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Compound sulfamonomethoxine sodium injection and preparation method thereof

A technology of methoxine sodium and compound sulfonamide, applied in the field of medicine, can solve the problem of bacteria easily producing drug resistance and the like, and achieve the effects of remarkable curative effect, stable quality and reasonable formula

Inactive Publication Date: 2015-01-14
安徽天安生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Trimethoprim is a broad-spectrum antibacterial drug, the antibacterial spectrum is similar to that of sulfa drugs, and it has the effect of inhibiting dihydrofolate reductase, but bacteria are more likely to develop drug resistance

Method used

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  • Compound sulfamonomethoxine sodium injection and preparation method thereof
  • Compound sulfamonomethoxine sodium injection and preparation method thereof
  • Compound sulfamonomethoxine sodium injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A compound sulfamethoxine sodium injection, wherein every 100ml injection mainly consists of the following components by weight: sulfamethoxine sodium 8g, trimethoprim 1g, flunixin meglumine 1g, prednisolone Songlong 0.1g, polyvinylpyrrolidone 8g, polyethylene glycol-400: 38g, sodium sulfite 0.01g, disodium edetate 0.1g, sodium hydroxide: appropriate amount, so that the pH value of the injection can be adjusted to 10.0-10.5, the balance is water for injection.

[0017] The preparation method of above-mentioned compound sulfamethoxine sodium injection comprises the following steps:

[0018] (1) Take sulfa-metamethoxine sodium, add 18 g of water for injection, stir while heating until the solution is clear, and obtain solution A.

[0019] (2) Add trimethoprim to polyethylene glycol-400, stir while heating until the solution is clear, and obtain solution B.

[0020] (3) Take polyvinylpyrrolidone and add 23 g of water for injection, stir until the solution is clear, and o...

Embodiment 2

[0026] A compound sulfamethoxine sodium injection, wherein every 100ml injection mainly consists of the following components by weight: sulfamethoxine sodium 12g, trimethoprim 3g, flunixin meglumine 3g, prednisolone Songlong 0.2g, polyvinylpyrrolidone 12g, polyethylene glycol-400: 42g, sodium sulfite 0.02g, disodium edetate 0.2g, sodium hydroxide: appropriate amount, so that the pH value of the injection can be adjusted to 10.0-10.5, the balance is water for injection.

[0027] The preparation method of above-mentioned compound sulfamethoxine sodium injection comprises the following steps:

[0028] (1) Take sulfamethoxine sodium, add 22 g of water for injection, stir while heating until the solution is clear, and obtain solution A, and the heating temperature is 80-90°C.

[0029] (2) Take trimethoprim and add polyethylene glycol-400, and stir while heating until the solution becomes clear to obtain solution B. The heating temperature is 80-90°C.

[0030] (3) Take polyvinylpy...

Embodiment 3

[0036] A compound sulfamethoxine sodium injection, wherein every 100ml injection mainly consists of the following components by weight: sulfamethoxine sodium 10g, trimethoprim 2g, flunixin meglumine 2g, prednisolone Songlong 0.15g, polyvinylpyrrolidone 10g, polyethylene glycol-400: 40g, sodium sulfite 0.015g, disodium edetate 0.15g, sodium hydroxide: appropriate amount, so that the pH value of the injection can be adjusted to 10.0-10.5, the balance is water for injection.

[0037] The preparation method of above-mentioned compound sulfamethoxine sodium injection comprises the following steps:

[0038] (1) Take sulfa-metamethoxine sodium, add 20 g of water for injection, stir while heating until the solution is clear, and obtain solution A.

[0039] (2) Add trimethoprim to polyethylene glycol-400, stir while heating until the solution is clear, and obtain solution B.

[0040] (3) Take polyvinylpyrrolidone and add 25 g of water for injection, stir until the solution is clear, ...

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Abstract

The invention relates to a compound sulfamonomethoxine sodium injection and a preparation method thereof, and belongs to the technical field of medicines. Every 100ml of injection is mainly prepared from the following components by weight: 8-12g of sulfamonomethoxine sodium, 1-3g of trimethoprim, 1-3g of flunixin meglumine, 0.1-0.2g of prednisolone, 8-12g of polyvinyl pyrrolidone, 38-42g of polyethylene glycol-400, 0.01-0.02g of sodium sulfite, 0.1-0.2g of ethylenediaminetetraacetic acid disodium salt, a proper amount of sodium hydroxide to regulate the pH value of the injection to be 10.0-10.5, and the balance of water for injection. The compound sulfamonomethoxine sodium injection is reasonable in formula, high in bioavailability, remarkable in curative effect and stable in quality, and is capable of keeping a relatively high biological activity for a long time.

Description

technical field [0001] The invention relates to a compound sulfamethoxine sodium injection and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Sulfamethoxine sodium is a relatively new generation of long-acting sulfa drugs. In terms of antibacterial effect, it ranks first among sulfa drugs. It is the sulfa drug with the strongest antibacterial effect in vivo and in vitro. Gram Positive Bacteria Both negative bacteria and negative bacteria have a strong inhibitory effect, and bacteria are slow to develop resistance to this drug. It is mainly used for various diseases caused by sensitive bacteria, Toxoplasma gondii and Eperythrozoon (such as high fever, streptococcal disease, Haemophilus parasuis disease , toxoplasmosis, swine edema disease, erythrozoonosis, infectious pleuropneumonia, Pasteurella pneumonia, etc.) and their mixed infections. [0003] Trimethoprim is a broad-spectrum antibacterial drug, and its anti...

Claims

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Application Information

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IPC IPC(8): A61K31/635A61K9/08A61P31/12A61P31/04A61P31/00A61P33/02A61K31/573A61K31/505A61K31/44
CPCA61K31/635A61K9/08A61K31/44A61K31/505A61K31/573A61K2300/00
Inventor 程贤防
Owner 安徽天安生物科技股份有限公司
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