A method for preparing β-tricalcium phosphate based on multidimensional swinging nanometer ball milling

A multi-dimensional swing, tricalcium phosphate technology, applied in chemical instruments and methods, phosphorus compounds, medical science, etc., can solve problems such as large particle size of raw materials, existence of β-tricalcium phosphate impurity phase, imbalance of calcium-phosphorus atomic ratio, etc. Achieve sufficient solid phase reaction, facilitate mass production, and improve the effect of purity

Active Publication Date: 2017-12-01
SOUTH CHINA UNIV OF TECH
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

The more mature dry process mainly includes solid-phase synthesis. The traditional solid-phase synthesis uses a planetary ball mill to grind the mixed raw materials. The particle size of the raw materials after ball milling is relatively large. The atomic ratio of calcium and phosphorus is out of balance, resulting in the presence of impurity phases in the prepared β-tricalcium phosphate

Method used

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  • A method for preparing β-tricalcium phosphate based on multidimensional swinging nanometer ball milling
  • A method for preparing β-tricalcium phosphate based on multidimensional swinging nanometer ball milling
  • A method for preparing β-tricalcium phosphate based on multidimensional swinging nanometer ball milling

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Experimental program
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Effect test

Embodiment 1

[0027] Dicalcium phosphate and calcium carbonate were ball-milled for 6 hours at a speed of 300r / min using a multi-dimensional swinging nano ball mill, and then the calcium hydrogen phosphate (CaHPO 4 2H 2 O) 37.86g and calcium carbonate (CaCO 3 ) 11.81g, and then add 70mL of absolute ethanol; the above-mentioned mixed solution was stirred electrically for 3h under ultrasonic to make it fully mixed and dispersed evenly to obtain a slurry; the slurry was dried in an oven, and then placed in a muffle furnace at Calcining at 900° C. for 3 hours to obtain a powder; finally, dispersing the calcined powder in deionized water and drying by suction filtration to obtain a β-tricalcium phosphate powder.

[0028] In this embodiment, the average particle diameter of calcium hydrogen phosphate and calcium carbonate after ball milling by a multidimensional swinging nano ball mill is compared with the average particle diameter after ball milling by an ordinary planetary ball mill, and the r...

Embodiment 2

[0030] Using a multi-dimensional swinging nano ball mill with a speed of 500r / min, calcium pyrophosphate and calcium carbonate were ball milled for 12 hours respectively, and then the calcium pyrophosphate (Ca 2 P 2 o 7 )45.91g and calcium carbonate (CaCO 3 ) 18.09g, and then add 100mL of deionized water; the above mixed solution was stirred electrically for 4h under ultrasonic to make it fully mixed and dispersed evenly to obtain a slurry; the slurry was dried in an oven, and then placed in a muffle furnace at Calcining at 1000° C. for 2 hours to obtain a powder; finally, dispersing the calcined powder in deionized water and drying by suction filtration to obtain a β-tricalcium phosphate powder.

Embodiment 3

[0032] Calcium pyrophosphate and calcium hydroxide were respectively ball-milled for 9 hours at a speed of 400r / min by a multi-dimensional swinging nano ball mill, and then the calcium pyrophosphate (Ca 2 P 2 o 7 )45.91g and calcium hydroxide (Ca(OH) 2 ) 13.39g, and then add 90mL of absolute ethanol; the above-mentioned mixed solution was stirred electrically for 4h under ultrasonic to make it fully mixed and dispersed evenly to obtain a slurry; the slurry was dried in an oven, and then placed in a muffle furnace at Calcining at 850° C. for 3 hours to obtain a powder; finally, dispersing the calcined powder in deionized water and drying by suction filtration to obtain a β-tricalcium phosphate powder.

[0033] The XRD spectrogram of embodiment 1~3 gained β-tricalcium phosphate powder and the contrast figure of standard spectrogram are as follows image 3 Shown; its IR spectrum is shown in Figure 4 shown. Depend on image 3 and Figure 4 It can be seen that the β-tricalc...

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Abstract

The invention belongs to the technical field of biomedical materials, and discloses a method for preparing β-tricalcium phosphate based on multidimensional swinging nanometer ball milling. The method comprises the following preparation steps: using a multi-dimensional swinging nanometer ball mill to mill phosphorus-containing raw materials and calcium-containing raw materials respectively, then proportioning the processed raw materials and adding a volatile dispersant, mixing and dispersing under ultrasonic and stirring conditions uniform to obtain a slurry; dry the slurry to remove the dispersant, and then calcine at a high temperature for solid-state reaction to obtain a powder; disperse the powder in deionized water, filter it with suction, and obtain β-tricalcium phosphate after drying. The invention adopts the multi-dimensional swinging nanometer ball milling processing technology, and the process is stable and simple, which is beneficial to batch production, and the obtained β-tricalcium phosphate has high purity and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a method for preparing beta-tricalcium phosphate based on multidimensional swinging nanometer ball milling. Background technique [0002] β-tricalcium phosphate not only has good biocompatibility, but also has excellent bioactivity and biodegradability. After implanted in the body, the material itself is transformed into a part of the host's new bone tissue through dissolution and absorption of body fluids, and finally makes the defect It is a biodegradable material with excellent performance and plays a huge role in the field of bone tissue engineering. [0003] The preparation methods of β-tricalcium phosphate generally include wet process, hydrothermal process and dry process. The wet process is synthesized by solution reaction, which can produce fine grains or amorphous powder. The wet process mainly includes three methods: chemical precipitation me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32A61L27/12
Inventor 任力王迎军康军沛刘卅杨军忠卢建熙王瑧
Owner SOUTH CHINA UNIV OF TECH
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