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A new three-dimensional gel dosimeter material and its preparation method

A three-dimensional gel and three-dimensional dose technology, which is applied in the field of medical polymer materials, can solve the problems of decreased precision and accuracy of dose detection, loss of spatial distribution information of doses, harsh preparation and storage conditions, etc., to facilitate mass production, Ease of storage and short preparation cycle

Active Publication Date: 2018-01-23
美中嘉和医学技术发展集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Existing gel dosimeters such as Fricke gel dosimeter, Fe 2+ easily oxidized to Fe by oxygen 3+ , the preparation and storage conditions are harsh, and it is not suitable for long-term storage. The dosage information carrier Fe 3+ It is easy to diffuse, the gradient information will be lost in a short time, the time and temperature stability is poor, it is not suitable for long-term storage, the cost of use is too high, and it is only for one-time use; the polymer gel dosimeter relies on the scattering effect for detection, and at the same time the scattering The signal will also interfere with the adjacent units of the detector array, reducing the precision and accuracy of dose detection; some gels, such as PAGAT gel, are easily deformed when the temperature is high, and the spatial distribution information of the dose will also be lost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Step (1), add 5mL of isopropanol and 65mL of deionized water (volume ratio: 1:13) into the irradiation tube, mix well to obtain "1#" solution;

[0030] Step (2), add 30mL of acrylic acid to the "1#" solution, and stir evenly to obtain the "2#" solution;

[0031] Step (3), add 0.0001mol cadmium chloride and 0.0002mol sodium thiosulfate to the "2#" solution, and stir evenly to obtain the "3#" solution;

[0032] Step (4), inject nitrogen into the "3#" solution for 20 minutes to remove the oxygen in the system, seal the irradiation tube, and then irradiate 20kGy through the cobalt source to obtain a new three-dimensional dosage gel material sample;

[0033] Step (5), cleaning the sample of the new three-dimensional dosage gel material, and finally obtaining a pure new three-dimensional dosage gel material.

Embodiment 2

[0035] Step (1), add 5mL of isopropanol and 65mL of deionized water (volume ratio: 1:13) into the irradiation tube, mix well to obtain "1#" solution;

[0036] Step (2), add 30mL of acrylic acid to the "1#" solution, and stir evenly to obtain the "2#" solution;

[0037] Step (3), add 0.0001mol cadmium chloride and 0.0002mol sodium thiosulfate to the "2#" solution, and stir evenly to obtain the "3#" solution;

[0038] Step (4), inject nitrogen into the "3#" solution for 20 minutes to remove the oxygen in the system, seal the irradiation tube, and then irradiate 30kGy through the cobalt source to obtain a new three-dimensional dosage gel material sample;

[0039] Step (5), cleaning the sample of the new three-dimensional dosage gel material, and finally obtaining a pure new three-dimensional dosage gel material.

Embodiment 3

[0041] Step (1), add 5mL of isopropanol and 65mL of deionized water (volume ratio: 1:13) into the irradiation tube, mix well to obtain "1#" solution;

[0042] Step (2), add 30mL of acrylic acid to the "1#" solution, and stir evenly to obtain the "2#" solution;

[0043] Step (3), add 0.0001mol cadmium chloride and 0.0002mol sodium thiosulfate to the "2#" solution, and stir evenly to obtain the "3#" solution;

[0044]Step (4), injecting nitrogen into the "3#" solution for 20 minutes to remove the oxygen in the system, sealing the irradiation tube, and then irradiating 100kGy with a cobalt source to obtain a new three-dimensional dosage gel material sample;

[0045] Step (5), cleaning the sample of the new three-dimensional dosage gel material, and finally obtaining a pure new three-dimensional dosage gel material.

[0046] Embodiments 1, 2, and 3 all use acrylic acid as a gel monomer, cadmium chloride and sodium thiosulfate as raw materials for quantum dot synthesis, and add is...

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Abstract

Disclosed are a new type of three-dimensional gel dosimetry material, and a method for preparation thereof; the three-dimensional gel dosimetry material is used to calculate dosage information according to the intensity of light emitted by quantum dots uniformly distributed in the hydrogel, preventing the problem of Fricke gel dosimetry ion-concentration diffusion; the raw materials required for synthesis of the new type of three-dimensional gel dosimetry material are simple, it is unnecessary to isolate oxygen from the environment, high temperature is not required, synthesis is easy, and high-volume production is convenient; during the process of synthesis, harmful gases are not generated, and harm to the environment is small; the physical and chemical stability of the obtained material is good, and the material is not prone to oxidation, is easy to store, and is convenient to use multiple times. The method for preparing the new type of three-dimensional gel dosimetry material uses radiation crosslinking, implementation is simple and easy, the period of preparation is short, and the new type of three-dimensional dosimetry material prepared using the method is pure and does not contain impurities.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials, in particular to a novel three-dimensional gel dosimeter material and a preparation method thereof. Background technique [0002] As one of the main means of tumor treatment, radiotherapy technology has been developing in the direction of precise radiotherapy in recent years. The 24th and 42nd reports of the International Commission on Radiation Units and Measurements (ICRU) elaborated on the accuracy of radiotherapy doses. The degree must be within 5% in order to achieve effective treatment, reduce the occurrence of complications, and maximize the benefits of irradiation. To achieve the above goals, radiotherapy planning needs to pass quality assurance (QA) measures before proceeding. There is no unified standard process for dose verification. Ionization chamber method, semiconductor method, electronic portal imaging device (EPID) and gel dosimeter have appeared successively....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F120/06C08F220/56C08F220/06C08F220/10C08F2/46C08K3/16
CPCC08F2/46C08F120/06C08F220/56C08K3/16C08F220/06C08F220/10
Inventor 文万信杨韬刘汉洲闫思齐
Owner 美中嘉和医学技术发展集团股份有限公司