. However, the texture of HA is too brittle, and the material is easily broken. The mechanical properties are poor, and there is no sufficient strength and fatigue resistance. Therefore, the bone scaffold material pre...

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Problems solved by technology

Yunbing Wang et al. dispersed particles containing L-lactic acid into (polylactic acid) PLLA to make a scaffold material. When the scaffold was exposed to a humid environment, the degradation of the PLLA scaffold was accelerated by selecting the induction time; Yang Yuan et al. used biodegradable two The biodegradable cross-linker (BC) end-capped by bisvinyl groups and polylactic acid macromonomer (MC) functionalized with terminal double bonds are used as the backbone of the new material, with the help of the embedding of polyvinylpyrrolidone (PVP) in the water-soluble molecular segment To prepare biodegradable bone repair materials, the hydrophilic-hydrophobic micro-phase structure of the material is controlled by adjusting the composition ratio of the monomers, so as to regulate the hydrolysis rate of the local ester bond and achieve the overall degradation rate of the material; in addition, in the tracer detection In terms of implanted materials in the body, ThomasW.Gilbert et al. used isotope-labeled ECM scaffold materials to quantitatively detect the degradation products of the materials. This method is safe and sensitive, but the cycle is long and the price is expensive.

[0004] In summary, the currently studied bone tissue engineering scaffolds and other fixed repair materials made of biodegradable medical polymers have pre-designed degradation rates in terms of controllable degradation and in vivo tracer monitoring. The degradation process is relatively complicated, so it cannot be guaranteed that the material will degrade at the designed rate. If the growth rate of new bone is too fast or too slow compared with the degradation rate of the scaffold material, it is impossible to artificially control the degradation rate of the implant material at this time. Meet the needs of tissue growth and other treatments

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