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Magnesium-containing multiphase porous bioceramic

A bioceramic and porous stent technology, applied in the field of medical materials, can solve the problems of not having good three-dimensional interconnected mesh structure, degradability and biological activity, and achieve the effect of good mechanical strength

Active Publication Date: 2016-05-18
李亚屏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the problem that the existing bone graft substitute materials cannot have a good three-dimensional interconnected mesh structure, degradability and biological activity, etc., and provide a magnesium-containing composite phase with a good three-dimensional interconnected mesh structure and degradability porous bioceramics

Method used

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Examples

Experimental program
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Effect test

preparation example 1

[0036] (1) cutting bovine femoral condyle cancellous bone into bone strips with a thickness of 0.5-1.0 cm to obtain raw bone;

[0037] (2) Put the raw bone in distilled water and cook it in a pressure cooker (the water temperature can reach up to 116°C±1°C) for 35 minutes, then wash it with 60°C water, repeat this step 6 times;

[0038] (3) Dry the raw bone treated in step (2) in a constant temperature oven at 90°C for 48 hours, then place it in a calcination furnace, and calcinate it at 1100°C (heating rate 10°C / min) for 10 hours, and then cool it with the furnace to obtain beef bone. Calcined cancellous bone mineral porous scaffold.

[0039] The results of X-ray powder diffraction analysis of bovine calcined cancellous bone ore were hydroxyapatite.

preparation example 2

[0041] (1) cutting bovine cancellous bone (bovine femoral condyle cancellous bone) into bone strips and bone blocks with a thickness of 0.5-1 cm to obtain raw bone;

[0042] (2) The raw bone is placed in distilled water and boiled in a pressure cooker for 50 minutes, then washed with pH water, and this step is repeated 5 times;

[0043] (3) Dry the raw bone treated in step (2) in a constant temperature oven at 100°C for 24 hours, then place it in a calciner, and calcinate it at 1000°C (heating rate 10°C / min) for 12 hours, and then cool it with the furnace to obtain beef bone. Calcined cancellous bone mineral porous scaffold.

[0044] The results of X-ray powder diffraction analysis of bovine calcined cancellous bone ore were hydroxyapatite.

preparation example 3

[0046] (1) cutting bovine femoral condyle cancellous bone into bone blocks with a thickness of 1-2 cm to obtain raw bone;

[0047] (2) Put the raw bone in distilled water and cook it in a pressure cooker for 60 minutes, then wash it with water at 60°C, and repeat this step 5 times;

[0048] (3) Dry the raw bone treated in step (2) in a constant temperature oven at 120°C for 12 hours, then place it in a calciner, calcinate it at 1200°C (heating rate 10°C / min) for 8 hours, and cool it with the furnace to obtain a cow Calcined cancellous bone mineral porous scaffold.

[0049] The results of X-ray powder diffraction analysis of bovine calcined cancellous bone ore were hydroxyapatite.

[0050] Embodiment overall scheme 1:

[0051] A: Immerse the bovine calcined cancellous bone ore porous scaffold in the magnesium source-phosphorus source composite solution (the solid-liquid ratio of the bovine calcined cancellous bone ore porous scaffold to the magnesium source-phosphorus source ...

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Abstract

The invention discloses magnesium-containing multiphase porous bioceramic. The magnesium-containing multiphase porous bioceramic is obtained through calcination after a calcined bovine cancellous bone mineral porous scaffold dipped in a magnesium source-phosphorus source composite solution is dried. The material has excellent three-dimensional interconnected mesh structure, better mechanical strength and biodegradability and can release calcium, phosphorus, magnesium and other bone-formation beneficial ions; in the early stage of in-vivo transplantation of animals, repairing cells have excellent adhesion, proliferation, differentiation and bone matrix secretion in the three-dimensional porous structure of the transplantation material, bone repairing is good, and inflammatory reactions and immunological rejections are avoided in the observation period.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a composite porous bioceramic containing magnesium. Background technique [0002] Bone grafting is required for bone defects caused by accidents, bone disease, war, or orthopedic surgery. There are more than 1 million cases of bone transplantation in the United States every year; according to the population ratio, it is estimated that more than 4 million cases of bone transplantation are required in China every year, and more than 20 million cases of bone transplantation are required in the world every year. Autologous bone transplantation is the gold standard for the treatment of bone defects, but it adds new trauma to the patient, there are certain complications in the bone harvesting area, and the source of autologous bone is limited. Some cases are not suitable for autologous bone transplantation. The research and development of bone substitute materials is one of the key po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/56A61L27/12A61L27/04A61L27/50
CPCA61L27/025A61L27/047A61L27/12A61L27/3608A61L27/365A61L27/3691A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/112A61L2300/412A61L2300/604A61L2430/02C04B35/447C04B38/08C04B2201/50C04B2235/3206C04B2235/3208C04B2235/3213C04B2235/3284C04B2235/448C04B2235/616C04B38/0074C04B38/0051A61L27/46A61L2430/40A61L27/3687A61L27/40
Inventor 李桑毛海蛟汤亭亭傅俊熊汉锋聂磊李亚屏郑建民张国锋
Owner 李亚屏
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