Agarose microsphere-containing cross-linked sodium hyaluronate gel for injection and preparation method thereof

Abstract

The invention discloses agarose microsphere-containing cross-linked sodium hyaluronate gel for injection and a preparation method thereof. The preparation method comprises the following steps of 1, adding agarose microspheres into injection water, carrying out stirring, adding injection-level sodium hyaluronate powder into the mixed solution, and carrying out stirring until complete swelling, 2, adding a sodium hydroxide solution and 1,2,7,8-diepoxyoctane into the solution obtained by the step 1, and carrying out stirring under control of a sodium hydroxide concentration, 3, heating the mixture to obtain water-containing gel, 4, cutting the water-containing gel into small pieces and carrying out washing, 5, sieving the washed gel pieces, draining water in the gel pieces and adding a stroke-physiological saline solution into the gel pieces for balance, and 6, carrying out centrifugation and disinfection to obtain the agarose microsphere-containing cross-linked sodium hyaluronate gel finished product. The agarose microsphere-containing cross-linked sodium hyaluronate gel utilizes medical sodium hyaluronate, medical agarose microspheres, endotoxin, other proteins and exogenous DNA, and has indexes satisfying national and industry relevant standards. Through use of the agarose microspheres, the gel has a substantially slow resolving rate after injection and is an ideal injection filling product.

Description

technical field [0001] The invention belongs to the technical fields of medical cosmetology and biomedicine, and in particular relates to a cross-linked sodium hyaluronate gel containing agarose microspheres for subcutaneous and dermal injection and a preparation method thereof. Background technique [0002] Injection cosmetology is a kind of non-surgical plastic surgery. It uses injection method to inject biomaterials or synthetic materials with good biocompatibility into the dermis or subcutaneous layer, and achieves the purpose of reducing skin wrinkles or shaping through different mechanisms. A method of plastic surgery. Sodium hyaluronate is a polysaccharide biomaterial with very good biocompatibility. The degradation and metabolism process in the body has been studied clearly and is safe for the human body. It is the first choice for the preparation of gel products. Nowadays, gel products are well known to the public as an important product in the field of micro-plast...

AI Technical Summary

Problems solved by technology

However, the current sol products have the following defects: 1. The cost of use by consumers is relatively high, and the cost of each injection can be thousands or even tens of thousands of yuan

2. Hyaluronic acid gel basically completes the degradation and absorption in about 6 months in the body, and consumers have to re-inject, which increases the burden on consumers

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