Traditional Chinese medicine external suppository for treating women morbid leucorrhea and preparation method thereof
A technology of suppository and traditional Chinese medicine, which is applied in the field of external Chinese medicine suppository for women's leukorrhagia and its preparation, which can solve problems affecting work and quality of life, repeated attacks of patients, and affecting quality of life, etc., and achieves convenient administration and endometrial repair. Effect of improving and relieving pain
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[0047] Preparation method 1 of the suppository of the present invention: Take 1500g of Angelica dahurica, 1500g of myrrh, 1500g of Atractylodes atractylodes and 1500g of notopterygium, vaporize them into crystals by distillation, crush them, pass through a 100-120 mesh sieve, and make them into fine powder for later use. Add 1500g of Smilax tuckahoe, 1500g of plantago seed, 1500g of salvia miltiorrhiza, 1500g of baicalensis, 1500g of forsythia, 1500g of Hedyotis diffusa, 1500g of cnidium, 1500g of Cortex Phellodendri, 1500g of Sophora flavescens, 1500g of Radix 1500g, intermittent 1500g of Radix Paeoniae Rubra, 1500g was cut into coarse grains, then soaked in ethanol for 2 hours. Then heat and extract twice, each time for 1-2 hours, combine the extracts, remove the supernatant after standing still, then filter through 100-120 mesh, and then ultrafilter through an ultrafiltration column with a cut-off molecular weight of 5000-10000. Concentrate the extract with a relative densi...
Embodiment 3
[0069] Embodiment 3: Vaginal mucosa irritation test result
[0070] 1. Test method:
[0071] After 3 days of experimental animal quarantine, select 18 above-mentioned healthy rabbits for use, and be randomly divided into three groups, each group of 6, respectively: blank control, excipient control, suppository group of the present invention (5 times concentration by application solution). Sterilized tampons of appropriate size soaked in sterilized physiological saline and the test substance were placed in the vagina of the animals in the vehicle control group and the test substance group, and were in contact with the vaginal mucosa for 6 hours, and the animals were sacrificed 24 hours later. The local vaginal tissue was taken out and the lesion was observed.
[0072] 2. Test results: vaginal mucosa irritation test results
[0073]
[0074]
Embodiment 4
[0075] Embodiment 4: skin allergy test result
[0076] Use the suppository of the present invention to carry out induction and excitation contact tests, observe the test mice after 24 hours and 48 hours, and there is no phenomenon such as erythema and edema in the skin, and there is no difference with the negative control group. The results show that the suppository has close to zero skin reaction intensity, that is, no skin allergy.
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