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Absorbable medical suture line and preparation method thereof

A technology of sutures and polyglycolic acid, which is applied in the field of medical sutures, can solve the problems of non-absorption, increase the pain of patients, and affect the absorption process, etc., and achieve the effect of high tensile strength, no toxic side effects, and high flexural modulus

Inactive Publication Date: 2015-07-29
WUJIANG ZHENYU SEWING EQUIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing absorbable sutures are catgut and chemically synthesized sutures, which are easy to affect the absorption process due to individual differences in patients, or even non-absorbable. Absorbable sutures have low tensile strength and poor biocompatibility

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: An absorbable medical suture, comprising the following components by weight: 30 parts of polyglycolic acid, 16 parts of collagen, 2.5 parts of chitosan, 1 part of antibacterial agent, 1 part of stabilizer, biological crosslinking 2 doses.

[0014] In this embodiment, the molecular weight of the polyglycolic acid is 10000-90000, and the degradation products of polyglycolic acid are lactic acid and glycolic acid, which are intermediate products of body metabolism and have good absorbability; the bacteriostatic agent is Cinnamaldehyde, described bacteriostasis agent is natural bactericidal disinfection preservative, particularly common infection bacterium is had significant inhibitory effect; Described stabilizer is sodium polyacrylate; Described biological cross-linking agent is genipin, and described biological cross-linking agent The coupling agent is the product of geniposide hydrolyzed by β-glucosidase, which can be cross-linked with protein, collagen an...

Embodiment 2

[0016] Embodiment 2: An absorbable medical suture, comprising the following components by weight: 50 parts of polyglycolic acid, 20 parts of collagen, 3 parts of chitosan, 2 parts of antibacterial agent, 4 parts of stabilizer, biological crosslinking 6 doses.

[0017] In this embodiment, the polyglycolic acid has a molecular weight of 10,000-90,000, the antibacterial agent is cinnamaldehyde or anisaldehyde, the stabilizer is sodium polyacrylate, and the biological crosslinking agent is genipin.

[0018] The preparation method of the absorbable medical suture comprises the following steps: weighing the required components according to the above weight ratio, placing them in a stirrer, and sealing and stirring at 90° C. for 15 minutes to obtain a premix; The material is placed in a twin-screw extruder at a controlled temperature of 240°C and a rotational speed of 350rpm to obtain a precursor after extrusion, water cooling, air-drying, and granulation; the obtained precursor is h...

Embodiment 3

[0019] Embodiment 3: An absorbable medical suture, comprising the following components by weight: 40 parts of polyglycolic acid, 18 parts of collagen, 2.5 parts of chitosan, 1.5 parts of antibacterial agent, 3 parts of stabilizer, biological crosslinking 4 doses.

[0020] In this embodiment, the polyglycolic acid has a molecular weight of 10,000-90,000, the antibacterial agent is cinnamaldehyde or anisaldehyde, the stabilizer is sodium polyacrylate, and the biological crosslinking agent is genipin.

[0021] The preparation method of the absorbable medical suture comprises the following steps: weighing the required components according to the above weight ratio, placing them in a stirrer, and sealing and stirring at 80° C. for 20 minutes to obtain a premix; The material is placed in a twin-screw extruder at a controlled temperature of 230°C and a rotational speed of 380rpm to obtain a precursor after extrusion, water cooling, air-drying, and pelletizing; the obtained precursor ...

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PUM

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Abstract

The invention discloses an absorbable medical suture line. The absorbable medical suture line comprises the following components in parts by weight: 30-50 parts of polyglycolic acid, 16-20 parts of collagen, 2.5-3 parts of chitosan, 1-2 parts of a bacteriostatic agent, 1-4 parts of a stabilizer, and 2-6 parts of a biological cross-linking agent. A preparation method for the absorbable medical suture line comprises the following steps: co-mixing the required components under a certain condition, extruding, performing water-cooling, drying in the air, pelletizing, spinning, stretching in a water bath and the like. All raw materials of the obtained suture line can be absorbed and degraded in vivo, free of stimulus on tissue, and are free of toxic or side effects, and a wound is free of obvious stitching marks after being healed. The formula of the composition is reasonably designed, so that the prepared product has excellent mechanical performances of high tensile strength, high bending modulus, and the like, and has the characteristic of easiness machining and shaping without obvious individual difference, and the pains of a patient are relieved.

Description

technical field [0001] The invention relates to the field of medical sutures, in particular to an absorbable medical suture and a preparation method thereof. Background technique [0002] Suture is a special thread used for ligation and hemostasis, suture hemostasis and tissue suture in surgical operation or trauma treatment. It can be divided into two categories: absorbable suture and non-absorbable suture. Non-absorbable sutures cannot be absorbed by tissues, and need to be removed after suturing, which is easy to cause secondary infection and pain; absorbable sutures can be degraded and absorbed by the body over time. Relatively speaking, absorbable sutures have no need The advantages of removing sutures, thereby reducing the suffering of patients, while having no antigenicity and pyrogenicity, complete wound healing and other advantages. Most of the existing absorbable sutures are catgut and chemically synthesized sutures, which are easy to affect the absorption process...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/12A61L17/10D01F8/14D01F8/02D01F1/10
Inventor 胡粉义
Owner WUJIANG ZHENYU SEWING EQUIP
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