Nemadectin purification method

Abstract

The invention provides a nemadectin purification method. The method comprises the steps that: (1) a nemadectin crude product is provided; (2) the nemadectin crude product is mixed with liquid-state organic salt, and filtering is carried out, such that a filtrate is obtained; (3) the obtained filtrate is mixed with C5-C20 alkane, such that washing is carried out; and separation is carried out, such that a liquid-state organic salt-phase solution is obtained; and (4) the liquid-state organic salt-phase solution obtained in the step (3) is subjected to cooling crystallization, such that nemadectin is obtained. Compared with prior arts, the method has the following advantages: defects of current methods such as resin absorption separation are overcome; the purity of obtained nemadectin is high; the method is simple and feasible; energy consumption is low; cost is low; and single processing capacity is high. The method is suitable for industrialized mass productions.

Description

technical field

[0001] The invention belongs to the field of pharmacy, and in particular relates to a method for purifying nemoctine. Background technique

[0002] Nemadectin is a sixteen-membered macrolide antibiotic produced by Streptomyces cyaneogriseus sp. Like mycin, it exhibits good antiparasitic activity. Nimoctine is white powder, soluble in methanol, ethanol, dichloromethane, dimethyl sulfoxide, formamide dimethylamide. Molecular formula of Nimoctin: C 36 h 52 o 8 , molecular weight: 312.3705, molecular formula as shown in formula I below:

[0003]

[0004] In the 1990s, the area under the control of agricultural diseases and insect pests in my country was 270 million ha 2 , 90% of the use of pesticides for prevention and control, reducing food loss of 31.5 billion catties; a large number of chemical pesticides have a great impact on the environment, and even caused serious pollution, endangering people's health. Nimoctine, as an antiparasitic antibiotic, ...

Images