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Composite particle for Raman spectrum detection of analyte, its preparation method and use method

A technology of Raman spectrum detection and composite particles, which is applied in the field of Raman spectrum detection of substances, can solve the problems of weakened SERS enhancement effect, reduced SERS activity, and only one-time use, so as to enhance the detection effect of Raman spectrum and improve Effect of SERS activity and reduction of detection cost

Active Publication Date: 2018-09-11
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the above-mentioned metal core-shell nanoparticles have the same disadvantages as the traditional SERS substrate composed of noble metal nanoparticles: (1) usually only one-time use, difficult to recycle, resulting in waste of resources; (2) due to surface plasmon resonance The resulting SERS effect will decrease exponentially with the increase of the distance between particles, so the SERS activity of metal nanoparticles decreases after coating the inert shell; (3) When the metal core-shell nanoparticles are dispersed in the solution, the metal nanoparticles The distance between particles will become larger, resulting in weakened SERS enhancement effect, so the SHINERS technology is not suitable for in-situ detection of liquid systems

Method used

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  • Composite particle for Raman spectrum detection of analyte, its preparation method and use method
  • Composite particle for Raman spectrum detection of analyte, its preparation method and use method
  • Composite particle for Raman spectrum detection of analyte, its preparation method and use method

Examples

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Embodiment 1

[0041] A composite particle used for Raman spectroscopy detection is made of magnetic particles Fe 3 O 4 / C and core-shell nano-ion Ag / C, the Ag / C particles are attached to Fe 3 O 4 / C particle surface; the Ag / C particle has a core-shell structure, with Ag nanoparticles as the core, and the core is covered with a dense C shell.

[0042] Above Fe 3 O 4 The preparation method of / C-Ag / C composite particles is as follows:

[0043] (1) Fe 3 O 4 / C Preparation of magnetic particles

[0044] Disperse 0.3 g of ferrocene in 30 mL of acetone, add 3 mL of hydrogen peroxide dropwise after sonicating for 30 minutes, and then place it in a 50 mL reactor and react at 210° C. for 48 hours to obtain a black magnetic substance. After the reaction, the obtained magnetic particles were washed with acetone and absolute ethanol, collected by magnet, and finally put into a vacuum drying oven to dry, to obtain Fe 3 O 4 / C Magnetic particles.

[0045] (2) Preparation of Ag / C core-shell nano-ion aqueous solut...

Embodiment 2

[0058] In this embodiment, the composite particle Fe used for Raman spectroscopy detection 3 O 4 The composition structure of / C-Ag / C is the same as that in Example 1, and the preparation method is the same as that in the Example, that is, Fe is first prepared. 3 O 4 / C magnetic particles, and then prepare an aqueous solution of Ag / C core-shell nanoparticles, and finally attach the Ag / C core-shell nanoparticles to Fe 3 O 4 / C Magnetic particle surface.

[0059] Use the Fe 3 O 4 / C-Ag / C composite particle enhanced Raman spectroscopy to detect 4-mercaptopyridine in situ on the surface of silicon wafer, the specific detection method is as follows:

[0060] Add 100 μL of this Fe 3 O 4 / C-Ag / C composite particle aqueous solution and 900μL1.0×10 -5 M4-Mercaptopyridine solution is mixed, and then 30μL of the mixed solution is dropped on the silicon wafer, and the Raman test is performed after natural drying. The test result is as follows Figure 7 As shown in curve a, that is, adding Fe 3 O...

Embodiment 3

[0066] In this embodiment, the composite particle Fe used for Raman spectroscopy detection 3 O 4 The composition structure of / C-Ag / C is the same as that in Example 1, and the preparation method is the same as that in the Example, that is, Fe is first prepared. 3 O 4 / C magnetic particles, and then prepare an aqueous solution of Ag / C core-shell nano ions, and finally attach Ag / C core-shell nano ions to Fe 3 O 4 / C Magnetic particle surface.

[0067] Use the Fe 3 O 4 / C-Ag / C composite particle enhanced Raman spectroscopy in situ detection of acetonitrile in ethanol solution, the specific detection method is as follows:

[0068] Take two parts of Fe 3 O 4 / C-Ag / C composite particle aqueous solution, each is 100μL, one part is mixed with 900μL pure acetonitrile to get an acetonitrile / water mixed solution; the other part is mixed with 800μL ethanol and 100μL acetonitrile to get acetonitrile / water / Ethanol mixed solution; the mixed solution is injected into the sample cell separately, an...

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Abstract

The invention provides composite particles for Raman spectroscopy detection of to-be-detected substance. The composite particles are composed of magnetic particles and metal core-shell nanoparticles, wherein the metal core-shell nanoparticles are attached to the surface of the magnetic particles and each have an inert outer shell. The composite particles have high SERS activity, can be used for in-situ Raman detection in a solution and can be used repeatedly, so that the composite particles have good application value in substance Raman spectroscopy detection and can effectively broaden the application scope of the surface enhanced Raman scattering technology.

Description

Technical field [0001] The invention relates to a Raman spectroscopy detection technology for substances, in particular to a composite particle used for Raman spectroscopy detection of a analyte, a preparation method and a use method thereof. Background technique [0002] Surface enhanced Raman spectroscopy (SERS), as a vibrational spectroscopy technology, can not only give detailed structural information of the detected object, but also has extremely high detection sensitivity, sometimes even reaching the single-molecule level of detection. There are broad application prospects in the fields of surface science, analytical science and biological science. However, the SERS effect only appears on rough coin family metal surfaces, such as gold, silver, copper, and a few transition metals, which limits its application to various substances, materials, and various smooth and even single crystal surfaces. [0003] The discovery of Tip enhanced Raman spectroscopy (TERS) solved the proble...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65
Inventor 何茹程昱川许高杰蒋萌靳婷罗玉霞
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI