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Novel three-dimensional gel dosimetric material and preparation method thereof

A three-dimensional gel, three-dimensional dose technology, applied in the field of medical polymer materials, can solve the problems of decreased precision and accuracy of dose detection, loss of spatial distribution information of dose, harsh preparation and storage conditions, etc. Easy to store, short preparation cycle results

Active Publication Date: 2016-03-30
美中嘉和医学技术发展集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Existing gel dosimeters such as Fricke gel dosimeter, Fe 2+ easily oxidized to Fe by oxygen 3+ , the preparation and storage conditions are harsh, and it is not suitable for long-term storage. The dosage information carrier Fe 3+ It is easy to diffuse, the gradient information will be lost in a short time, the time and temperature stability is poor, it is not suitable for long-term storage, the cost of use is too high, and it is only for one-time use; the polymer gel dosimeter relies on the scattering effect for detection, and at the same time the scattering The signal will also interfere with the adjacent units of the detector array, reducing the precision and accuracy of dose detection; some gels, such as PAGAT gel, are easily deformed when the temperature is high, and the spatial distribution information of the dose will also be lost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Step (1), add 5mL of isopropanol and 65mL of deionized water (volume ratio: 1:13) into the irradiation tube, mix well to obtain "1#" solution;

[0030] Step (2), add 30mL of acrylic acid to the "1#" solution, and stir evenly to obtain the "2#" solution;

[0031] Step (3), add 0.0001mol cadmium chloride and 0.0002mol sodium thiosulfate to the "2#" solution, and stir evenly to obtain the "3#" solution;

[0032] Step (4), inject nitrogen into the "3#" solution for 20 minutes to remove the oxygen in the system, seal the irradiation tube, and then irradiate 20kGy through the cobalt source to obtain a new three-dimensional dosage gel material sample;

[0033] Step (5), cleaning the sample of the new three-dimensional dosage gel material, and finally obtaining a pure new three-dimensional dosage gel material.

Embodiment 2

[0035] Step (1), add 5mL of isopropanol and 65mL of deionized water (volume ratio: 1:13) into the irradiation tube, mix well to obtain "1#" solution;

[0036] Step (2), add 30mL of acrylic acid to the "1#" solution, and stir evenly to obtain the "2#" solution;

[0037] Step (3), add 0.0001mol cadmium chloride and 0.0002mol sodium thiosulfate to the "2#" solution, and stir evenly to obtain the "3#" solution;

[0038] Step (4), inject nitrogen into the "3#" solution for 20 minutes to remove the oxygen in the system, seal the irradiation tube, and then irradiate 30kGy through the cobalt source to obtain a new three-dimensional dosage gel material sample;

[0039] Step (5), cleaning the sample of the new three-dimensional dosage gel material, and finally obtaining a pure new three-dimensional dosage gel material.

Embodiment 3

[0041] Step (1), add 5mL of isopropanol and 65mL of deionized water (volume ratio: 1:13) into the irradiation tube, mix well to obtain "1#" solution;

[0042] Step (2), add 30mL of acrylic acid to the "1#" solution, and stir evenly to obtain the "2#" solution;

[0043] Step (3), add 0.0001mol cadmium chloride and 0.0002mol sodium thiosulfate to the "2#" solution, and stir evenly to obtain the "3#" solution;

[0044]Step (4), injecting nitrogen into the "3#" solution for 20 minutes to remove the oxygen in the system, sealing the irradiation tube, and then irradiating 100kGy with a cobalt source to obtain a new three-dimensional dosage gel material sample;

[0045] Step (5), cleaning the sample of the new three-dimensional dosage gel material, and finally obtaining a pure new three-dimensional dosage gel material.

[0046] Embodiments 1, 2, and 3 all use acrylic acid as a gel monomer, cadmium chloride and sodium thiosulfate as raw materials for quantum dot synthesis, and add is...

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Abstract

The invention discloses a novel three-dimensional gel dosimetric material and a preparation method thereof. The novel three-dimensional gel dosimetric material realizes calculation of dosing information according to luminescent intensity of quantum dots uniformly dispersed in hydrogel and prevents ion concentration diffusion problems of a Fricke gel dosemeter. The novel three-dimensional gel dosimetric material is prepared from simple raw materials, is free of isolation from oxygen in the environment, is free of a high temperature and can be synthesized easily. In synthesis, harmful gas is not produced and environmental harm is small. The novel three-dimensional gel dosimetric material has good physical and chemical stability, is not oxidized easily, can be stored easily and is convenient for repeated use. The preparation method of the novel three-dimensional gel dosimetric material utilizes a radiation crosslinking method, can be operated simply and easily and has a short preparation period. The novel three-dimensional gel dosimetric material is pure and does not contain impurities.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials, in particular to a novel three-dimensional gel dosimeter material and a preparation method thereof. Background technique [0002] As one of the main means of tumor treatment, radiotherapy technology has been developing in the direction of precise radiotherapy in recent years. The 24th and 42nd reports of the International Commission on Radiation Units and Measurements (ICRU) elaborated on the accuracy of radiotherapy doses. The degree must be within 5% in order to achieve effective treatment, reduce the occurrence of complications, and maximize the benefits of irradiation. To achieve the above goals, radiotherapy planning needs to pass quality assurance (QA) measures before proceeding. There is no unified standard process for dose verification. Ionization chamber method, semiconductor method, electronic portal imaging device (EPID) and gel dosimeter have appeared successively....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F120/06C08F220/56C08F220/06C08F220/10C08F2/46C08K3/16
CPCC08F2/46C08F120/06C08F220/56C08K3/16C08F220/06C08F220/10
Inventor 文万信杨韬刘汉洲闫思齐
Owner 美中嘉和医学技术发展集团股份有限公司
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