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A kind of bone tissue engineering honeycomb scaffold material and preparation method thereof

A technology of bone tissue engineering and scaffold materials, applied in the field of bone tissue engineering honeycomb scaffold materials and its preparation, and biomedical materials, can solve the problems of high cost, large pore size of scaffolds, heavy metal pollution, etc., and achieve cost economy and porosity Suitable, toughness-enhancing effect

Active Publication Date: 2017-07-07
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problems to be solved by the present invention are that the traditional metal template extrusion method is expensive, easily causes heavy metal pollution, and the gap size of the bracket is too large.

Method used

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  • A kind of bone tissue engineering honeycomb scaffold material and preparation method thereof
  • A kind of bone tissue engineering honeycomb scaffold material and preparation method thereof
  • A kind of bone tissue engineering honeycomb scaffold material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The components of the hydroxyapatite whisker honeycomb bone scaffold prepared in this example are hydroxyapatite whiskers and silicon dioxide, wherein the mass percentage of hydroxyapatite whiskers is 82.5%, and the mass percentage of silicon dioxide is 17.5% , the average extrusion pore size is 380μm, the average pore wall thickness is 260μm, the average porosity is 72%, and the compressive strength is 1.15MPa.

[0031] The preparation method of the bone tissue engineering honeycomb scaffold material in this embodiment specifically comprises the following steps:

[0032] (1) According to the mass ratio of konjac glucomannan, silica sol, and distilled water of 1:3.53:25, add konjac glucomannan into the diluted silica sol and mix evenly to obtain gel A. The mass of silica sol The percentage concentration is 25wt%;

[0033] (2) adding hydroxyapatite whiskers to gel A at a mass ratio of hydroxyapatite whiskers to the silica sol described in step (1) of 82.5:17.5;

[0034...

Embodiment 2

[0038] The components of the hydroxyapatite whisker honeycomb bone scaffold prepared in this example are hydroxyapatite whiskers and silicon dioxide, wherein the mass percentage of hydroxyapatite whiskers is 80%, and the mass percentage of silicon dioxide is 20% , the average extrusion pore size is 380μm, the average pore wall thickness is 260μm, the average porosity is 68%, and the compressive strength is 1.29MPa.

[0039] The preparation method of the bone tissue engineering honeycomb scaffold material in this embodiment specifically comprises the following steps:

[0040] (1) According to the mass ratio of konjac glucomannan, silica sol, and distilled water of 1:4:25, add konjac glucomannan into the diluted silica sol and mix evenly to obtain gel A. The mass of silica sol The percentage concentration is 30wt%;

[0041] (2) adding hydroxyapatite whiskers to gel A at a mass ratio of hydroxyapatite whiskers to the silica sol described in step (1) of 80:20;

[0042] (3) Extrude...

Embodiment 3

[0045] The components of the hydroxyapatite whisker honeycomb bone scaffold prepared in this example are hydroxyapatite whiskers and silicon dioxide, wherein the mass percentage of hydroxyapatite whiskers is 83%, and the mass percentage of silicon dioxide is 17%. , the average extrusion pore size is 380μm, the average pore wall thickness is 260μm, the average porosity is 80%, and the compressive strength is 1.06MPa.

[0046] The preparation method of the bone tissue engineering honeycomb scaffold material in this embodiment specifically comprises the following steps:

[0047] (1) According to the mass ratio of konjac glucomannan, silica sol, and distilled water of 1:3:25, add konjac glucomannan into the diluted silica sol and mix evenly to obtain gel A. The mass of silica sol The percentage concentration is 10wt%;

[0048] (2) adding hydroxyapatite whiskers to gel A at a mass ratio of hydroxyapatite whiskers to the silica sol described in step (1) of 83:17;

[0049] (3) The ...

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Abstract

The invention discloses a bone tissue engineering honeycomb support material and a preparation method thereof, belonging to the technical application field of biomedical materials. The hydroxyl bone tissue engineering honeycomb support material prepared by the present invention is composed of base apatite whiskers and silicon dioxide mass. Dissolve konjac glucomannan in silica sol diluted with distilled water to obtain gel, and add hydroxyapatite whiskers and PMMA microspheres to the gel, and stir evenly to obtain scaffold mud; the mud is extruded and solidified , drying, heat treatment and other processes, and finally the hydroxyapatite whisker honeycomb scaffold was prepared. The preparation of the scaffold has the advantages of simple and controllable process, economical cost of raw materials, no heavy metal pollution in the finished product, and short cycle time. Cell and animal experiments of the hydroxyapatite whisker honeycomb bone scaffold prepared by the method show that the cytotoxicity is qualified and the osteogenesis effect is good. Therefore, it is expected to realize industrial production and clinical application.

Description

technical field [0001] The invention relates to a bone tissue engineering honeycomb support material and a preparation method thereof, belonging to the technical application field of biomedical materials. Background technique [0002] Bone defects caused by diseases such as osteoporosis and osteonecrosis and traffic accidents are clinically very common diseases. The sources of bone grafts after bone defects mainly include autologous bone and allogeneic bone. Autologous bone extraction is limited, which increases the pain of the patient and often causes morbidity at the extraction site. Allograft bone is quite difficult in material screening, storage, etc., and often produces rejection. In order to overcome the above-mentioned problems of autologous bone and allogeneic bone implanted in bone defects, bone tissue engineering scaffold materials have emerged as the times require. [0003] There are many methods for preparing scaffolds for bone tissue engineering, such as extr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/20A61L27/02A61L27/50A61L27/56
Inventor 陈庆华谌强国颜廷亭陶世刚
Owner KUNMING UNIV OF SCI & TECH