Preparation method for TPGS medicine carrying lipidosome-natural material composite nano-fiber bracket
A technology of composite nanofibers and natural materials, which is applied in the field of drug-loaded liposomes composited with natural material nanofiber scaffolds, can solve the problems of limiting clinical application and industrial production, low drug loading rate, thermodynamic instability, etc., and achieve drug loading And the effects of high transfection efficiency, good biocompatibility, and good application prospects
Inactive Publication Date: 2015-03-04
DONGHUA UNIV
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Abstract
The invention provides a preparation method for a TPGS medicine carrying lipidosome-natural material composite nano-fiber bracket. The preparation method comprises the following three steps: step 1: adopting a thin film dispersing method to prepare the medicine carrying lipidosome decorated by polyethyleneglycol Vitamin E succinic acid ester TPGS; step 2: preparing aqueous solution containing a natural material; adding the aqueous solution in the medicine carrying lipidosome suspension decorated by the TPGS; sealing and stirring until the solution is transparent to obtain mixed spinning solution; step 3: conducting static spinning by adopting the mixed spinning solution prepared in the step 2 to obtain the natural material composite nano-fiber bracket loading the medicine carrying lipidosome decorated by TPGS. The composite nano-fiber bracket has favorable biocompatibility, and is high in medicine loading capacity and transfection efficiency; the preparation method is simple, and mild in reaction conditions; the composite nano-fiber bracket has unique advantages when the bracket is used as a medicine slow release carrier and a tissue engineering scaffold, and has broad application prospect in the field of biomedicine.
Application Domain
Prosthesis
Technology Topic
ElectrospinningChemistry +9
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