Preparing method of magnetic-electro dual function nanofiber membrane

A nanofiber membrane, dual-functional technology, applied in fiber processing, spinning solution preparation, electrospinning, etc., can solve the problems of not being able to respond to electrical and magnetic stimuli at the same time, achieve good magnetic properties, good electrical conductivity, and synthetic methods simple effect

Inactive Publication Date: 2016-05-04
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to overcome the shortcomings of existing materials that cannot respond to electrical

Method used

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  • Preparing method of magnetic-electro dual function nanofiber membrane
  • Preparing method of magnetic-electro dual function nanofiber membrane

Examples

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Embodiment 1

[0027] Example 1: PEDOT / Fe 3 o 4 Preparation of / PLGA magnetic-electric bifunctional nanofibrous membrane:

[0028] Will Fe 3 o 4 Magnetic nanoparticles were mixed into 36% wvPLGA spinning solution (Fe 3 o 4 :PLGA=1:10w / w), Fe was obtained by electrospinning technology 3 o 4 / PLGA magnetic electrospinning nanofiber membrane, add conductive polymer monomer 80mM3,4 ethylenedioxythiophene EDOT in the ethanol / deionized water solvent of volume ratio 1:1; Prepare sodium p-toluenesulfonate (5mM ) and FeCl 3 ·6H 2 O (200mM) mixed solution, sonicated until completely dissolved; 36% wvFe 3 o 4 / PLGA fiber membrane is peeled off from the aluminum foil, placed in an open Petri dish after vacuum drying, EDOT monomer solution is added, and sodium p-toluenesulfonate and FeCl are added after 1 minute 3 place the culture dish on a shaker and shake slightly for 8 hours to carry out the polymerization reaction; take out the fully polymerized fiber membrane, wash it three times with me...

Embodiment 2

[0029] Embodiment 2: Polypyrrole (PPy) / Fe 3 o 4 / Preparation of polycaprolactone (PCL) magnetic-electric bifunctional nanofibrous membrane: Fe 3 o 4 Magnetic nanoparticles were mixed into 24% wvPCL spinning solution (Fe 3 o 4 :PCL=1:5w / w), obtain Fe by electrospinning technology 3 o 4 / PCL magnetic electrospinning nanofiber membrane, add conductive polymer monomer 200mM pyrrole in deionized water solvent; prepare camphorsulfonic acid (10mM) and FeCl 3 ·6H 2 O (400mM) mixed solution, sonicated until completely dissolved; 24% wvFe 3 o 4 / PCL fiber membrane is peeled off from the aluminum foil, and placed in an open petri dish after vacuum drying, adding pyrrole monomer solution, and adding p-camphorsulfonic acid and FeCl after 1 minute 3 Place the culture dish on a shaker and shake slightly for 12 hours to carry out the polymerization reaction; take out the fully polymerized fiber membrane, wash it with deionized water ultrasonically three times to remove the residual o...

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PUM

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Abstract

The invention provides a preparing method of a magnetic-electro dual function nanofiber membrane, which can be used for a scaffold material for tissue engineering. Fe3O4 magnetic nanoparticles are dispersed in a polymer spinning solution, magnetic nanopolymer fiber can be obtained by an electrospinning technique, and conductive high polymer monomers are polymerized at the surface of magnetic electrospinning nanofiber by an in-situ chemical oxidation method to obtain the magnetic-electro dual function nanofiber membrane. The nanofiber membrane prepared by the method has well conductivity and magnetism, and has a promotion action for cell proliferation.

Description

technical field [0001] The invention relates to the technical field of electrospinning and biomedical materials, more precisely, relates to a preparation method of a magnetic-electric dual-functional nanofiber membrane. Background technique [0002] In recent years, tissue engineering and regenerative medicine have received extensive attention. How to promote the rapid and healthy growth of cells in vitro / in vivo has become a major challenge for clinical application. Tissue cells in living organisms are in a very complex environment, not only affected by biological, chemical and other factors, microcurrent and magnetic field in the body also have a great impact on the growth and function of cells. Electrospun fiber scaffolds are not only similar to extracellular matrix in shape, structure and size, but also have good mechanical properties, which meet the material requirements of tissue engineering scaffolds, while electrospun nanofiber materials with conductive or magnetic p...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/02D01D1/02D01D5/00D04H1/728D01F6/92D01F1/10D06M15/61C08G61/12D06M101/32
CPCA61L27/025A61L27/18C08G61/12C08G2261/11C08G2261/18C08G2261/3221C08G2261/3223D01D1/02D01D5/003D01F1/10D01F6/92D04H1/728D06M15/61D06M2101/32C08L65/00C08L67/04
Inventor 李萍张书培李昆牛旭锋樊瑜波
Owner BEIHANG UNIV
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