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Medicine composition containing magnesium isoglycyrrhizinate and preparation method

A technology of magnesium isoglycyrrhizinate and magnesium glycyrrhizinate tablet cores, applied in the field of medicine, can solve the problems of poor oral bioavailability, unstable magnesium isoglycyrrhizinate, etc., and achieve the effects of convenient medication, improved dissolution, and improved in vivo bioavailability

Active Publication Date: 2016-06-01
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, magnesium isoglycyrrhizinate is unstable in gastric acid, easily degraded, and has poor oral bioavailability, and the marketed product is an injection

Method used

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  • Medicine composition containing magnesium isoglycyrrhizinate and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Magnesium Isoglycyrrhizinate Enteric-Coated Tablets (10000 Tablets) Prescription and Preparation Method

[0037] Tablet core prescription

[0038] The name and amount of raw and auxiliary materials (kg)

[0039] Magnesium Isoglycyrrhizinate 3.0

[0040] Microcrystalline Cellulose 1.5

[0041] Mannitol 1.5

[0042] Povidone K300.24

[0043] Crospovidone 0.18

[0044] Magnesium Stearate 0.10

[0045] Enteric coating prescription

[0046] The name and amount of raw and auxiliary materials (kg)

[0047] Acrylic resin Ⅱ 0.3

[0048] Triethyl citrate 0.5

[0049] Talc powder 0.3

[0050] 1. Preparation process of magnesium isoglycyrrhizinate tablet core

[0051] 1) Grind magnesium isoglycyrrhizinate, microcrystalline cellulose, povidone K30, crospovidone, and magnesium stearate through a 100-mesh sieve respectively, and weigh the prescribed amount of magnesium isoglycyrrhizinate, microcrystalline cellulose, mannitol, and povidone K30, crospovidone, and m...

Embodiment 2

[0056] Example 2 Magnesium Isoglycyrrhizinate Enteric-Coated Tablets (10000 Tablets) Prescription and Preparation Method

[0057] Tablet core prescription

[0058] The name and amount of raw and auxiliary materials (kg)

[0059] Magnesium Isoglycyrrhizinate 3.0

[0060] Microcrystalline Cellulose 1.5

[0061] Mannitol 1.5

[0062] Povidone K300.24

[0063] Crospovidone 0.18

[0064] Magnesium Stearate 0.10

[0065] Enteric coating prescription

[0066] The name and amount of raw and auxiliary materials (kg)

[0067] Acrylic resin Ⅱ 0.3

[0068] Triethyl citrate 0.5

[0069] Talc powder 0.3

[0070] Dissolution layer prescription

[0071] The name and amount of raw and auxiliary materials (kg)

[0072] Hydroxypropyl methylcellulose 0.075

[0073] Talc powder 0.1

[0074] 1. Preparation process of magnesium isoglycyrrhizinate tablet core

[0075] 1) Grind magnesium isoglycyrrhizinate, microcrystalline cellulose, povidone K30, crospovidone, and magnesium stearate t...

Embodiment 3

[0083] Example 3 Magnesium Isoglycyrrhizinate Enteric-Coated Tablets (10000 Tablets) Prescription and Preparation Method

[0084] Tablet core prescription

[0085] The name and amount of raw and auxiliary materials (kg)

[0086] Magnesium Isoglycyrrhizinate 3.0

[0087] Microcrystalline Cellulose 1.5

[0088] Mannitol 1.5

[0089] Povidone K300.24

[0090] Crospovidone 0.18

[0091] Magnesium Stearate 0.10

[0092] Enteric coating prescription

[0093] The name and amount of raw and auxiliary materials (kg)

[0094] Acrylic resin Ⅱ 0.3

[0095] Triethyl citrate 0.5

[0096] Talc powder 0.3

[0097] Dissolution layer prescription

[0098] The name and amount of raw and auxiliary materials (kg)

[0099] Hydroxypropyl methylcellulose 0.075

[0100] Talc powder 0.1

[0101] 1. Preparation process of magnesium isoglycyrrhizinate tablet core

[0102] 1) Airflow crushing magnesium isoglycyrrhizinate, particle size D50≤5μm, D90≤10μm.

[0103] 2) Weigh the prescribed am...

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Abstract

The invention belongs to the field of medicine and particularly relates to an intelligent and novel medicine composition having anti-hepatitis B virus activity and a preparation method thereof.The medicine composition contains an enteric magnesium isoglycyrrhizinate sheet core and further contains other types of anti-hepatitis B virus medicine.To be specific, further improvement is made on the basis of the prior art, a dissolution layer is further added outside an enteric magnesium isoglycyrrhizinate coating layer, and unexpectedly, the magnesium isoglycyrrhizinate medicine composition high in dissolution rate and good in bioavailablity is obtained.Furthermore, the dissolution layer is sequentially wrapped by a medicine containing layer and a protection layer, so that a compound preparation is formed, the compound preparation is convenient to take, and patient compliance is greatly improved.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to an intelligent, novel pharmaceutical composition with anti-hepatitis B virus activity and a preparation method thereof. Viral drugs. Background technique [0002] Hepatitis B is an infectious disease caused by hepatitis B virus (HepatitisBvirus, HBV), mainly characterized by liver inflammatory lesions and causing multiple organ damage. About 2 billion people in the world have been infected or are currently infected with HBV, and 400 million of them are chronically infected with HBV. Drugs for clinical treatment of hepatitis B include interferon, nucleoside drugs (such as lamivudine, adefovir dipivoxil, telbivudine, entecavir, tenofovir dipivoxil, etc.), traditional Chinese medicine drugs (such as matrine, Diammonium glycyrrhizinate, magnesium isoglycyrrhizinate, etc.). Among them, magnesium isoglycyrrhizinate is a new generation of glycyrrhizic acid compounds developed in Ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K9/32A61K31/704A61P1/16A61P31/20A61K31/522A61K31/675
CPCA61K9/2054A61K9/209A61K9/2853A61K9/2886A61K9/2893A61K31/522A61K31/675A61K31/704A61K2300/00
Inventor 王善春王广基张喜全陆崧武顾红梅鲁锡峰王祥建董平徐萍
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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