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A drug gel plaster for treating acute soft tissue injury and preparation method thereof

A technology of soft tissue injury and gel plaster, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of easily polluted clothes, easy skin irritation, poor treatment effect, etc. Achieve the effect of increasing clinical dosage, promoting blood circulation and removing blood stasis, and increasing blood circulation and removing blood stasis

Active Publication Date: 2018-01-16
中国人民解放军西部战区总医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Soft tissue injury is a common disease in surgery. At present, traditional Chinese medicine transdermal preparations are generally used to treat soft tissue injuries. Traditional Chinese medicine transdermal preparations have a long history and a wide variety, such as external ointment for smearing or sticking on the outside of the skin. Ordinary plasters, however, external ointments are not easy to maintain, and are easy to contaminate clothes, while ordinary ordinary plasters, such as Shangshi Pain Relief Ointment, are mostly made of biological powder and used as medicine to make mud-like ointment, which has poor air permeability and moisture retention, and Easy to age, easy to produce irritation to the skin and other disadvantages
[0003] With the advancement of pharmaceutical technology and the application of new pharmaceutical excipients, especially high-molecular pharmaceutical materials, a new dosage form for transdermal drug delivery has been developed, which is a gel plaster. However, there is no extraction for the treatment of soft tissue injuries. A report on the active ingredients of a variety of Chinese medicinal materials prepared into a stereotyped gel paste
[0004] In addition, among the external drugs currently used to treat soft tissue injuries, on the one hand, they are affected by the ingredients of the drugs used, on the other hand, the dosage is inaccurate, and there are generally disadvantages such as poor therapeutic effect or certain toxic and side effects.

Method used

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  • A drug gel plaster for treating acute soft tissue injury and preparation method thereof
  • A drug gel plaster for treating acute soft tissue injury and preparation method thereof
  • A drug gel plaster for treating acute soft tissue injury and preparation method thereof

Examples

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preparation example Construction

[0050] A preparation method for a drug gel plaster for the treatment of acute soft tissue injury, comprising the following steps:

[0051] Step 1, extracting notoginseng, Duyiwei, rhubarb charcoal and comfrey with ethanol to obtain an extract, and concentrating the extract to obtain a thick paste;

[0052] Step 2, diluting the gelatin 5-15 times to fully swell the gelatin, heating to dissolve it, and mixing it with the obtained thick paste and silicon dioxide to obtain a medicinal solution;

[0053] Step 3: After mixing borneol, sodium polyacrylate, povidone, sodium carboxymethylcellulose, carbomer, aluminum hydroxide, ethylparaben and glycerin, add the liquid medicine, keep at 45-60°C and The drug gel is obtained by stirring, and the drug gel is coated to obtain the gel plaster.

[0054] In the preparation method of the drug gel plaster for the treatment of acute soft tissue injury, the ethanol extraction method described in step one is:

[0055] 1.1 Grinding powder, grindi...

Embodiment 1

[0064] A drug gel plaster for treating acute soft tissue injury, which is made of the following traditional Chinese medicine raw materials in proportion by mass: 30 parts of Panax notoginseng, 10 parts of Duyiwei, 30 parts of rhubarb charcoal, 30 parts of comfrey, and borneol 5 servings. It also contains a gel matrix, the mass ratio of the gel matrix to the raw material of traditional Chinese medicine is 1:2, and the gelatin matrix is ​​composed of gelatin, silicon dioxide, sodium polyacrylate, povidone, sodium carboxymethyl cellulose, carbopol Molybdenum, aluminum hydroxide, ethylparaben, and glycerin are mixed in a mass ratio of 15:10:10:10:5:2:2:0.3:200.

[0065] Prepared by the following steps:

[0066] (1) Grinding, taking Panax notoginseng, Duyiwei, rhubarb charcoal and comfrey, grinding them into powder, passing through a 120-mesh sieve to obtain drug powder, and set aside;

[0067] (2) Extraction, for the first extraction, add 7 times the amount of 70% ethanol to the...

Embodiment 2

[0070] Taking the production of 1000 medicated gel plasters of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their mass proportions are:

[0071]

[0072]

[0073] The preparation method of drug gel plaster of the present invention comprises the following steps:

[0074] (1) Grinding powder. Take 3000g of Panax notoginseng, 1000g of Duyiwei, 3000g of rhubarb charcoal, and 3000g of comfrey, grind them into powder, pass through a 120-mesh sieve, and obtain the drug powder for later use;

[0075] (2) Extraction. For the first extraction, add 7 times the amount of 70% ethanol to the drug powder, soak for 2 hours, reflux extraction for 1 hour, add 6 times the amount of 70% ethanol for 1 hour, reflux extraction for 1 hour, combine the extracts, and recover the ethanol until there is no alcohol continue to concentrate to a thick paste with a relative density of 1.15-1.20 (measured at 60°C), and set aside; take 300g of...

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Abstract

The invention discloses a medicinal gel plaster for treating acute soft tissue injury and a preparation method thereof, which comprises the following raw materials in parts by weight: Panax notoginseng 10-50, Duyiwei 6-12, rhubarb charcoal 10-50, and comfrey 10-12 50. Borneol 1-9 and gel base 30-85; wherein, the gel base includes gelatin 10-20, silicon dioxide 5-15, sodium polyacrylate 5-15, povidone 5-15, carboxymethyl fiber Sodium Sulfate 3‑8, Carbomer 1‑3, Aluminum Hydroxide 1‑3, Ethyl Paraben 0.1‑0.5, and Glycerin 150‑260. Extract Panax notoginseng, Duyiwei, rhubarb charcoal and comfrey with ethanol and concentrate to obtain a thick paste; gelatin is diluted and dissolved, and mixed with thick paste and silicon dioxide to obtain a medicinal solution; After the components are mixed, add the medicinal solution, keep warm and stir to obtain the medicinal gel, and apply the medicinal gel to obtain the medicinal gel plaster.

Description

technical field [0001] The invention relates to the field of externally used medicines for treating soft tissue injuries, in particular to a gel plaster made of traditional Chinese medicine that can efficiently treat acute soft tissue injuries and a preparation method thereof. Background technique [0002] Soft tissue injury is a common disease in surgery. At present, traditional Chinese medicine transdermal preparations are generally used to treat soft tissue injuries. Traditional Chinese medicine transdermal preparations have a long history and a wide variety, such as external ointment for smearing or sticking on the outside of the skin. Ordinary plasters, however, external ointments are not easy to maintain, and are easy to contaminate clothes, while ordinary ordinary plasters, such as Shangshi Pain Relief Ointment, are mostly made of biological powder and used as medicine to make mud-like ointment, which has poor air permeability and moisture retention, and Easy to age, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/708A61K9/70A61K36/85A61P29/00A61P19/04A61K31/045A61K35/64
Inventor 呼永河侯君周龙甫郑德志
Owner 中国人民解放军西部战区总医院