A kind of preparation method of 3-methyl-4-oxo-4-(p-amino)phenylbutyric acid

A technology of phenylbutyric acid and p-amino group is applied in the field of preparation of 3-methyl-4-oxo-4-(p-amino)phenylbutyric acid, and can solve the problems of high cost of elimination, complicated post-treatment process, The problem of high cost of raw materials, to achieve the effect of safe and simple operation, novel process design, and environmentally friendly reaction conditions
CN104496834BActive Publication Date: 2016-05-11ASTATECH CHENGDU BIOPHARM CORP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ASTATECH CHENGDU BIOPHARM CORP
Publication Date
2016-05-11

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Abstract

The invention discloses a preparation method of a levosimendan key intermediate 3-methyl-4-oxo-4-(p-amino)phenylbutyric acid, which comprises six reaction steps disclosed in the specification. The method has the advantages of novel technological design, accessible raw materials, environment-friendly reaction conditions, no need of virulent chemicals, high yield of each reaction step, high total yield and safe and simple operation, and is suitable for industrial production.
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Description

technical field

[0001] The invention relates to a preparation method of an intermediate of levosimendan, a medicine for enhancing myocardial contractility, and in particular to a preparation method of 3-methyl-4-oxo-4-(p-amino)phenylbutyric acid. Background technique

[0002] Levosimendan is a calcium sensitizer drug for enhancing myocardial contractility developed by Orion, Finland, and is the first drug of this type to be marketed. First launched in Sweden in October 2000, it is used to treat various acute and refractory heart failure diseases.

[0003]

[0004] The mechanism of action of levosimendan is mainly by increasing the sensitivity of cardiac contractile proteins to calcium ions and opening the ATPase-sensitive potassium ion channels on the cell membrane, increasing the myocardial contractility while dilating peripheral blood vessels and coronary arteries, and reducing the anterior and posterior cardiac tension. The load can quickly improve the symptoms of pat...

Claims

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