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Oral pharmaceutical composition of diacerein and berberine

A technology of diacetyl rhein and a composition is applied in the field of compound preparation and preparation of berberine and diacetyl rhein, can solve problems such as lack of therapeutic drugs, and achieves simple preparation method, good stability and simple product prescription. Effect

Inactive Publication Date: 2015-07-15
蒋鸣昱
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is still a lack of effective therapeutic drugs for diabetic nephropathy

Method used

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  • Oral pharmaceutical composition of diacerein and berberine
  • Oral pharmaceutical composition of diacerein and berberine
  • Oral pharmaceutical composition of diacerein and berberine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The prescription of ordinary tablets (1000 tablets) is shown in Table 1:

[0047] Table 1 Prescription of ordinary tablets (1000 tablets) (the following weight unit is g)

[0048]

[0049]

[0050] Preparation Process:

[0051] (1) Premixing active pharmaceutical ingredients, fillers and binders or ethanol solution and wet granulation;

[0052] (2) drying and sizing the granules prepared by wet granulation to obtain dry granules;

[0053] (3) blending dry granules with disintegrating agent and lubricant to obtain blended granules;

[0054] (4) compressing the mixed granules into tablets to obtain plain tablets;

[0055] (5) Carry out common film coating to plain tablet coating material;

[0056] Wet granulation can use wet granulator, parameters: 1 stirring, 2 shearing, a total of 4min ~ 8min.

[0057] Granules are dried using a box-type drying oven or a fluidized granulation dryer at a drying temperature of 50°C to 70°C.

[0058] The final mixing adopts th...

Embodiment 2

[0079] The prescription of capsules (1000) is shown in Table 8:

[0080] The prescription of table 8 capsule (1000) (the following weight unit is g)

[0081]

[0082] Preparation Process:

[0083] (1) Premixing active pharmaceutical ingredients, fillers and binders or ethanol solution and wet granulation;

[0084] (2) drying and sizing the granules prepared by wet granulation to obtain dry granules;

[0085] (3) blending dry granules with lubricant to obtain blended granules;

[0086] (4) Capsule filling of the blended granules.

[0087] Wet granulation can use wet granulator, parameters: 1 stirring, 2 shearing, a total of 4min ~ 8min.

[0088] Granules are dried using a box-type drying oven or a fluidized granulation dryer at a drying temperature of 50°C to 70°C.

[0089] The final mixing adopts three-dimensional motion mixer or lifting hopper mixer.

[0090] Capsule filling uses a capsule filling machine.

[0091] The prescription detection conclusion of capsule (...

Embodiment 3

[0106] Streptococcus (STZ) is a kind of widely used medicine that causes rat diabetes model, male Wistar rat body weight 180-220g, single intraperitoneal injection is dissolved in the STZ of pH=4.5 sodium citrate (27.5mg / mL ), calculated as 55mg / kg based on body weight. The control group was injected with the same volume of solvent sodium proxylate (0.2mL / 100g). Three days after the injection, blood was taken from the tail vein to measure blood sugar. Rats with blood glucose greater than or equal to 16.7mmol / L were selected as experimental rats. The screened rats were divided into groups and oral administration was started. Urine was collected for 12 hours (21:00-9:00) every two weeks from the injection of STZ in rat metabolic cages and the urine protein content was determined. After fasting at 21:00 the night before for days 0, 4, 8, and 12, blood was taken from the tail vein at 9:00 the next morning to measure the blood sugar concentration. After the rats in each group we...

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Abstract

The invention relates to the field of compound medical preparations, and especially relates to applications of a compound preparation of diacerein and berberine in the medicine field. The invention discloses an oral pharmaceutical composition, which is composed of pharmaceutical active components and pharmaceutical auxiliary materials; wherein the pharmaceutical active components are composed of berberine / pharmaceutically-acceptable salts of berberine and diacerein / pharmaceutically-acceptable salts of diacerein, and the pharmaceutically-acceptable salts can be hydrochloride or sulfate. The pharmaceutical composition can be made into common tablets, dual-layer tablets, enteric coated tablets, capsules, particles, and powder. The pharmaceutical composition can reduce the blood sugar and blood fat, and prevent / treat diabetic complication, especially diabetic nephropathy.

Description

technical field [0001] The invention relates to the field of compound pharmaceutical preparations, in particular to a compound preparation of berberine and diacetylrhein and a preparation method thereof. Background technique [0002] Berberine, also known as berberine, is an alkaloid extracted from plants such as Cortex Phellodendron, Coptidis Rhizoma, and Three Needles, and can also be synthesized artificially. At first, berberine tablets were mainly used for intestinal infections such as gastroenteritis and bacterial venereal diseases caused by sensitive pathogenic bacteria. The pharmacodynamics of the drug is that it has a broad antibacterial spectrum, and it has inhibitory effects on a variety of Gram-positive and Gram-negative bacteria in vitro, including hemolytic streptococcus, Staphylococcus aureus, Vibrio cholerae, meningococcus, typhoid Bacillus, diphtheria, etc. have a strong inhibitory effect. The mechanism of action is that microcarpine can reduce the number o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P3/10A61P3/06A61P13/12A61K31/222
Inventor 朱孝云吴亚雯蒋鸣昱
Owner 蒋鸣昱
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