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Preparation method of porous nano fiber membrane

A technology of nanofiber membrane and dry membrane, which is applied in the direction of fiber chemical characteristics, rayon manufacturing, non-woven fabrics, etc. It can solve the problems of non-antibacterial, non-porous nanostructure, poor cell affinity, etc., and achieve cell Good affinity function, good breathability and moisture permeability, simple preparation method

Inactive Publication Date: 2016-08-31
YANCHENG SHIBANG TRADE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese Patent Publication No. CN104353127A provides an antibacterial silk protein material and its preparation method. In this invention, graphene quantum dots and silk protein aqueous solution are blended and then solidified and molded. The silk protein material has antibacterial effect, but it is made by solidification molding method The obtained material does not have a porous nanostructure, and the air and moisture permeability of the material is poor, and graphene quantum dots are used and compounded with heavy metal salts containing gold, platinum, lead, ruthenium, etc. The affinity of the material to cells is poor, which cannot be used as Requirements for Wound Covering Materials
Chinese Patent Publication No. CN1887362A discloses a cell culture scaffold and its preparation method. The invention uses electrospinning to compound silk protein and gelatin to prepare a porous nanofiber membrane. The material has good air and moisture permeability The compounding of materials such as gelatin improves the cell affinity of the material, but the material does not have antibacterial properties, so it is limited in the application of materials such as wound dressing

Method used

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  • Preparation method of porous nano fiber membrane
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  • Preparation method of porous nano fiber membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Disperse the washed 0.5 g flake graphene oxide in 9.5 g of anhydrous formic acid, and place it in an ultrasonic oscillator to vibrate for 2 hours to prepare a dispersion liquid in which graphene oxide is uniformly dispersed in anhydrous formic acid. The mass fraction of graphene oxide in the dispersion is 5%. Add 1.3 g of dried regenerated silk protein film to the above dispersion liquid, and stir for 2 h with a magnetic stirrer to obtain a uniform spinning liquid. The mass fraction of the regenerated silk protein dry film in the spinning solution is 11.5%. Adjust the working parameters of the electrospinning device: the voltage is 30kV, the flow rate of the spinning solution is 0.2mL / h, the distance between the spinneret and the collection device is 13cm, the above spinning solution is added to a 5mL glass syringe, and the electrospinning is carried out for 2h A porous nanofibrous membrane with a thickness of 0.5 mm is then obtained on the collection device.

Embodiment 2

[0041]Disperse the washed 0.4 g flake graphene oxide in 9.5 g of anhydrous formic acid, place it in an ultrasonic oscillator and vibrate for 2 hours, and obtain a dispersion liquid in which graphene oxide is uniformly dispersed in anhydrous formic acid. The mass fraction of graphene oxide in the dispersion is 4%. Add 1.5g regenerated silk protein dry film in above-mentioned dispersion liquid, stir 2h by magnetic stirrer, obtain uniform spinning liquid. The mass fraction of the regenerated silk protein dry film in the spinning solution is 13%. Adjust the working parameters of the electrospinning device: the voltage is 20kV, the flow rate of the spinning solution is 0.3mL / h, the distance between the spinneret and the collecting device is 15cm, the above spinning solution is added to a 5mL glass syringe, and the electrospinning process is carried out for 2h A porous nanofibrous membrane with a thickness of 0.4 mm is then obtained on the collection device.

Embodiment 3

[0043] Disperse the washed 0.3 g flake graphene oxide in 9.5 g of anhydrous formic acid, and place it in an ultrasonic oscillator to vibrate for 2 hours to prepare a dispersion liquid in which graphene oxide is uniformly dispersed in anhydrous formic acid. The mass fraction of graphene oxide in the dispersion is 3%. Add 1.2 g of dried regenerated silk protein film to the above dispersion liquid, and stir for 2 h with a magnetic stirrer to obtain a uniform spinning liquid. The mass fraction of the regenerated silk protein dry film in the spinning solution is 12%. Adjust the working parameters of the electrospinning device: the voltage is 15kV, the flow rate of the spinning solution is 0.5mL / h, the distance between the spinneret and the collecting device is 18cm, the above spinning solution is added to a 5mL glass syringe, and the electrospinning is carried out for 2h A porous nanofibrous membrane with a thickness of 0.6 mm is then obtained on the collecting device.

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Abstract

The invention provides a preparation method of a porous nano fiber membrane. The preparation method comprises the following steps: preparing flake oxide grapheme and a regenerated fibroin dry membrane; dispersing the flake oxide grapheme into an anhydrous formic acid solution, to prepare dispersion liquid; adding the regenerated fibroin dry membrane into the dispersion liquid, to prepare a mixed spinning solution; preparing the porous nano fiber membrane from the mixed spinning solution. The porous fiber membrane prepared by the preparation method disclosed by the invention is high in breathability and moisture-penetrability, good in cell affinity function and better in antibacterial effect; furthermore, the preparation method is simple, and suitable for batch production.

Description

technical field [0001] The invention relates to a method for preparing a membrane, more particularly to a method for preparing a porous nanofiber membrane with both antibacterial and cell-affinity enhancement. Background technique [0002] The main components of silk are sericin and fibroin. As a natural polymer material, silk fibroin is abundant. After a lot of research by domestic and foreign scholars, it has been found that the regenerated silk fibroin obtained from silk degumming, dissolution and purification has good biodegradability and biocompatibility, and is non-toxic and non-irritating, and is easy to process into various forms. At present, scholars at home and abroad have been able to prepare silk protein materials into film-like materials proficiently, and use these materials in the field of biomedical materials such as wound coating. However, silk protein also has its inherent defects. For example, silk protein material is not antibacterial, and lacks recogniti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D04H1/30D01F1/10
CPCD01F1/103D04H1/30D04H1/728
Inventor 王曙东樊理山瞿才新
Owner YANCHENG SHIBANG TRADE
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