Regenerated silk fibroin gel mask and preparation method thereof

A technology for regenerating silk fibroin and gel film, applied in the field of transparent silk fibroin gel film and its preparation, can solve the problems affecting the application prospect of silk fibroin gel, poor physical and mechanical properties, etc. The effect of compatibility, excellent stability, excellent mechanical properties

Active Publication Date: 2015-03-25
苏州盛泽科技创业园发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this gel material is white and opaque, the interior is mainly porous, and its physical and mechanical properties are very poor, similar to "tofu dregs". These properties affect the application prospects of silk fibroin gel

Method used

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  • Regenerated silk fibroin gel mask and preparation method thereof
  • Regenerated silk fibroin gel mask and preparation method thereof
  • Regenerated silk fibroin gel mask and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Natural mulberry silk was boiled with 0.5wt% sodium bicarbonate solution for 60 minutes to obtain degummed mulberry silk;

[0040] (2) Dissolve the degummed silk in step (1) in 8% ZnCl at a concentration of 10wt% 2 In -90% formic acid, the dissolution temperature is 25°C, and the dissolution time is 3 hours to obtain a silk fibroin solution. After drying at a temperature of 20°C and a relative humidity of 65%, a CaCl-containing solution is obtained. 2 silk fibroin film;

[0041] (3) the CaCl obtained in step (2) 2 The silk fibroin film is soaked in running water and rinsed for 5 hours to obtain a regenerated silk fibroin gel film with a water content of about 65%.

Embodiment 2

[0043] (1) Natural tussah silk was degummed by boiling 0.5wt% sodium carbonate solution for 30 minutes, and the degummed tussah silk was obtained after repeating 3 times;

[0044] (2) Dissolve the degummed silk in step (1) in 4% CaCl at a concentration of 8wt% 2 In -88% formic acid, the dissolution temperature is 35°C, and the dissolution time is 4h to obtain a silk fibroin solution. After drying at a temperature of 30°C and a relative humidity of 60%, a CaCl-containing solution is obtained. 2 silk fibroin film;

[0045] (3) the CaCl obtained in step (2) 2The silk fibroin film was immersed in 25% ethanol aqueous solution for 10 hours, and the liquid was changed every half hour, and then washed in running water for 3 hours to obtain a regenerated tussah silk fibroin gel film with a water content of about 60%.

Embodiment 3

[0047] (1) Natural mulberry silk was degummed by boiling with 0.25wt% sodium bicarbonate solution for 30 minutes, and repeated 3 times to obtain degummed mulberry silk;

[0048] (2) Dissolve the degummed silk in step (1) in 4% MgCl at a concentration of 8wt% 2 In -98% formic acid, the dissolution temperature is 35°C, and the dissolution time is 1h to obtain a silk fibroin solution. After drying at a temperature of 30°C and a relative humidity of 40%, a CaCl-containing solution is obtained. 2 silk fibroin film;

[0049] (3) the MgCl obtained in step (2) 2 The silk fibroin film was soaked in running water and rinsed for 5 hours to obtain a regenerated silk fibroin gel film with a water content of about 55%.

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Abstract

The invention discloses a regenerated silk fibroin gel mask and a preparation method thereof. The specific preparation method comprises the following steps: (1) directly dissolving degummed silk into a formic acid solution containing salt, and drying to obtain a silk fibroin mask containing salt; and (2) directly soaking the dried mask into an alcoholic solution or water, so as to prepare the regenerated silk fibroin gel mask. Compared with the prior art, the gel mask has the advantages of traditional silk fibroin mask and hydrogel, is transparent, excellent in mechanical property and high in moisture content, and simultaneously has a biomimetic nanometer fiber structure, good degradability and good biocompatibility; and in addition, the gel mask is simple in preparation method, short in flow and easy to achieve mass production. The gel mask has excellent physical and chemical properties and biological characteristics, so that the regenerated silk fibroin gel mask has a wide application prospect in the fields of cosmetics and regenerative medicines, such as masks, skin dressing, dura mater cerebralis, corneas, anti-adhesive films, nerve sheath pipes and the like.

Description

technical field [0001] The invention relates to a silk fibroin gel material and a preparation method thereof, in particular to a transparent silk fibroin gel film and a preparation method thereof. The method is simple and efficient and can be widely used in the fields of biology and medicine. Background technique [0002] my country is the main producer of silk, and its silk output accounts for more than 70% of the world's output. In recent years, the research and application of silk has extended from the traditional textile field to high-tech fields, such as optoelectronics and biomedical materials, especially as biomedical materials have made important progress. Silk fibroin is obtained by degumming silk. It is a natural structural protein without physiological activity. It is mainly composed of three simple amino acids: glycine, alanine and serine, which account for about 85% of the total protein. The degummed silk has good biocompatibility and mechanical properties, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/42A61L27/22A61L27/52A61L31/04A61L31/14A61K47/42A61K8/64
CPCA61K8/64A61K9/0002A61K47/42A61L15/32A61L15/42A61L15/62A61L26/0047A61L26/0061A61L27/227A61L27/50A61L27/52A61L31/047A61L31/14A61L31/145A61L2430/16A61L2430/32C08L89/00
Inventor 张锋别诗宇周燕左保齐
Owner 苏州盛泽科技创业园发展有限公司
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