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Modified polyvinyl alcohol hydrogel material, special die, preparation method and application

A technology of polyvinyl alcohol and polyvinyl alcohol solution, which is applied in the fields of medical science and prostheses, can solve problems such as interface problems between multilayer materials, inappropriate pore structure, and low pore connectivity, so as to enhance biological activity and enhance Mechanical properties, growth-promoting effect

Inactive Publication Date: 2015-06-17
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] One of the purposes of the present invention is to overcome the shortcomings of the prior art such as inappropriate pore structure, low pore connectivity and interface problems between multilayer materials, and provide a modified polyvinyl alcohol hydrogel with a dense / porous layered bionic structure. Glue cartilage / bone repair material, and also provide the preparation method of the material

Method used

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  • Modified polyvinyl alcohol hydrogel material, special die, preparation method and application
  • Modified polyvinyl alcohol hydrogel material, special die, preparation method and application
  • Modified polyvinyl alcohol hydrogel material, special die, preparation method and application

Examples

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Effect test

Embodiment 1

[0043] A special mold for preparing modified polyvinyl alcohol hydrogel material, the cavity is provided with a filter 3, the filter 3 divides the cavity into upper and lower cavities, the bottom of the lower cavity is provided with an air outlet 4, and the upper cavity The body is equipped with a soluble porogen 2, and a liquid storage cavity 1 is reserved on the top of the porogen 2.

[0044] A kind of preparation for preparing modified polyvinyl alcohol hydrogel material comprises the steps:

[0045] Step 1, preparation of polyvinyl alcohol solution and polyvinyl alcohol / polyoxymethylene blended suspension

[0046] Preparation method: prepare a solution of polyvinyl alcohol and 80% DMSO solution with a mass ratio of 15:85, and stir at 110°C for 3 hours to obtain a polyvinyl alcohol solution.

[0047] Prepare a solution of polyvinyl alcohol, 80% DMSO solution and polyoxymethylene in a mass ratio of 15:85:15, and stir at 110° C. for 3 hours to obtain a polyvinyl alcohol / poly...

Embodiment 2

[0061] Step 1, preparation of polyvinyl alcohol solution and polyvinyl alcohol / nylon 6 blended suspension

[0062] Preparation method: Prepare a solution with a mass ratio of polyvinyl alcohol to aqueous solution of 15:85, and stir at 98°C for 8 hours to obtain a polyvinyl alcohol solution.

[0063] A solution of polyvinyl alcohol, 80% DMSO solution, and nylon 6 with a mass ratio of 15:85:15 was prepared, and stirred at 110° C. for 3 hours to obtain a polyvinyl alcohol / nylon 6 blended suspension.

[0064] Step 2. Dispersion of micro-nano hydroxyapatite powder

[0065] Disperse micro-nano hydroxyapatite in deionized water, put it into an ultrasonic disperser, and disperse ultrasonically for 30 minutes, then inject it into the prepared polyvinyl alcohol solution, and continue stirring.

[0066] Step 3, Bubble Treatment of Blended Suspension

[0067] Put the blended suspension of polyvinyl alcohol / hydroxyapatite dissolved in step 2 under nitrogen protection at 95°C for 5 hours,...

Embodiment 3

[0077] Step 1, preparation of polyvinyl alcohol solution and polyvinyl alcohol / polyether ether ketone blended suspension

[0078] Preparation method: prepare a solution of polyvinyl alcohol and 80% DMSO solution with a mass ratio of 15:85, and stir at 100°C for 5 hours to obtain a polyvinyl alcohol solution.

[0079] A solution of polyvinyl alcohol, 80% DMSO solution and polyether ether ketone with a mass ratio of 15:85:15 was prepared, and stirred at 110° C. for 3 hours to obtain a polyvinyl alcohol / polyether ether ketone blended suspension.

[0080] Step 2. Dispersion of micro-nano bioactive glass powder

[0081] Disperse micro-nano bioactive glass in 80% DMSO solution, put it into an ultrasonic disperser, ultrasonically disperse for 30 minutes, then inject it into the prepared polyvinyl alcohol solution, and continue stirring.

[0082] Step 3, Bubble Treatment of Blended Suspension

[0083] Put the blended suspension of polyvinyl alcohol / bioactive glass dissolved in step ...

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Abstract

The invention discloses a modified polyvinyl alcohol hydrogel material, a special die, a preparation method and application. The preparation method comprises the following steps: (1) preparing polyvinyl alcohol / bioactive calcium-phosphorus powder blended suspension I and polyvinyl alcohol / engineering plastic blended suspension II; (2) injecting the suspension I into the special die, vacuumizing at the gas outlet of the die until a pore-forming agent is right impregnated by the suspension I, adding the suspension II, and pressurizing the die to obtain a target material precursor I; (3) performing freezing treatment on the precursor I, performing unfreezing treatment at room temperature, and radiating with gamma rays to further form a target material precursor II; (4) dialyzing and washing the precursor II in de-ionized water for multiple times to obtain the target material. The obtained material has high biocompatibility and bioactivity, and can be applied to cartilage repair and replacement, the problem that an interface exists between a compacted layer and a porous layer is solved, and the problems of stress concentration and the like in a using process are solved.

Description

technical field [0001] The invention relates to a modified polyvinyl alcohol hydrogel cartilage / bone repair material with a dense / porous layered bionic structure and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Polyvinyl alcohol (polyvinyl alcohol, PVA for short) is a kind of water-soluble polymer obtained by partial or complete hydrolysis of polyvinyl acetate. The chemical composition and unique three-dimensional structure of polyvinyl alcohol hydrogel make it have unique physical and biological properties, such as good swelling, high water content, good viscoelasticity, softness and good biocompatibility etc., making it very close to human tissue, so it is widely used in the field of biomedical materials, in wound dressings, eye contact lenses, tissue engineering scaffolds, artificial skin, drug sustained release, biosensors, artificial articular cartilage and meniscus replacement etc. have been widely used. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C33/00B29C67/20B29C67/24C08L29/04C08L59/00C08L77/02C08L71/12C08L61/16C08K3/32C08J9/26C08J9/08C08J3/28C08J3/075A61L27/46A61L27/52A61L27/56A61L27/54
Inventor 任力王迎军肖凤财刘卅卢建熙王臻褚明磊
Owner SOUTH CHINA UNIV OF TECH
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