A kind of cross-linked hyaluronic acid dry powder and its preparation method and application

A technology of cross-linking hyaluronic acid and hyaluronic acid, which is applied in the fields of pharmaceutical formulations, toiletry preparations, cosmetic preparations, etc., and can solve the problems of large-scale industrial production, hyaluronic acid long-chain break degradation, and impact on dialysis operations. Gel use effect and other issues, to achieve the effect suitable for large-scale production, thickening and skin feeling, and convenient for clinical use
CN105670011BActive Publication Date: 2019-01-08BLOOMAGE BIOTECHNOLOGY CORP LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BLOOMAGE BIOTECHNOLOGY CORP LTD
Publication Date
2019-01-08

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Abstract

The invention relates to the technical field of hyaluronic acid, in particular to crosslinked hyaluronic acid dry powder. Hyaluronic acid is dissolved in an inorganic salt water solution premixed with a crosslinking agent; an organic solvent is added, precipitates are separated out from the hyaluronic acid, a solid-liquid suspension system is formed, and a cross-linking reaction is performed; an organic solvent is added for washing the precipitates; vacuum drying is performed, and the crosslinked hyaluronic acid dry powder is obtained. The crosslinking reaction is performed in the solid-liquid suspension state, and the gelling property is better; crosslinked hyaluronic acid gels with different concentrations can be prepared from the obtained crosslinked hyaluronic acid dry powder, and use is facilitated. After the obtained crosslinked hyaluronic acid dry powder is dissolved in water, colorless transparent gel is formed, and the crosslinked hyaluronic acid dry powder has the effects that the viscoelasticity is excellent, the dry powder can perform the function of long-acting moisture retention after being applied to cosmetics, physical wrinkle filling is realized, active ingredients are released slowly, the cosmetics cosmetic is thickened, the skin feeling during use is improved and the like.
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Description

technical field

[0001] The invention relates to the technical field of hyaluronic acid, in particular to a dry powder of cross-linked hyaluronic acid, as well as its preparation method and application. Background technique

[0002] Hyaluronic acid is widely distributed in various parts of the human body, and the skin also contains a large amount of hyaluronic acid. As the human body ages, the content of hyaluronic acid in the skin gradually decreases. Hyaluronic acid has been widely used in cosmetics. It can improve skin nutrition metabolism, make skin soft, smooth, wrinkle-free, increase elasticity, and prevent aging. It is also a good transdermal absorption accelerator while moisturizing. However, when the amount is added in a large amount, it is easy to draw and get muddy during the application process, and the skin after application sweats or is in a relatively humid environment, and is prone to stickiness. Cross-linked or modified hyaluronic acid has different rheolog...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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