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Polyester material with antibacterial and biocompatible surface and preparing method and application thereof

A biocompatible, polyester material technology, applied in the field of polymer material surface modification, can solve the problems of poor biocompatibility, toxic effects on cells, etc., and achieve good cell compatibility, easy operation, technical mild effects

Active Publication Date: 2016-01-20
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used antibacterial agents include organic small molecule antibacterial agents containing quaternary ammonium, haloamine, guanidine and quaternary phosphine, etc., synthetic polymer antibacterial agents, chitosan and its derivatives, silver-containing compounds and other inorganic antibacterial agents and compound antibacterial agents. Etc. These antibacterial components can effectively kill surrounding bacteria and microorganisms through diffusion, or effectively kill bacteria and microorganisms adhering to the surface of the material through contact to achieve antibacterial; but the biggest risk of the introduction of antibacterial active components is the possibility of Toxic to normal cells, poor biocompatibility

Method used

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  • Polyester material with antibacterial and biocompatible surface and preparing method and application thereof
  • Polyester material with antibacterial and biocompatible surface and preparing method and application thereof
  • Polyester material with antibacterial and biocompatible surface and preparing method and application thereof

Examples

Experimental program
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Embodiment 1

[0039] The preparation of embodiment 1 phosphoric acid dicholine chitosan hydrochloride

[0040] Take 200mg of 6-O-triphenyl methyl etherified chitosan (CsTr) modified by chitosan (x / n=0) and dissolve it in 15mL of anhydrous dimethylacetamide, and add 0.42mL of Tris Ethylamine and 0.19mL of carbon tetrachloride; slowly add 0.46g of disubstituted choline phosphonate, wherein the molar ratio of the amino group in CsTr to phosphonate is 1:3, stir and react at 0°C for 6 hours; spin to dry the solvent , add formic acid, stir at room temperature for 1 hour; spin dry formic acid, dialyze with physiological saline and deionized water for 3 days, and freeze-dry to obtain phosphoric acid dicholine chitosan hydrochloride. Wherein the degree of substitution of the phosphoric acid dicholine group is 30%.

Embodiment 2

[0041] The preparation of embodiment 2 phosphoric acid dicholine chitosan hydrochloride

[0042] Get 500mg of 6-O-triphenyl methyl etherified chitosan (CsTr) modified by chitosan (x / n=0.2) and dissolve it in 40mL of anhydrous dimethylacetamide, add 1.05mL of Tris Ethylamine and 0.49mL of carbon tetrachloride; slowly add 2.3g of disubstituted choline phosphonate, wherein the molar ratio of the amino group in CsTr to phosphonate is 1:6, stir and react at 25°C for 12 hours; spin to dry the solvent , add formic acid, stir at room temperature for 3 hours; spin dry formic acid, dialyze with normal saline and deionized water for 3 days, and freeze-dry to obtain phosphoric acid dicholine chitosan hydrochloride. Wherein the degree of substitution of the phosphoric acid dicholine group is 50%.

Embodiment 3

[0043] The preparation of embodiment 3 phosphoric acid dicholine chitosan hydrochloride

[0044] Get 300mg of 6-O-triphenyl methyl etherified chitosan (CsTr) modified by chitosan (x / n=0.1) and dissolve it in 20mL of anhydrous dimethylacetamide, add 0.63mL of Tris Ethylamine and 0.29mL of carbon tetrachloride; slowly add 1.84g of disubstituted choline phosphonate, wherein the molar ratio of the amino group in CsTr to phosphonate is 1:8, stir and react at 40°C for 24 hours; spin to dry the solvent , add formic acid, stir at room temperature for 6 hours; spin dry formic acid, dialyze with normal saline and deionized water for 3 days, and freeze-dry to obtain phosphoric acid dicholine chitosan hydrochloride. Wherein the degree of substitution of the phosphoric acid dicholine group is 75%.

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Abstract

The invention discloses a polyester material with an antibacterial and biocompatible surface and a preparing method and application thereof. The method comprises the steps that amination of the surface of a polyester material is achieved by means of aminolysis or the plasma technique, so that a surface-aminated polyester material is obtained; the obtained surface-aminated polyester material is made to react with dialdehyde to achieve formylation of the surface of the polyester material, so that a surface-formylated polyester material is obtained; the obtained surface-formylated polyester material is made to react with citicoline chitosan salt to achieve citicoline chitosan salt immobilization of the surface of the polyester material, and washing is conducted to obtain the polyester material with the antibacterial and biocompatible surface. The adopted citicoline chitosan salt has high cytocompatibility, blood compatibility and broad-spectrum antibacterial property in the physiological environment and can be fixed to the surface of the polyester material under a mild condition, operation is easy, the polyester material with the antibacterial and biocompatible surface can be obtained, and the polyester material is suitable for implantable and interventional medical devices.

Description

technical field [0001] The invention belongs to the technical field of surface modification of polymer materials, and in particular relates to a polyester material with antibacterial properties and biocompatibility on the surface, a preparation method and application thereof. Background technique [0002] Polyester materials such as polylactic acid (PLA), polycaprolactone (PCL), and polyethylene terephthalate (PET) are widely used in medical devices such as implants, interventional catheters, and surgical instruments. At present, the adhesion of bacteria and other microorganisms and the subsequent formation of biofilms are one of the main causes of implant infection and medical device failure, which seriously threaten human health and life safety. The antibacterial technology currently used is usually to introduce antibacterial agents into the body of polyester materials, or to chemically couple or physically coat antibacterial agents on its surface to solve the complication...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08L67/02C08L67/04
Inventor 曾戎曹兆羽屠美赵剑豪
Owner JINAN UNIVERSITY
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