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A skin care composition for whitening and lightening spots

A skin care composition and composition technology, which is applied in the field of whitening and lightening cosmetic compositions, and can solve problems such as troxerutin not seen

Active Publication Date: 2016-04-20
GUANGZHOU GAOZI COSMETICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Although troxerutin is synthesized from rutin and has a similar chemical structure to rutin, it has not been seen that troxerutin is used for whitening, brightening skin tone, inhibiting melanin, and inhibiting tyrosine Enzymes are reported, in contrast troxerutin is widely used in tanning formulations, such as Merck's self-tanning formulation containing dihydroxyacetone and troxerutin

Method used

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  • A skin care composition for whitening and lightening spots
  • A skin care composition for whitening and lightening spots

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0085] Measure the effect of inhibiting melanin formation

[0086] The HM3KO cells, which are human melanoma cells, were placed in a minimal essential medium containing 10% bovine embryonic serum and cultured at 37°C and 5% CO2. Smear the cultured cells on the bottom of a 75-well flask with a cell count of 3×105 / well and leave it overnight to make the cells adhere to the wall. After confirmation, each medium was changed to a new medium containing 10 ppm experimental sample.

[0087] The experimental samples used are shown in Table 1 below.

[0088] The control group used a medium containing DMSO (dimethyl sulfoxide).

[0089] In the above manner, each medium was changed to a new medium containing the experimental sample every 2 days until the cultured cells were enough to fill the flask. Then, the medium fluid was taken out, washed with PBS (phosphate buffered saline), and re-dissolved in 1N NaOH. The optical density (OD) at 500 nm was measured, and the inhibition rate of melanin f...

experiment example 2

[0095] Skin whitening effect on human skin

[0096] An opaque tape with 6 holes with a diameter of 1.5 cm was adhered to the upper arms of each of 10 healthy men, and irradiated with an ultraviolet beam with an intensity of 1.5-2 times the minimum erythema dose of each subject. Induce skin melanin deposition. Then apply the test sample, after 2 months, use the colorimeter to measure the depth of the skin.

[0097] The experimental samples were prepared according to the composition in Table 1, and the preparations of the examples in Table 1 and the comparative preparations were applied twice a day (once in the morning and once in the evening).

[0098] table 3

[0099] Matrix formula

[0100]

[0101] Table 3 Active ingredient ratio

[0102]

[0103] The experimental results are shown in the table below

[0104] Table 4

[0105] Experimental sample

Skin whitening effect (ΔL)

Formulation 1

1.02

Formulation 2

1.21

Formulation 3

0.72

Formulation 4

3.72

Comparative preparation...

Embodiment 1

[0109] Butylene glycol 6.0

[0110] Methyl paraben 0.12

[0111] Hydroxyethyl cellulose 0.2

[0112] Polyquaternium-100.05

[0113] Troxerutin 1.5

[0114] EDTA disodium 0.15

[0115] Allantoin 0.15

[0116] Serine 2.0

[0117] Trimethylglycine 2.5

[0118] Carbomer 0.4

[0119] Caprylic / Capric Triglyceride 6.35

[0120] Cetearyl Glucoside 0.75

[0121] Cetearyl Alcohol 2.0

[0122] PEG-100 stearate 1.0

[0123] Stearic acid monoglyceride 1.0

[0124] PEG-75 Lanolin 0.2

[0125] Polydimethylsiloxane 2.0

[0126] Bisabolol 0.35

[0127] Tocopherol Acetate 2.0

[0128] Sapindus saponins 2.0

[0129] Ginsenoside 0.4

[0130] Nicotinamide 4.0

[0131] Anti-allergic agent 2.0 (Korea Youai Company sells under the trade name U-activeP8)

[0132] Phenoxyethanol 0.5

[0133] Flavor 0.35

[0134] Glycerin 4.0

[0135] Urea 0.2

[0136] Papain 3.0

[0137] Water to 100.

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PUM

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Abstract

The invention relates to skin whitening and fleck removing skin-care cosmetic composition. The composition can prevent excessive generation of melanin and realizes effects of skin whitening, fleck removing and skin brightening. Specifically, the skin whitening and fleck removing skin-care cosmetic composition contains troxerutin, sapindoside and papain. The composition realizes the effects of skin whitening, blackspot removal and skin brightening through synergistic effects of troxerutin, sapindoside and papain.

Description

Technical field [0001] The invention relates to a skin care cosmetic composition for whitening and lightening spots. Specifically, the whitening and spot-lightening cosmetic composition of the present invention contains troxerutin, sapindus saponin and papain. The composition achieves excellent skin whitening, lightening scars, and brightening skin tone effects through the synergistic effects of troxerutin, soapberry saponin and papain. Background technique [0002] When people's skin is irradiated by ultraviolet rays, it produces and releases melanin that determines the color of human skin, causing hyperpigmentation, such as melasma, freckles and spots, all of which have a bad effect on beauty. [0003] The synthesis process of melanin is as follows: the tyrosinase in the cell acts on tyrosine to form dopaquinone, thereby producing melanin. Therefore, in order to prevent the skin from darkening, researchers have devoted themselves to studying the inhibition of partial synthesis ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/66A61K8/60A61Q19/00A61Q19/02
CPCA61K8/602A61K8/66A61K2800/782A61Q19/00A61Q19/02
Inventor 韩勇
Owner GUANGZHOU GAOZI COSMETICS CO LTD