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Applications of bionic silicon-calcium hybrid collagen scaffold material within fiber

A technology of collagen scaffolds and biomimetic silicon, applied in medical science, prostheses, etc., can solve the problems of mismatching new tissue growth in degradation rate, slow material osseointegration, etc., and achieve good biological safety, strong modifiability, The effect of a good internal environment

Active Publication Date: 2015-01-28
博纳格科技(天津)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the process of further promoting the transformation and application of the material, the inventors found that due to the amorphous state of silica in the fiber, the mechanical properties of the material could not match that of natural bone tissue, and there was an incompatibility between the degradation rate in vivo and the growth of new tissue. Problems such as matching and slow osseointegration of materials need to be solved urgently

Method used

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  • Applications of bionic silicon-calcium hybrid collagen scaffold material within fiber
  • Applications of bionic silicon-calcium hybrid collagen scaffold material within fiber
  • Applications of bionic silicon-calcium hybrid collagen scaffold material within fiber

Examples

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Embodiment 1

[0037] This embodiment is the construction of the biomimetic silicified collagen scaffold material in the fiber:

[0038] (1) Take 500g of fresh beef tendon, remove fascia, fat and other impurities, and cut into thin slices; add the cut tendon slices to 250mL 0.5% protease digestion solution, digest at a constant temperature of 37°C for 3 hours, use 100mL 0.3g / L H 2 o 2 The solution terminates the enzyme digestion reaction, rinses repeatedly with distilled water and then air-dries; add 100mL 0.1% acetic acid solution to 100g dried tendons to swell, stir evenly and centrifuge to remove impurities; Purity; Concentrate with polyethylene glycol to prepare a collagen solution with a final concentration of 20mg / mL; pre-cool at -20°C for 2 hours, and freeze-dry in a positive air freeze dryer for 24 hours to make a porous collagen sponge; use 0.3 M 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide / 0.06M N-hydroxysuccinimide solution was used to crosslink and fix the collagen sponge for...

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Abstract

The present invention relates to applications of a bionic silicon-calcium hybrid collagen scaffold material within fiber, specifically to the osteoclastogenesis inhibition application of the bionic silicon-calcium hybrid collagen scaffold material within fiber, and the application of the bionic silicon-calcium hybrid collagen scaffold material within fiber as the bone defect repair material. According to the present invention, calcium ions and silicic acid released by the bionic silicon-calcium hybrid collagen scaffold material within fiber under the body fluid environment can promote osteogenic differentiation of the mesenchymal stem cells and induce the mesenchymal stem cells to secrete a large number of osteoprotegerin so as to provide effects of osteoclast activation inhibiting and bone damage function inhibiting, and in the late stage of implantation, the secretion of the osteoprotegerin returns to the normal level, and the activation of the osteoclasts is beneficial to the normal processing of the bone remodeling process.

Description

technical field [0001] The invention belongs to the field of tissue engineering scaffold materials, and relates to a method of using the principle of bionic mineralization to realize the orderly deposition of two minerals, silicon dioxide and hydroxyapatite, in collagen fibers, and constructs a scaffold with good mechanical properties. A novel intrafibrillar biomimetic calcium-silica hybrid collagen scaffold material with osteogenic properties. Background technique [0002] Type I collagen is the main organic matrix in hard tissues such as vertebrate bones and teeth. It has the characteristics of extensive sources, simple synthesis, good biocompatibility, and strong toughness. It is a commonly used scaffold material in the field of tissue engineering, but it is easy to degrade. The characteristics and poor mechanical properties limit its wider application. How to use the method of biomimetic synthesis to realize the rapid and effective mineralization of type I collagen fibe...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/02A61L27/12A61L27/16A61L27/18A61L27/54
Inventor 焦凯牛丽娜陈吉华郑智明李齐宏
Owner 博纳格科技(天津)有限公司
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