Near-infrared silver-indium-selenium quantum dot and preparation method thereof

Abstract

The invention discloses a near-infrared silver-indium-selenium quantum dot and a preparation method thereof. The preparation method comprises the following steps: (1) dissolving cupric chloride or silver acetate, indium acetate, sodium hydrogen selenide and 3-mercaptopropionic acid according to the molar ratio of 1:1-5:10-20:34-36, so as to obtain a mixed solution, wherein the concentration of cupric chloride or silver acetate is 0.7-0.9 mmol / L; and (2) adjusting the pH value of the mixed solution obtained in the step (1) to 8-9, then heating the mixed solution at 93-98 DEG C for reaction for 55-65 min, and cooling to room temperature, so as to obtain the near-infrared silver-indium-selenium quantum dot. The prepared quantum dot has the advantages of being nontoxic, simple in method, mild and controllable in reaction conditions, short in reaction time, good in reappearance and the like. The prepared quantum dot is widely applicable to cell and tissue imaging as a fluorescent marker, and also is applicable to in vivo imaging research.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a near-infrared silver indium selenium quantum dot and a preparation method thereof. Background technique [0002] Quantum dots (quantumdots, QDs), also known as semiconductor nanocrystals, are nanocrystals composed of II-IV or III-V elements. Quantum dots have attracted much attention due to their excellent physical and chemical properties, such as quantum size effect, luminescent properties, and chemical processability, as well as their applications in biomarkers, biosensing, optoelectronics, and solar cells. [0003] Compared with traditional organic fluorescent reagents, quantum dots have many excellent spectral properties, showing broad application prospects in the fields of biology and medicine, especially the near-infrared fluorescent quantum dots developed in recent years, due to their strong Penetrating power, especially suitable for in vivo non-invasive visualiza...

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Problems solved by technology

It has been reported in the literature that silver sulfide quantum dots were prepared by a high-temperature organic method. Due to the high-temperature oil-phase method, the obtained quantum dots are oil-soluble and require further modification before they can be applied to biological systems; water-soluble near-infrared cadmium telluride was prepared by microwave radiation. Quantum dots, the acquisition of tellurium sources requires a long reaction time and the reaction requires an oxygen-free environment. At the same time, cadmium elements contain high toxicity; a manganese-doped zinc selenide quantum dot that emits yellow visible light was synthesized by an aqueous phase method point, but the adjustable wavelength is limited, which is not conducive to in vivo imaging research

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