Lincomycin hydrochloride breast injectant for dairy cow and preparation method thereof

Abstract

The invention discloses a lincomycin hydrochloride breast injectant for a dairy cow and a preparation method thereof. The lincomycin hydrochloride breast injectant for the dairy cow is composed of lincomycin hydrochloride, a suspending agent, a surface active agent, an antioxidant, a preservative and soybean oil for injection, wherein the lincomycin hydrochloride is taken as an active ingredient; under the condition of the antibacterial effect of the medicine is guaranteed, the surface active agent and the suspending agent are added for realizing a synergistic effect, so that pharmaceutical ingredients are uniformly dispersed, the beneficial effects of high consistency, good stability and biocompatibility, long acting time and obvious sustained release effect are achieved. The prepared breast injectant has the advantages that a colloid mill is adopted for grinding a part of materials, then a high-speed shearing and emulsifying machine is used for emulsifying and dispersing; oil suspension obtained by the combined use of the colloid mill and the high-speed shearing and emulsifying machine has the advantages of smaller particle size, higher uniformity and shorter grinding time when compared with oil suspension obtained by only adopting a stirring machine or a colloid mill in the traditional method; in addition, release amount of active ingredients and bioavailability are effectively increased, and the prepared breast injectant has a good treatment effect on a diary cow infected with diseases after delivery. The preparation method of the breast injectant is simple and the breast injectant is low in cost, so that the breast injectant is applicable to large-scale industrial production.

Description

technical field [0001] The invention relates to a lincomycin hydrochloride udder injection for dairy cows and a preparation method thereof, belonging to the technical field of veterinary drug preparations. Background technique [0002] Lincomycin (lincomycin) is a lincosamine antibiotic, which has a strong antibacterial effect on most anaerobic bacteria and Gram-negative bacteria. Lincomycin acts on the 50S subunit of the ribosome of susceptible bacteria to prevent the elongation of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. Lincomycin is generally a bacteriostatic agent, but at high concentrations, it also has a bactericidal effect on highly sensitive bacteria. [0003] Most of the existing lincomycin hydrochloride are capsules, powders or water injections, which have low stability, biocompatibility and release of active ingredients, and cannot be injected directly through the udder, and are not targeted for the treatment of postpartum ...

AI Technical Summary

Problems solved by technology

[0003] Most of the existing lincomycin hydrochloride are capsules, powders or water injections, which have low stability, biocompatibility and release of active ingredients, and cannot be injected directly through the udder, and are not targeted for the treatment of postpartum infection in dairy cows. Moreover, the existing commercially available lincomycin hydrochloride udder injection for dairy cows adopts traditional raw materials to be mixed to make a sol, and then grinds with a colloid mill or a high-pressure homogenizer to make an oil suspension, which has poor stability and biocompatibility. Poor resistance, low content of active ingredients, unsatisfactory therapeutic effect

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