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Artificial bezoar microcapsules, its preparation method and compound acetaminophen preparation

A technology of compound acetaminophen amine tablets and artificial bezoar, which is applied in the field of medicine, can solve problems such as difficult industrial production, low dissolution rate of Gankang, bad smell and taste, etc., and achieve improved bioavailability, reduced bad smell, and high yield and high efficiency

Active Publication Date: 2017-11-03
吉林省吴太感康药业有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Gankang, that is, the main ingredients of Compound Amantadine Tablets are: acetaminophen, amantadine hydrochloride, caffeine, chlorpheniramine maleate, and artificial bezoar; There is no requirement for the phenomenon of causing bad smell, but in the actual market sales process, some consumers raised one of the bad smell in the finished product, which often leads to adverse reactions such as nausea and vomiting when taking it
In order to improve the bad smell of Gankang, the Chinese invention patent with publication number CN102488712A discloses a method of removing the bad smell of Gankang by using artificial bezoar bezoar β-cyclodextrin inclusion technology, which can cover up the bad smell of artificial bezoar , but this method has strict requirements on process conditions during scale-up production, and it is difficult to industrialize production
More importantly, the dissolution rate of Gankang prepared by this method is low

Method used

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  • Artificial bezoar microcapsules, its preparation method and compound acetaminophen preparation
  • Artificial bezoar microcapsules, its preparation method and compound acetaminophen preparation
  • Artificial bezoar microcapsules, its preparation method and compound acetaminophen preparation

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preparation example Construction

[0029] The present invention also provides a kind of preparation method of artificial bezoar microcapsules, comprising:

[0030] a) adding the organic solution of the core material to the aqueous solution of the wall material to form a suspension;

[0031] b) Homogenizing and spray-drying the suspension in sequence to obtain artificial bezoar microcapsules, the core material is artificial bezoar, and the wall material is modified starch.

[0032] In the present invention, firstly, the organic solution of the core material is added to the aqueous solution of the wall material to form a suspension. The core material is artificial bezoar, and the wall material is modified starch, preferably octenyl succinic esterified starch. In the present invention, the organic solution of the core material is preferably an ethanol solution of the core material, and it is sufficient to dissolve the core material in ethanol. In the ethanol solution of the core material, the mass ratio of the co...

Embodiment 1

[0065] Heat the deionized water to 82°C, add 300g of octenyl succinic esterified starch to the stirrer until it is completely dissolved, and then cool it to room temperature as a wall material solution;

[0066] Weigh 50g of artificial bezoar, dissolve it in 250mL of ethanol, add it to the wall material solution, heat in a water bath at 25°C, and stir at 300r / min to form a suspension evenly;

[0067] Use a high-speed disperser to disperse at a speed of 22000r / min for 1min, then perform high-pressure homogenization twice, the first-stage homogeneous pressure is 30MPa, and the second-stage homogeneous pressure is 5MPa; then use a high-speed centrifugal spray dryer for spray drying. The inlet air temperature was 195°C, the outlet air temperature was 95°C, and the feeding rate of the peristaltic pump was 30r / min, and artificial bezoar microcapsules were prepared.

Embodiment 2

[0069] Heat deionized water to 82°C, add 600g of octenyl succinic esterified starch to the stirrer until it is completely dissolved, and cool to room temperature as a wall material solution;

[0070] Weigh 100g of artificial bezoar, dissolve it in 500mL of ethanol, add it to the wall material solution, heat in a water bath at 25°C, and stir at 300r / min to form a suspension evenly;

[0071] Use a high-speed disperser to disperse at a speed of 22000r / min for 1min, then perform high-pressure homogenization twice, the first-stage homogeneous pressure is 30MPa, and the second-stage homogeneous pressure is 5MPa; then use a high-speed centrifugal spray dryer for spray drying. The inlet air temperature was 195°C, the outlet air temperature was 95°C, and the feeding rate of the peristaltic pump was 30r / min, and artificial bezoar microcapsules were prepared.

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Abstract

The invention provides an artificial bezoar microcapsule, comprising: a core material and a wall material wrapping the core material, the core material is artificial bezoar, and the wall material is modified starch. The invention also provides a preparation method of artificial bezoar microcapsules. The invention also provides a compound acetaminophen preparation. The artificial bezoar microcapsule prepared by using the artificial bezoar as the core material and the modified starch as the wall material can not only cover the bad smell of the artificial bezoar, but also has a higher dissolution rate. In the invention, the organic solution of the core material is added to the aqueous solution of the wall material to form a suspension, and then homogenized and spray-dried in sequence to obtain artificial bezoar microcapsules, which realizes the microencapsulation of solid substances, and the microcapsule yield and efficiency Both are higher. The artificial bezoar bezoar microcapsules provided by the invention can be used to prepare compound acetaminophen tablets, which not only reduces the bad smell of the compound acetaminophen tablets, but also makes the compound acetaminophen tablets have higher dissolution rate and bioavailability .

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an artificial bezoar microcapsule, a preparation method thereof and a compound aminophenamine preparation. Background technique [0002] Artificial bezoar is made from bovine bile powder, cholic acid, hyodeoxycholic acid, taurine, bilirubin, cholesterol, trace elements, etc. It is generally yellow loose powder, or irregular lead brown or golden yellow on the surface. Spherical and square, it has the characteristics of light quality, slightly fragrant and slightly fishy smell, slightly sweet and bitter taste, and no cooling feeling after the entrance. Artificial bezoar is bitter and cold in nature and has the functions of clearing heat and detoxification, eliminating phlegm and relieving throat. It is often used for fever, sore throat, and excessive saliva. Modern pharmacological studies have proved that bezoar has antipyretic and sedative, antitussive and expectora...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K35/413A61K47/36A61K9/20A61K31/522A61K31/4402A61K31/167A61K31/13
Inventor 邢福涛
Owner 吉林省吴太感康药业有限公司
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