Continuous-chromatography separating and purifying method of etimicin sulfate

A technology of etimicin sulfate and continuous chromatography, which is applied in the field of separation and purification of antibacterial drug etimicin, can solve the problems of large consumption of water and eluent, low purity of etilmicin, and high environmental protection pressure, and achieves High resin utilization rate, optimized purity and yield, and improved productivity

Inactive Publication Date: 2015-03-25
WUXI JIYU SHANHE PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The etimicin separated by this traditional separation method has many disadvantages such as low purity, low production yield, large consumption of water and eluent, long cycle time, and high environmental protection pressure.

Method used

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  • Continuous-chromatography separating and purifying method of etimicin sulfate
  • Continuous-chromatography separating and purifying method of etimicin sulfate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Combine below figure 1 And the embodiment is described in detail:

[0048] The selected resin of the present invention is No. 1 resin of Huazhen chromatography, and the resin particle diameter is more than 95% of 100 orders, and the filling capacity of each resin column is 0.08m 3 , the capacity of the resin column is 0.1m 3 , the actual filling ratio is 80%. The total size of the system is 3m×3m×5m (length×width×height).

[0049] The disc transfer type continuous chromatographic separation system separates etimicin into the following areas:

[0050] 1) Adsorption area: (Unit 25)

[0051] There is one unit (unit 25) in this area. Through flow rate control, the raw materials first enter unit 25, and then enter unit 27 in series for cleaning.

[0052] 2) Laundry area: (Units 24, 26-30)

[0053]After adsorption, each resin needs to be washed with water, located before and after the adsorption area. After the resin column rotates to the adsorption washing area, the m...

Embodiment 2

[0068] Combine below figure 1 And the embodiment is described in detail:

[0069] The selected resin of the present invention is YPR-II resin, and the resin is 80 mesh, and the filling capacity of each resin column is 0.08m 3 , the capacity of the resin column is 0.1m 3 , the actual filling ratio is 80%. The total size of the system is about 3m×3m×5m (length×width×height).

[0070] The simulated moving bed continuous chromatographic separation system separates etimicin into the following areas:

[0071] 1) Adsorption area: (Unit 25)

[0072] There is one unit (unit 25) in this area. Through flow rate control, the raw materials first enter unit 25, and then enter unit 27 in series for cleaning.

[0073] 2) Laundry area: (Units 24, 26-30)

[0074] After adsorption, each resin needs to be washed with water, located before and after the adsorption area. After the resin column rotates to the adsorption washing area, the material liquid (mainly clarified liquid) entrained in ...

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Abstract

The invention relates to a continuous-chromatography separating and purifying method of etimicin sulfate. Efficient separation of the etimicin is realized by virtue of a continuous-chromatography process. The continuous-chromatography separating and purifying method of etimicin sulfate comprises the following steps: introducing hydrolysate of the synthesized etimicin into a continuous-chromatography system, performing adsorption, impurity washing and elution on the etimicin, collecting eluant, performing chromatographic column regeneration, concentrating the collected eluant, and salifying and discoloring the concentrated eluant to obtain the etimicin sulfate. The etimicin sulfate separated by the method disclosed by the invention is high in yield, high in purity, low in cost, environmentally friendly and suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of chemical pharmacy, in particular to a method for separating and purifying antibacterial drug etimicin. Background technique [0002] The structural formula of Etimicin sulfate (Etimicin sulfate) is as follows: [0003] [0004] It is a semi-synthetic aminoglycoside antibiotic and the only anti-infective drug that has obtained the national first-class new drug certificate. This product is suitable for sensitive Escherichia coli, Klebsiella pneumoniae, Serratia spp., A. citrate, Enterobacter spp., Acinetobacter spp., Proteus spp., Haemophilus influenzae, aeruginosa Various infections caused by Pseudomonas and Staphylococci etc. Clinical studies have shown that this product has a good effect on the following infections: Respiratory tract infections: such as acute bronchitis, acute exacerbation of chronic bronchitis, community lung infection, etc. Kidney and genitourinary system infections: such as acute nephriti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/236C07H1/06
CPCY02P20/582C07H15/236C07H1/06
Inventor 薛超一
Owner WUXI JIYU SHANHE PHARM CO LTD
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