Compositions, formulations, applications thereof, methods of preparation and methods of use

A composition and preparation technology, applied in the field of compositions, can solve the problems of poor stability, high injection frequency, and insignificant improvement of melanin.

Active Publication Date: 2018-09-04
GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In terms of ingredients, the whitening preparations in the prior art are mainly tranexamic acid (TXA) and natural vitamin C (NVc), and some natural herbal essences are added; wherein tranexamic acid can only make dark spots no longer thicken and expand And increase, so as to prevent and improve the pigmentation of the skin, but it has no obvious effect on the improvement of melanin accumulated in the early stage; through the intake of vitamin C to obtain the effects of whitening, anti-oxidation, and promotion of collagen synthesis, at least 1000mg of vitamin C is required every day However, long-term intake of large doses of vitamin C will promote the absorption of iron in the blood system, cause iron-rich red blood cell anemia, and reduce the intestinal absorption of vitamin B12, which will accelerate the deterioration of megaloblastic anemia. Lead to hemolysis, severe cases can be fatal, sudden withdrawal after long-term large doses may cause rebound scurvy, causing certain damage to the digestive system, urinary system, etc. cause a certain impact, to avoid the menstrual period
[0007] The above uses the principle of anti-oxidation to inhibit the formation of melanin, but it cannot change its own physique. After the injection, with the gradual production of melanin, it will still return to the previous state, and the stability is not good; and it will cause the blood coagulation function of the body. Certain effects, long treatment cycle, high injection frequency

Method used

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Examples

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preparation example Construction

[0045] The application also provides a preparation method of the preparation, comprising the following steps:

[0046] mixing hyaluronidase with a solvent to obtain a first preparation;

[0047] The second preparation is obtained by mixing deer antler essence, vitamin C, persimmon leaf extract, autologous platelet-rich plasma, autologous platelet-rich plasma activator and hyaluronic acid.

[0048] The preparation methods of the autologous platelet-rich plasma (PRP) and the autologous platelet-rich plasma (HT) have been described in detail, and will not be repeated here.

[0049] The preparations provided by this application include the first preparation and the second preparation, wherein the first preparation contains hyaluronidase, which promotes the hydrolysis of hyaluronic acid in the extracellular matrix, reduces the hindrance of the extracellular matrix to the injection of nutrients, and improves the elasticity of the dermal tissue. Permeability, thereby improving the p...

Embodiment 1

[0051] The preparation of embodiment 1 autologous platelet-rich plasma (PRP)

[0052] 1) Collect 10-20ml of autologous peripheral blood;

[0053] 2) Centrifuge the blood for the first time (400G, 5min);

[0054] 3) The centrifuge tube can be roughly divided into 3 layers from top to bottom: supernatant, platelet-rich layer and red blood cell layer, extract the upper yellow supernatant and the 2mm red blood cell layer at the junction, and perform a second centrifugation (400G, 10min) ;

[0055] 4) After extracting all the supernatant, divide it into two centrifuge tubes, extract 4ml from one tube and keep it as the subsequent preparation of autologous PRP activator, and perform the third centrifugation (1200G, 5min) on the remaining one to extract the upper plasma And leave about 1-2ml of PRP at the bottom of the tube.

Embodiment 2

[0057] 1) Let the 2-4ml of the above-mentioned reserved supernatant stand for 30 minutes and then centrifuge (800G, 15 minutes);

[0058] 2) Then remove the upper layer of plasma, keep the bottom 0.75 ~ 1.5ml of plasma, and then mix it with 5% ~ 10% CaCl at a ratio of 3:1 2 Mixed (HT: CaCl 2 =3:1), to obtain 1-2ml of PRP activator (HT) modulated by homemade thrombin.

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PUM

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Abstract

The invention provides a composition, the application thereof and a preparation. The composition comprises a component A and a component B. The preparation comprises a first preparation and a second preparation, wherein the first preparation comprises hyaluronidase and a solvent acceptable on medicine, the second preparation comprises autologous platelet-rich plasma, an autologous platelet-rich plasma activator, cornua cervi pantotrichum essence, vitamin C, a persimmon leaf extracting solution and hyaluronic acid. The hyaluronidase in the first preparation improves nutrient substance infiltration and diffusion, the second preparation can directly repair damaged skin, remove melanin and harmful free radical, and the face skin becomes delicate and white; the stability of later treatment period can be well kept by means of the moisturizing function of the hyaluronic acid, so that the skin whitening effect is obvious, and the holding time is long.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a composition, a preparation, an application, a preparation method and a use method thereof. Background technique [0002] Melanocytes can block the penetration of ultraviolet rays and protect the dermis and subcutaneous tissue from ultraviolet light and chemical drugs. At the same time, melanin itself is a relatively stable free radical, which can neutralize various free radicals to form stable chemical bonds to reduce Free radicals damage normal cells, but the amount of melanin produced by melanocytes is the main factor that changes skin color. [0003] There are many reasons for skin dullness and spots. The main influencing factors are the two major factors of its own internal environment and external environment. From the perspective of its own internal environment, the metabolic function of the body is affected by irregular life and bad eating habits. As a result, body to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/47A61K36/44A61P17/00A23L33/00A61K8/98A61K8/9789A61K8/66A61K8/67A61K8/73A61Q19/02A61K35/16A61K35/32A61K31/375
Inventor 陈海佳王一飞葛啸虎李丽娟万桦
Owner GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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