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Method for preparing soybean isoflavone aglycone by catalyzing soybean isoflavone glycoside to hydrolyze through lactic acid

A technology of lactic acid catalyzing glycosides and soybean isoflavones, applied in the direction of organic chemistry, etc.

Inactive Publication Date: 2015-08-19
JILIN INST OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of the technical defects of hydrochloric acid catalysis, alkali catalysis and enzyme catalysis in the existing process of converting soybean isoflavones to aglycones, edible lactic acid is used to catalyze the hydrolysis process of soybean isoflavones, which is simple to operate, less acidic, does not pollute the environment, and is completely hydrolyzed

Method used

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Embodiment Construction

[0004] Take 30 mg of 91.3% soybean isoflavone glycosides and place in a 50 mL round bottom flask, add 2.0 mol L -1 Add 7mL of acetic acid aqueous solution, and then add 3ml of absolute ethanol, ultrasonic water bath for 1 hour, ultrasonic frequency 45KHz, water bath temperature 75°C. The reaction liquid was transferred to an autoclave, the reaction temperature was 163° C., and the reaction time was 2.5 hours. After the reaction was completed, the reaction liquid was cooled to room temperature. Take a certain amount of the reaction solution and neutralize it with saturated sodium carbonate aqueous solution to pH = 7, extract with ethyl acetate, take the ester layer, spot on a silica gel plate, put in a developing solvent (ethyl acetate: chloroform: methanol = 5:5 : 2) Expand in middle, observe the degree of hydrolysis under ultraviolet light; take another certain amount of reaction solution and dilute it to 100ppm with methanol, use HPLC to qualitatively and quantitatively det...

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Abstract

The invention discloses a method of preparing soybean isoflavone aglycone by catalyzing soybean isoflavone glycoside to hydrolyze through lactic acid. According to the method, 91.3% of glucoside type soybean isoflavone glycoside are used as raw materials, the food additive level lactic acid is used as a cytalyst, and the soybean isoflavone glycoside in the raw materials is hydrolyzed to be soybean isoflavone aglycone under certain pressure at a certain temperature, wherein the hydrolysis rate of the soybean isoflavone glycoside is 100%. The method is simple to operate, and more importantly, lactic acid can be used as the catalyst, so that the hydrolysis process is environmentally friendly, hydrolyzed products can be directly applied to soyabean health care products and functional foods without the needs of separating, and the problems of equipment corrosion, waste water pollution and poor edible product safety in a catalyzing process using mineral acid are solved. The invention is a practical technology applicable to industrialized production of the soybean isoflavone aglycone.

Description

technical field [0001] The invention relates to a method for preparing soybean isoflavone aglycone by catalyzing soybean isoflavone glucoside hydrolysis with lactic acid. Background technique [0002] Soy isoflavones are secondary metabolites produced during the growth of soybeans and other leguminous plants. Studies have found that intake of sufficient amounts of soy isoflavones can effectively reduce the risk of osteoporosis, climacteric syndrome, and hypercholesterolemia. , and the risk of cardiovascular disease and cancer. There are three main types of isoflavones naturally present in soybeans, namely genistein, daidzein and glycitein, each of which exists in four main forms: malonyl Glucoside type, acetyl glucoside type, β-glucoside type and aglycone type (aglycone), among which the combined glycoside accounts for 80% to 95% of the total isoflavone content. Studies have found that soybean isoflavones in the form of glycosides cannot be directly absorbed by the small i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/36
CPCC07D311/36
Inventor 于丽颖成乐琴谭乃迪张鹏
Owner JILIN INST OF CHEM TECH
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