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Antibacterial composition for skin and mucous membrane

An antibacterial composition and skin technology, applied in the directions of skin diseases, antibacterial drugs, drug combinations, etc., can solve the problems of tooth staining, loss of taste, easy to be hydrolyzed by protease, inactivation of high salt ions, etc., so as not to cause drug resistance. , Skin and mucous membrane irritation is low, the effect is remarkable

Active Publication Date: 2015-12-16
HANGZHOU ADVANCED BIOSCIENCE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Triclosan has been reported to have carcinogenic effect. Although there is no scientific research to prove that triclosan can cause cancer, recent research results show that triclosan can cause liver cancer and liver fibrosis in mice. Closely
In October 2007, a class action lawsuit filed in the U.S. state of Georgia alleges that many users of Procter & Gamble's mouthwash with the active ingredient cetylpyridinium chloride stained their teeth and lost their sense of taste
[0010] In addition, antimicrobial peptides have other disadvantages, including: short half-life in vivo, easy inactivation by high salt ions, easy hydrolysis by proteases, high production costs, etc.
The above characteristics of antimicrobial peptides seriously restrict its application in products

Method used

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  • Antibacterial composition for skin and mucous membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The selection of embodiment 1 antimicrobial peptides.

[0040] Antimicrobial peptides have various effects such as broad-spectrum antibacterial, anti-inflammatory, and immune regulation. However, the characteristics of each antimicrobial peptide are different.

[0041] In practical applications, how to choose the appropriate type and dose of antimicrobial peptides needs to consider whether they can meet the requirements of safety and effectiveness in the field of application. When it comes to the treatment of skin and mucous membrane diseases, safety means low irritation to skin and mucous membranes and no allergic reaction. When selecting antimicrobial peptides, the first consideration is whether they are toxic to cells. Effectiveness means that it can inhibit or kill the main pathogenic microorganisms in the skin and mucous membranes, and the effectiveness will be introduced in subsequent examples.

[0042] Based on the analysis of the structure-activity relationship...

Embodiment 2

[0049] Embodiment 2 Skin mucous membrane antibacterial composition formula.

[0050] The antimicrobial peptide in the composition is a polypeptide with an amino acid sequence as shown in SEQ.NO.1. The antimicrobial peptide in the present invention can be chemically synthesized, or expressed, isolated and purified by genetic engineering techniques (see Sambrooke et al. ., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989). The antimicrobial peptide concentration in the skin and mucous membrane antibacterial composition is: 62.5-2000 ppm; preferably: 62.5-1000 ppm; more preferably: 125-500 ppm. The antimicrobial peptides in the composition can inhibit the adhesion and growth of pathogenic bacteria on skin and mucous membranes, kill pathogenic bacteria, and maintain the health of human skin and mucous membranes.

[0051] The stabilizer in the composition can maintain the correct conformation of the antibacterial peptide and...

Embodiment 3

[0061] The preparation method of embodiment 3 skin and mucous membrane antibacterial composition.

[0062] This preparation method is an example of each combined component in Example 2, and does not represent any limitation to the composition of the present invention.

[0063] The preparation steps are as follows.

[0064] A1:

[0065] 1. In 1000ml of purified water, add 10ml of glycerin and stir well;

[0066] 2. After mixing 62.5 mg of antimicrobial peptides, add them to the glycerin solution in the previous step, and stir evenly;

[0067] 3. Adjust the pH value to 7.0 to obtain the anti-caries oral spray for children.

[0068] B1:

[0069] 1. In 1000ml of purified water, add 5ml of glycerin and stir well;

[0070] 2. After mixing 1000mg antimicrobial peptide and 2g arginine, add it to the glycerin solution in the previous step, and stir evenly;

[0071] 3. Adjust the pH value to 5.0 to obtain antibacterial lotion for women.

[0072] C1:

[0073] 1. In 1000ml of puri...

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Abstract

The invention provides antibacterial composition for the skin and the mucous membrane. The composition comprises antimicrobial peptide with the sequence shown as SEQ ID NO.1 as well as a proper additive which adopts a stabilizer and can further comprise a skin and mucous membrane recovery conditioner. Aiming at the defects of high side effects, high irritation and high drug resistance of the conventional antimicrobial products, the antibacterial composition for the skin and the mucous membrane has the advantages of low irritation, drug resistance avoidance, good effect and the like due to scientific component matching, has the antibacterial effect on multiple microbes and can be used for antibacterial cleaning, nursing and treatment of the skin, the mucous membrane and the like of a human body.

Description

technical field [0001] The invention relates to the fields of daily chemicals, disinfection, medicine and medical equipment, especially the skin and mucous membrane antibacterial composition. Background technique [0002] In the event of damage from external physical and chemical factors, invasion of pathogenic microorganisms, human endocrine and metabolic disorders, and other primary systemic diseases, a series of diseases will appear on human skin and mucous membranes, such as chronic inflammatory skin diseases involving pilosebaceous glands, Acne, commonly known as "acne", occurs in infants and young children, and eczema also exists in adults, common oral diseases such as periodontitis, oral ulcers, dental caries, etc., and gynecological diseases with high incidence in women. [0003] Pathogenic microorganisms, such as Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Propionibacterium acnes, Porphyromonas gingivalis, Streptococcus mutans,...

Claims

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Application Information

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IPC IPC(8): A61K38/10A61P31/04A61P17/02A61P31/00A61P1/02A61K8/64A61Q19/00A61Q11/00
Inventor 凌建群余海赵玲
Owner HANGZHOU ADVANCED BIOSCIENCE CO LTD
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