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Swelling hollow silk fibroin microneedle drug delivery system and preparation method thereof

A drug delivery system and silk fibroin technology are applied to the swollen hollow silk fibroin microneedle drug delivery system and the field of preparation thereof, which can solve the problem of weak hollow microneedles with controlled release of drugs, low drug loading rate, difficult practical operation, etc. problems, to simplify the structure of the hollow microneedle transdermal drug delivery system, reduce skin sensitization and irritation, and facilitate sustained and controlled release.

Active Publication Date: 2017-12-22
PHARSUN MEDICAL BIOTECHNICS (SHANGHAI) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the poor biocompatibility, low drug loading rate, weak drug release control and hollow microneedle preparation technology of existing glass, silica, silicon and metal solid microneedles, the technology is complicated, the technology is difficult, the equipment requirements are high, The finished product has defects such as complex structure and difficult practical operation, and in view of the deficiencies in the controlled release of soluble and insoluble polymer microneedles, the purpose of the present invention is to provide a short production process, mild processing conditions, and a simple and practical finished product structure. Swellable hollow silk fibroin microneedle drug delivery system with convenient operation, excellent drug control release and suitable for large-scale production and preparation method thereof

Method used

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  • Swelling hollow silk fibroin microneedle drug delivery system and preparation method thereof
  • Swelling hollow silk fibroin microneedle drug delivery system and preparation method thereof
  • Swelling hollow silk fibroin microneedle drug delivery system and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0034] (1) Preparation of silk fibroin solution: take 80g of silkworm silk and put it into 4000ml of 0.06% sodium carbonate solution, boil it three times at 98-100°C, and use deionized water for three times, each time for 30min, remove The sericin in the raw silk is washed, loosened and then dried in an oven at 60°C to obtain pure silk fiber. Dissolve the pure silk fiber obtained by drying in 9.3mol / L lithium bromide solution at 60°C, the bath ratio is 3:20, and the dissolution time is about 1h. After cooling, take it out and put it into a dialysis bag and place it in deionized water Dialyze for 3 days, filter with absorbent cotton to obtain a pure silk fibroin solution, concentrate it at room temperature, and put it in a 4°C refrigerator for later use.

[0035] (2) Modification of silk fibroin solution: the small molecule swelling agent glucosamine hydrochloride is diluted to 0.2g / mL with pure water, and the pure silk fibroin solution in (1) is in mass ratio (M swelling agent...

specific Embodiment 2

[0040] (1) Preparation of silk fibroin solution: take 80g of silkworm silk and put it into 4000ml of 0.06% sodium carbonate solution, boil it three times at 98-100°C, and use deionized water for three times, each time for 30min, remove The sericin in the raw silk is washed, loosened and then dried in an oven at 60°C to obtain pure silk fiber. Dissolve the pure silk fiber obtained by drying in 9.3mol / L lithium bromide solution at 60°C, the bath ratio is 3:20, and the dissolution time is about 1h. After cooling, take it out and put it into a dialysis bag and place it in deionized water Dialyze for 3 days, filter with absorbent cotton to obtain a pure silk fibroin solution, concentrate it at room temperature, and put it in a 4°C refrigerator for later use.

[0041] (2) Modification of silk fibroin solution: the small molecule swelling agent dimethylformamide was diluted to 0.1g / mL with pure water, and the pure silk fibroin solution in (1) was mass ratio (M swelling agent / M silk ...

specific Embodiment 3

[0046] (1) Preparation of silk fibroin solution: take 80g of silkworm silk and put it into 4000ml of 0.06% sodium carbonate solution, boil it three times at 98-100°C, and use deionized water for three times, each time for 30min, remove The sericin in the raw silk is washed, loosened and then dried in an oven at 60°C to obtain pure silk fiber. Dissolve the pure silk fiber obtained by drying in 9.3mol / L lithium bromide solution at 60°C, the bath ratio is 3:20, and the dissolution time is about 1h. After cooling, take it out and put it into a dialysis bag and place it in deionized water Dialyze for 3 days, filter with absorbent cotton to obtain a pure silk fibroin solution, concentrate it at room temperature, and put it in a 4°C refrigerator for later use.

[0047] (2) Modification of silk fibroin solution: the small molecule swelling agent biuret is diluted to 0.07g / mL with pure water, and the pure silk fibroin solution in (1) is mass ratio (M swelling agent / M silk fibroin ) = ...

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Abstract

The invention discloses a swelling-type hollow silk fibroin micro-needle drug delivery system and a preparation method thereof. According to the technical scheme of the preparation method, a swelling modified silk fibroin solution is casted in a PDMS mold to be vacuumized, dried and molded as a hollow needle-type housing. After that, a silk fibroin micro-needle array provided with cavities in the hollow needle-type housing is filled with powder-like or solution-like drugs, vacuumizing and drying are carried out to form a drug part. Finally, a layer of modified silk fibroin solution is cast, dried and molded as a cladded coating. The cladded coating is removed to obtain the swelling-type hollow silk fibroin micro-needle drug delivery system. The drugs are wrapped inside the cavities of the silk fibroin micro-needle arrays, so that the system is high in drug loading ratio and low in skin allergenicity and stimulation. The system facilitates the sustained release and the controlled release of micro-needle drugs. Meanwhile, according to the preparation method, since the swelling modified silk fibroin solution is cast, dried and molded in a mild processing condition, the system is low in processing cost and suitable for large-scale production. Drugs are directly wrapped in the cavities of the swelling hollow micro-needles, so that controlled-release drugs are swelled in the micro-needle base material. In this way, the biological activities of the controlled-release drugs are maintained, while the structure of the hollow silk fibroin micro-needle drug delivery system is greatly simplified. The system is better in practicality.

Description

technical field [0001] The invention relates to a medical microneedle drug delivery system, in particular to a swellable hollow silk fibroin microneedle drug delivery system and a preparation method thereof. Background technique [0002] With the development of micro-processing technology, a micro-needle technology that can pierce the epidermis without hurting the dermis and nerves came out more than ten years ago, bringing new ideas for transdermal drug delivery. The microneedle lattice with a size of micron punctures the extremely poorly permeable skin surface (stratum corneum) in a reversible and minimally invasive way, creating a mechanical channel through which biomacromolecules can pass without causing pain and skin trauma. However, the current microneedle drug delivery technology still has many technical bottlenecks, mainly including complex molding technology, high manufacturing cost, toxicity of microneedle materials, poor biocompatibility, easy to break and remain ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/42
CPCA61M37/0015A61M2037/0046A61M2037/0053
Inventor 殷祝平卢神州任敬霞张淑敏王小莹夏婷婷
Owner PHARSUN MEDICAL BIOTECHNICS (SHANGHAI) CO LTD
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